CRCGN009_HEPG2_24H:E05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description norethindrone 1.29 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

88 genes differentially expressed following the CRCGN009_HEPG2_24H:E05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PEX11A peroxisomal biogenesis factor 11 alpha 7.50483
PRR15L proline rich 15-like 5.99431
AMDHD2 amidohydrolase domain containing 2 5.43615
MAMLD1 mastermind-like domain containing 1 5.17778
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.75451
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.60201
NOTCH1 notch 1 4.42841
UBQLN2 ubiquilin 2 4.26398
EVL Enah/Vasp-like 3.82767
HLA-DRA major histocompatibility complex, class II, DR alpha 3.60691
RAB11FIP1 RAB11 family interacting protein 1 (class I) 3.54056
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.36418
GPER1 G protein-coupled estrogen receptor 1 3.35905
NOSIP nitric oxide synthase interacting protein 3.29935
GSTZ1 glutathione S-transferase zeta 1 3.23732
VGLL4 vestigial-like family member 4 3.04419
TRAK2 trafficking protein, kinesin binding 2 2.87107
JADE2 jade family PHD finger 2 2.79335
CYCS cytochrome c, somatic 2.75392
FBXO17 F-box protein 17 2.73376
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.6247
RRAS2 related RAS viral (r-ras) oncogene homolog 2 2.58338
FSD1 fibronectin type III and SPRY domain containing 1 2.58189
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.57045
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 2.56222
TTC23 tetratricopeptide repeat domain 23 2.53214
CADM4 cell adhesion molecule 4 2.47725
SFTPB surfactant protein B 2.46082
CD40 CD40 molecule, TNF receptor superfamily member 5 2.45664
SIRT3 sirtuin 3 2.42577
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.41812
RXYLT1 ribitol xylosyltransferase 1 2.39635
LOC128966622 putative protein N-methyltransferase FAM86B2 2.38814
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor 2.37664
SCN3A sodium channel, voltage gated, type III alpha subunit 2.37588
TOLLIP toll interacting protein 2.36658
BEAN1 brain expressed, associated with NEDD4, 1 2.31149
GATA2 GATA binding protein 2 2.302
RWDD2A RWD domain containing 2A 2.27096
WDR91 WD repeat domain 91 2.23085
GPR17 G protein-coupled receptor 17 2.22735
SEMG1 semenogelin I 2.21808
MIA melanoma inhibitory activity 2.19203
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) 2.18495
SEMG2 semenogelin II 2.1836
APOA1 apolipoprotein A-I 2.16442
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 2.14896
CMA1 chymase 1, mast cell 2.13992
BPHL biphenyl hydrolase-like (serine hydrolase) 2.13555
HCFC2 host cell factor C2 2.12992
MMP1 matrix metallopeptidase 1 2.12497
MYOT myotilin 2.12262
MYF6 myogenic factor 6 (herculin) 2.11129
CRYGC crystallin, gamma C 2.10704
FTCD formimidoyltransferase cyclodeaminase 2.07268
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 2.06841
LINS1 lines homolog 1 2.05607
ARMCX6 armadillo repeat containing, X-linked 6 2.05424
TNIP1 TNFAIP3 interacting protein 1 2.04939
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.01539
NMUR1 neuromedin U receptor 1 2.01513

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -9.5547
TRIB3 tribbles pseudokinase 3 -5.15822
ISOC1 isochorismatase domain containing 1 -4.94509
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.91519
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.73474
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.5986
GOLT1B golgi transport 1B -4.59617
TP53BP2 tumor protein p53 binding protein 2 -4.56499
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.56417
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.28147
MAPK13 mitogen-activated protein kinase 13 -3.83615
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.57615
CTNND1 catenin (cadherin-associated protein), delta 1 -2.91815
NRIP1 nuclear receptor interacting protein 1 -2.89973
ZMIZ1 zinc finger, MIZ-type containing 1 -2.69792
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.64436
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.55998
SNX11 sorting nexin 11 -2.39087
ERMP1 endoplasmic reticulum metallopeptidase 1 -2.34612
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.31684
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae) -2.18751
CST7 cystatin F (leukocystatin) -2.13742
ACYP1 acylphosphatase 1, erythrocyte (common) type -2.1236
PCDH17 protocadherin 17 -2.12178
UPK2 uroplakin 2 -2.08805
FUBP3 far upstream element (FUSE) binding protein 3 -2.04464
IFNGR1 interferon gamma receptor 1 -2.0161