CRCGN009_HEPG2_24H:E07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o,o-diethyl o-(4-nitrophenyl) thiophosphate 21.22 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

60 genes differentially expressed following the CRCGN009_HEPG2_24H:E07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 6.34607
PRR15L proline rich 15-like 5.67896
RAB11FIP1 RAB11 family interacting protein 1 (class I) 4.49396
JADE2 jade family PHD finger 2 4.37357
MAP7 microtubule-associated protein 7 4.17871
CDC45 cell division cycle 45 4.14296
BZW2 basic leucine zipper and W2 domains 2 4.02753
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.01562
FCHO1 FCH domain only 1 3.75471
CCDC92 coiled-coil domain containing 92 3.58536
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.47715
CRTAP cartilage associated protein 3.35833
PHKA1 phosphorylase kinase, alpha 1 (muscle) 3.34577
ADGRE5 adhesion G protein-coupled receptor E5 3.26962
STK10 serine/threonine kinase 10 3.2642
CBR3 carbonyl reductase 3 3.25013
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.16865
STXBP1 syntaxin binding protein 1 3.12193
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.96205
RXYLT1 ribitol xylosyltransferase 1 2.77389
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.63811
VAT1 vesicle amine transport 1 2.61613
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.59006
CXCL2 chemokine (C-X-C motif) ligand 2 2.54737
INSIG1 insulin induced gene 1 2.43941
OXCT1 3-oxoacid CoA transferase 1 2.34406
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.32806
E2F2 E2F transcription factor 2 2.23782
STAP2 signal transducing adaptor family member 2 2.21395
TRAM2 translocation associated membrane protein 2 2.19095
DIPK1A divergent protein kinase domain 1A 2.17231
TPD52L2 tumor protein D52-like 2 2.15687
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.12811
RAB31 RAB31, member RAS oncogene family 2.12086
SNAP25 synaptosomal-associated protein, 25kDa 2.11294
UBQLN2 ubiquilin 2 2.09435
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.08887
CEMIP2 cell migration inducing hyaluronidase 2 2.07357
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.06482
MTA2 metastasis associated 1 family, member 2 2.04034
RPL39L ribosomal protein L39-like 2.02131

decreased expression

Symbol Name Standardized Value
TLR4 toll-like receptor 4 -6.5402
OXA1L oxidase (cytochrome c) assembly 1-like -5.6673
LDHD lactate dehydrogenase D -5.56902
SLC35F2 solute carrier family 35, member F2 -5.36008
NGRN neugrin, neurite outgrowth associated -4.74257
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.54809
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.42111
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.73273
CHIC2 cysteine-rich hydrophobic domain 2 -2.62491
CCNB2 cyclin B2 -2.61953
RNF167 ring finger protein 167 -2.56968
EIF5 eukaryotic translation initiation factor 5 -2.24348
RAI14 retinoic acid induced 14 -2.20897
ARID5B AT rich interactive domain 5B (MRF1-like) -2.1929
TXNDC9 thioredoxin domain containing 9 -2.164
ZNF274 zinc finger protein 274 -2.1499
TCEAL4 transcription elongation factor A (SII)-like 4 -2.07712
MCTP1 multiple C2 domains, transmembrane 1 -2.04182
PPOX protoporphyrinogen oxidase -2.04101