CRCGN009_HEPG2_24H:E08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o,o-diethyl o-(4-nitrophenyl) thiophosphate 10.61 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

37 genes differentially expressed following the CRCGN009_HEPG2_24H:E08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 10.0
GSTZ1 glutathione S-transferase zeta 1 7.61194
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.37715
LPAR2 lysophosphatidic acid receptor 2 5.22155
E2F2 E2F transcription factor 2 4.50332
HLA-DMA major histocompatibility complex, class II, DM alpha 4.30611
UBQLN2 ubiquilin 2 4.27507
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.14936
MAP7 microtubule-associated protein 7 3.98302
STAP2 signal transducing adaptor family member 2 3.91034
EPHA3 EPH receptor A3 3.90854
CCL2 chemokine (C-C motif) ligand 2 3.77698
ABHD6 abhydrolase domain containing 6 3.7494
HDGFL3 HDGF like 3 3.47322
CHN1 chimerin 1 3.00581
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.77074
CCNF cyclin F 2.5147
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.46022
TSPAN6 tetraspanin 6 2.41393
GPER1 G protein-coupled estrogen receptor 1 2.32191
TCEA2 transcription elongation factor A (SII), 2 2.21591
PARP2 poly (ADP-ribose) polymerase 2 2.13995
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.06847
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 2.03773
CDK6 cyclin-dependent kinase 6 2.0281

decreased expression

Symbol Name Standardized Value
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -9.6635
LOC124907782 dual specificity protein phosphatase 22 -5.72896
OXA1L oxidase (cytochrome c) assembly 1-like -5.02347
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.55181
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.53761
SLC35F2 solute carrier family 35, member F2 -4.48736
PEG10 paternally expressed 10 -4.40161
GNAS GNAS complex locus -3.57812
C5 complement component 5 -2.7937
TCEAL4 transcription elongation factor A (SII)-like 4 -2.62223
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.60654
RNF167 ring finger protein 167 -2.34883