| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | norethindrone 20.56 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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118 genes differentially expressed following the CRCGN009_HEPG2_24H:E01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 6.70415 |
| KIFBP | kinesin family binding protein | 5.79291 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 5.2003 |
| C2CD2 | C2 calcium-dependent domain containing 2 | 4.86206 |
| AMDHD2 | amidohydrolase domain containing 2 | 4.49178 |
| CNPY3 | canopy FGF signaling regulator 3 | 4.38181 |
| RPL39L | ribosomal protein L39-like | 4.26612 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 4.21525 |
| TXNRD1 | thioredoxin reductase 1 | 4.09733 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 4.05592 |
| UGDH | UDP-glucose 6-dehydrogenase | 3.72147 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 3.67821 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 3.62142 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 3.58489 |
| MVP | major vault protein | 3.50762 |
| TBXA2R | thromboxane A2 receptor | 3.43651 |
| RAP1GAP | RAP1 GTPase activating protein | 3.38478 |
| SLC75A1 | solute carrier family 75 member 1 | 3.16571 |
| ABHD4 | abhydrolase domain containing 4 | 3.12242 |
| SQSTM1 | sequestosome 1 | 2.93128 |
| STIMATE | STIM activating enhancer | 2.91992 |
| LCN2 | lipocalin 2 | 2.89323 |
| INPP1 | inositol polyphosphate-1-phosphatase | 2.85458 |
| CISD1 | CDGSH iron sulfur domain 1 | 2.84754 |
| CBR3 | carbonyl reductase 3 | 2.79042 |
| PMM2 | phosphomannomutase 2 | 2.73934 |
| TPD52L2 | tumor protein D52-like 2 | 2.65519 |
| MICALL1 | MICAL-like 1 | 2.62612 |
| AXIN1 | axin 1 | 2.6179 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 2.60974 |
| GARRE1 | granule associated Rac and RHOG effector 1 | 2.59394 |
| NOTCH1 | notch 1 | 2.58849 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 2.56189 |
| GLRX | glutaredoxin (thioltransferase) | 2.55939 |
| VPS28 | vacuolar protein sorting 28 homolog (S. cerevisiae) | 2.51769 |
| HSPA1A | heat shock 70kDa protein 1A | 2.48438 |
| MAP7 | microtubule-associated protein 7 | 2.46914 |
| KLHL9 | kelch-like family member 9 | 2.42363 |
| CCL2 | chemokine (C-C motif) ligand 2 | 2.41174 |
| DUSP3 | dual specificity phosphatase 3 | 2.38195 |
| MCM3 | minichromosome maintenance complex component 3 | 2.35476 |
| NOSIP | nitric oxide synthase interacting protein | 2.3243 |
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 2.26753 |
| GPER1 | G protein-coupled estrogen receptor 1 | 2.2625 |
| ARAP3 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 | 2.26026 |
| PRR15L | proline rich 15-like | 2.2521 |
| LSR | lipolysis stimulated lipoprotein receptor | 2.21702 |
| RPS6KA1 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 2.21236 |
| GTPBP6 | GTP binding protein 6 (putative) | 2.1837 |
| GRB10 | growth factor receptor-bound protein 10 | 2.12989 |
| KIF5C | kinesin family member 5C | 2.10388 |
| RAB21 | RAB21, member RAS oncogene family | 2.05858 |
| ERCC3 | excision repair cross-complementation group 3 | 2.05525 |
| YIPF3 | Yip1 domain family, member 3 | 2.04013 |
| RASIP1 | Ras interacting protein 1 | 2.03896 |
| PNKP | polynucleotide kinase 3'-phosphatase | 2.03578 |
| MMP1 | matrix metallopeptidase 1 | 2.02184 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LSM6 | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -6.70442 |
| TCTN1 | tectonic family member 1 | -6.40662 |
| PCNA | proliferating cell nuclear antigen | -6.20007 |
| PLK1 | polo-like kinase 1 | -5.08009 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -4.65837 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -4.59088 |
| TSEN2 | TSEN2 tRNA splicing endonuclease subunit | -4.44934 |
| PRPF4 | pre-mRNA processing factor 4 | -4.2686 |
| ISOC1 | isochorismatase domain containing 1 | -4.07933 |
| SLC25A13 | solute carrier family 25 (aspartate/glutamate carrier), member 13 | -3.97577 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -3.97259 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -3.97073 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -3.90264 |
| CCNB2 | cyclin B2 | -3.84972 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -3.51796 |
| CDK1 | cyclin-dependent kinase 1 | -3.49326 |
| LOC124907782 | dual specificity protein phosphatase 22 | -3.47584 |
| LBR | lamin B receptor | -3.44717 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -3.38124 |
| CCNA2 | cyclin A2 | -3.37766 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -3.27211 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -3.17318 |
| AURKA | aurora kinase A | -2.98273 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -2.91638 |
| YKT6 | YKT6 v-SNARE homolog (S. cerevisiae) | -2.9116 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -2.90711 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.89915 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -2.81638 |
| AURKB | aurora kinase B | -2.79038 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -2.75862 |
| VDAC1 | voltage-dependent anion channel 1 | -2.71451 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -2.70542 |
| CDC20 | cell division cycle 20 | -2.67801 |
| MELK | maternal embryonic leucine zipper kinase | -2.66257 |
| CENPE | centromere protein E, 312kDa | -2.64976 |
| CPSF4 | cleavage and polyadenylation specific factor 4, 30kDa | -2.60211 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | -2.56447 |
| BLCAP | bladder cancer associated protein | -2.55286 |
| DBF4 | DBF4 zinc finger | -2.50564 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -2.4644 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -2.43688 |
| FBXO5 | F-box protein 5 | -2.43053 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -2.40972 |
| FBXO7 | F-box protein 7 | -2.39176 |
| TIMM8A | translocase of inner mitochondrial membrane 8 homolog A (yeast) | -2.3709 |
| BIRC5 | baculoviral IAP repeat containing 5 | -2.3546 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -2.33583 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | -2.30442 |
| DDIT4 | DNA-damage-inducible transcript 4 | -2.28326 |
| TBPL1 | TBP-like 1 | -2.26179 |
| MYCBP | MYC binding protein | -2.25097 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -2.21216 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | -2.17376 |
| NUP54 | nucleoporin 54kDa | -2.16616 |
| CEP85 | centrosomal protein 85kDa | -2.15183 |
| SDAD1 | SDA1 domain containing 1 | -2.14256 |
| ERI2 | ERI1 exoribonuclease family member 2 | -2.12185 |
| CCNB1 | cyclin B1 | -2.07694 |
| POLR1G | RNA polymerase I subunit G | -2.03676 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | -2.01898 |
| LSM4 | LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.01404 |
