CRCGN009_HEPG2_24H:E13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description clotrimazole 20.56 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

621 genes differentially expressed following the CRCGN009_HEPG2_24H:E13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 8.97289
TIMP2 TIMP metallopeptidase inhibitor 2 8.81056
SQOR sulfide quinone oxidoreductase 8.3004
CNPY3 canopy FGF signaling regulator 3 8.11061
INPP1 inositol polyphosphate-1-phosphatase 7.87852
TRIB3 tribbles pseudokinase 3 7.6226
PPARG peroxisome proliferator-activated receptor gamma 7.46822
TXNRD1 thioredoxin reductase 1 7.16264
VAT1 vesicle amine transport 1 6.90042
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 6.8785
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 6.72327
GPER1 G protein-coupled estrogen receptor 1 6.60916
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 6.57683
FOSL1 FOS-like antigen 1 6.52413
MVP major vault protein 6.38964
BZW2 basic leucine zipper and W2 domains 2 6.08332
GFPT1 glutamine--fructose-6-phosphate transaminase 1 6.04203
NR1H2 nuclear receptor subfamily 1, group H, member 2 6.02535
SQSTM1 sequestosome 1 5.9907
ALAS1 5'-aminolevulinate synthase 1 5.95279
GRB10 growth factor receptor-bound protein 10 5.93228
CDPF1 cysteine-rich, DPF motif domain containing 1 5.91428
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 5.39963
STX1A syntaxin 1A (brain) 5.38842
EGR1 early growth response 1 5.35837
LRP10 low density lipoprotein receptor-related protein 10 5.34015
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 5.26792
KIFBP kinesin family binding protein 5.24969
IER3 immediate early response 3 5.18535
MICALL1 MICAL-like 1 5.01789
DDIT4 DNA-damage-inducible transcript 4 4.97443
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 4.78374
PNKP polynucleotide kinase 3'-phosphatase 4.77435
MYLK myosin light chain kinase 4.72574
IL4R interleukin 4 receptor 4.68687
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 4.67915
GSTZ1 glutathione S-transferase zeta 1 4.6746
NANOS3 nanos homolog 3 (Drosophila) 4.62707
IGFBP3 insulin-like growth factor binding protein 3 4.52015
ZFP36 ZFP36 ring finger protein 4.40297
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.39349
TERF2IP telomeric repeat binding factor 2, interacting protein 4.37209
KDM5A lysine (K)-specific demethylase 5A 4.34106
DIPK1A divergent protein kinase domain 1A 4.30272
SLC35F2 solute carrier family 35, member F2 4.21836
PRAF2 PRA1 domain family, member 2 4.20831
RALB v-ral simian leukemia viral oncogene homolog B 4.12089
MAPK13 mitogen-activated protein kinase 13 4.10111
ACOT9 acyl-CoA thioesterase 9 4.09789
MSRA methionine sulfoxide reductase A 4.09674
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 4.0619
FHL2 four and a half LIM domains 2 4.05528
ANO1 anoctamin 1, calcium activated chloride channel 4.04007
KLHL21 kelch-like family member 21 4.02454
ABHD4 abhydrolase domain containing 4 3.98539
PRKCQ protein kinase C, theta 3.93822
SARS1 seryl-tRNA synthetase 1 3.88836
MYC v-myc avian myelocytomatosis viral oncogene homolog 3.88641
CEMIP2 cell migration inducing hyaluronidase 2 3.80817
CAB39 calcium binding protein 39 3.78505
AARS1 alanyl-tRNA synthetase 1 3.74549
ASCC1 activating signal cointegrator 1 complex subunit 1 3.64303
CTTN cortactin 3.62465
TRIB1 tribbles pseudokinase 1 3.58543
TOMM34 translocase of outer mitochondrial membrane 34 3.55246
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.55017
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.5431
GIPC1 GIPC PDZ domain containing family, member 1 3.43233
DSG2 desmoglein 2 3.43172
TUBB6 tubulin, beta 6 class V 3.41674
MGLL monoglyceride lipase 3.40689
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.40357
SOCS2 suppressor of cytokine signaling 2 3.39906
CASC3 cancer susceptibility candidate 3 3.39115
CIAO3 cytosolic iron-sulfur assembly component 3 3.36704
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 3.35558
YARS1 tyrosyl-tRNA synthetase 1 3.32435
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 3.30863
JOSD1 Josephin domain containing 1 3.26378
TNIP1 TNFAIP3 interacting protein 1 3.18305
PPARD peroxisome proliferator-activated receptor delta 3.13772
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.10975
NPDC1 neural proliferation, differentiation and control, 1 3.10949
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 3.10766
GTPBP2 GTP binding protein 2 3.09651
CYTH2 cytohesin 2 3.0923
STN1 STN1 subunit of CST complex 3.0494
CLIP4 CAP-GLY domain containing linker protein family, member 4 3.04875
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.02597
LPGAT1 lysophosphatidylglycerol acyltransferase 1 3.01297
SHB Src homology 2 domain containing adaptor protein B 2.96871
GARS1 glycyl-tRNA synthetase 1 2.94208
FASTKD5 FAST kinase domains 5 2.93182
CARS1 cysteinyl-tRNA synthetase 1 2.92128
STAP2 signal transducing adaptor family member 2 2.89787
GRWD1 glutamate-rich WD repeat containing 1 2.89736
CHUK conserved helix-loop-helix ubiquitous kinase 2.89579
RAP1GAP RAP1 GTPase activating protein 2.88819
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 2.87417
SOX4 SRY (sex determining region Y)-box 4 2.86872
ITGB6 integrin, beta 6 2.85327
PROCR protein C receptor, endothelial 2.84641
SMAD3 SMAD family member 3 2.84627
TRIM8 tripartite motif containing 8 2.83014
GLRX glutaredoxin (thioltransferase) 2.82128
LOC128125814 uncharacterized LOC128125814 2.81236
IDE insulin-degrading enzyme 2.80307
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 2.79041
CCNA1 cyclin A1 2.78601
GSK3B glycogen synthase kinase 3 beta 2.76246
TRAK2 trafficking protein, kinesin binding 2 2.74736
ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) 2.7257
EPB41L1 erythrocyte membrane protein band 4.1-like 1 2.72493
CSNK1E casein kinase 1, epsilon 2.72082
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 2.71435
PCDHB11 protocadherin beta 11 2.71337
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 2.68935
PDGFA platelet-derived growth factor alpha polypeptide 2.6852
SH3GLB1 SH3-domain GRB2-like endophilin B1 2.66158
MEAK7 MTOR associated protein, eak-7 homolog 2.65658
AHNAK2 AHNAK nucleoprotein 2 2.64583
TGFB1I1 transforming growth factor beta 1 induced transcript 1 2.64419
YIPF3 Yip1 domain family, member 3 2.63041
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 2.61944
UNC13A unc-13 homolog A (C. elegans) 2.61545
MBNL2 muscleblind-like splicing regulator 2 2.61421
ATP9A ATPase, class II, type 9A 2.60882
BDH1 3-hydroxybutyrate dehydrogenase, type 1 2.60441
RASAL2 RAS protein activator like 2 2.58248
PTPN12 protein tyrosine phosphatase, non-receptor type 12 2.58226
MAP7 microtubule-associated protein 7 2.57668
RAB9A RAB9A, member RAS oncogene family 2.56779
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 2.55827
ATF4 activating transcription factor 4 2.55775
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 2.55094
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 2.55
SFXN3 sideroflexin 3 2.54289
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.54017
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.53888
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 2.53704
DBN1 drebrin 1 2.51714
ITGB5 integrin, beta 5 2.5152
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.48953
IL37 interleukin 37 2.47254
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma 2.46645
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 2.46546
FCHO1 FCH domain only 1 2.45805
DUSP8 dual specificity phosphatase 8 2.45455
RBKS ribokinase 2.4472
ADGRG1 adhesion G protein-coupled receptor G1 2.44672
UPP1 uridine phosphorylase 1 2.44359
ARHGAP22 Rho GTPase activating protein 22 2.43226
ITCH itchy E3 ubiquitin protein ligase 2.41864
ZDHHC7 zinc finger, DHHC-type containing 7 2.41537
STX5 syntaxin 5 2.40565
TARS1 threonyl-tRNA synthetase 1 2.40341
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 2.40313
RGS2 regulator of G-protein signaling 2 2.39773
ERCC1 excision repair cross-complementation group 1 2.394
ZFAND1 zinc finger, AN1-type domain 1 2.38818
RAB11FIP2 RAB11 family interacting protein 2 (class I) 2.38468
RAI14 retinoic acid induced 14 2.38431
PSD3 pleckstrin and Sec7 domain containing 3 2.37722
TMEM184B transmembrane protein 184B 2.37665
SNX7 sorting nexin 7 2.37566
MAN2A1 mannosidase, alpha, class 2A, member 1 2.3618
NT5E 5'-nucleotidase, ecto (CD73) 2.35502
MYH9 myosin, heavy chain 9, non-muscle 2.3541
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 2.35231
KIAA0513 KIAA0513 2.35044
LIN37 lin-37 DREAM MuvB core complex component 2.34842
MNT MAX network transcriptional repressor 2.34621
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.3449
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.33873
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 2.32309
CBR3 carbonyl reductase 3 2.31064
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 2.30831
MTCH1 mitochondrial carrier 1 2.29793
CEP170 centrosomal protein 170kDa 2.29669
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 2.29577
GOLT1A golgi transport 1A 2.28329
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 2.28192
CLTB clathrin, light chain B 2.27604
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 2.27045
DVL1 dishevelled segment polarity protein 1 2.26436
TICAM1 toll-like receptor adaptor molecule 1 2.2641
MICU1 mitochondrial calcium uptake 1 2.26241
LARP6 La ribonucleoprotein domain family, member 6 2.26241
TPD52L2 tumor protein D52-like 2 2.2577
ANO10 anoctamin 10 2.25466
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 2.2513
MCOLN3 mucolipin 3 2.2456
PLK3 polo-like kinase 3 2.24369
ITPRID2 ITPR interacting domain containing 2 2.24156
EIF6 eukaryotic translation initiation factor 6 2.23585
SPATA2L spermatogenesis associated 2-like 2.23564
FPGS folylpolyglutamate synthase 2.23237
EPRS1 glutamyl-prolyl-tRNA synthetase 1 2.22814
THBD thrombomodulin 2.22786
PRKCD protein kinase C, delta 2.22546
CDA cytidine deaminase 2.22537
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.22211
HLA-DMA major histocompatibility complex, class II, DM alpha 2.21972
ATF6 activating transcription factor 6 2.21739
PTK2 protein tyrosine kinase 2 2.20986
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 2.20351
ZC3H15 zinc finger CCCH-type containing 15 2.19721
SNX6 sorting nexin 6 2.18908
CPM carboxypeptidase M 2.18365
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 2.18203
PLPP6 phospholipid phosphatase 6 2.18049
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa 2.17241
UBR4 ubiquitin protein ligase E3 component n-recognin 4 2.16835
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.16614
PORCN porcupine homolog (Drosophila) 2.15931
ZBTB35 zinc finger and BTB domain containing 35 2.15201
EHD4 EH-domain containing 4 2.14806
BYSL bystin-like 2.14592
SERINC1 serine incorporator 1 2.14199
DUSP3 dual specificity phosphatase 3 2.13775
HOMER2 homer scaffolding protein 2 2.1357
MRPL37 mitochondrial ribosomal protein L37 2.12871
EVL Enah/Vasp-like 2.12836
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 2.12474
IER2 immediate early response 2 2.12174
TAOK3 TAO kinase 3 2.11859
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 2.11453
MAP7D1 MAP7 domain containing 1 2.10976
ZMYM2 zinc finger, MYM-type 2 2.10365
IFRD1 interferon-related developmental regulator 1 2.10311
RGL2 ral guanine nucleotide dissociation stimulator-like 2 2.10275
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 2.10251
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 2.0993
ARHGAP10 Rho GTPase activating protein 10 2.09243
GPKOW G patch domain and KOW motifs 2.09004
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 2.08514
FOXD1 forkhead box D1 2.08067
RBM42 RNA binding motif protein 42 2.0722
TPM4 tropomyosin 4 2.06977
TMC5 transmembrane channel-like 5 2.06848
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 2.06636
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.0659
KIF3B kinesin family member 3B 2.06471
MED8 mediator complex subunit 8 2.06188
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 2.05963
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 2.05904
MON1B MON1 secretory trafficking family member B 2.05439
AVPI1 arginine vasopressin-induced 1 2.05185
PDZD8 PDZ domain containing 8 2.04909
COQ10B coenzyme Q10 homolog B (S. cerevisiae) 2.04627
BIRC2 baculoviral IAP repeat containing 2 2.04385
LOC124900275 extensin-like 2.04278
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.04035
GPC1 glypican 1 2.03918
MYO6 myosin VI 2.03671
ATG3 autophagy related 3 2.03349
QTMAN queuosine-tRNA mannosyltransferase 2.03235
OSBPL9 oxysterol binding protein-like 9 2.03134
PEX2 peroxisomal biogenesis factor 2 2.02782
ZYX zyxin 2.02769
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 2.02714
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12 2.02524
GHITM growth hormone inducible transmembrane protein 2.02323
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F 2.02257
YIPF5 Yip1 domain family, member 5 2.02232
MAPK12 mitogen-activated protein kinase 12 2.02151
CTAGE8 CTAGE family, member 8 2.01852
MAP1B microtubule-associated protein 1B 2.01794
NIBAN1 niban apoptosis regulator 1 2.01505
PFDN1 prefoldin subunit 1 2.01418
LAD1 ladinin 1 2.00954
UBA1 ubiquitin-like modifier activating enzyme 1 2.00696
ZNF536 zinc finger protein 536 2.00556
AOC1 amine oxidase, copper containing 1 2.00297

decreased expression

Symbol Name Standardized Value
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -9.67946
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -9.52563
MELK maternal embryonic leucine zipper kinase -8.66041
B4GAT1 beta-1,4-glucuronyltransferase 1 -8.56804
TCTN1 tectonic family member 1 -8.2278
ISOC1 isochorismatase domain containing 1 -8.10931
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -8.05853
PCNA proliferating cell nuclear antigen -7.8184
PSRC1 proline/serine-rich coiled-coil 1 -7.58082
AURKB aurora kinase B -6.95989
CCNB1 cyclin B1 -6.95531
CCNA2 cyclin A2 -6.8795
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.81982
TOP2A topoisomerase (DNA) II alpha 170kDa -6.45979
POLR1A polymerase (RNA) I polypeptide A, 194kDa -6.36399
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -6.15246
CD320 CD320 molecule -6.12489
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -5.94574
ADI1 acireductone dioxygenase 1 -5.92438
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -5.86356
RPIA ribose 5-phosphate isomerase A -5.8438
NUP85 nucleoporin 85kDa -5.8183
STMN1 stathmin 1 -5.761
CDK1 cyclin-dependent kinase 1 -5.68454
TLR4 toll-like receptor 4 -5.67224
LBR lamin B receptor -5.53923
BIRC5 baculoviral IAP repeat containing 5 -5.4789
SOAT2 sterol O-acyltransferase 2 -5.4041
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -5.31689
CDC20 cell division cycle 20 -5.27769
PGM1 phosphoglucomutase 1 -5.03389
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -4.99267
TMEM97 transmembrane protein 97 -4.89915
PLK1 polo-like kinase 1 -4.89591
TMEM109 transmembrane protein 109 -4.78599
CCDC86 coiled-coil domain containing 86 -4.78487
PROS1 protein S (alpha) -4.73602
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -4.71456
PGAM4 phosphoglycerate mutase family member 4 -4.66946
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.55627
NGRN neugrin, neurite outgrowth associated -4.51737
KIF15 kinesin family member 15 -4.5148
HAT1 histone acetyltransferase 1 -4.49809
NFIL3 nuclear factor, interleukin 3 regulated -4.48284
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -4.47815
ASF1B anti-silencing function 1B histone chaperone -4.47051
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.43008
HADH hydroxyacyl-CoA dehydrogenase -4.36951
MLEC malectin -4.29091
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -4.26582
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -4.24813
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -4.2099
UBE2C ubiquitin-conjugating enzyme E2C -4.14351
CCNB2 cyclin B2 -4.12584
DDB2 damage-specific DNA binding protein 2, 48kDa -4.09856
ALDOC aldolase C, fructose-bisphosphate -4.08913
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.0225
FEN1 flap structure-specific endonuclease 1 -4.02124
ZW10 zw10 kinetochore protein -4.01102
NT5DC2 5'-nucleotidase domain containing 2 -4.00159
ZNF274 zinc finger protein 274 -3.9742
FANCI Fanconi anemia, complementation group I -3.75439
CHAF1A chromatin assembly factor 1, subunit A (p150) -3.74415
TEDC2 tubulin epsilon and delta complex 2 -3.72718
ZWINT ZW10 interacting kinetochore protein -3.71628
ICAM3 intercellular adhesion molecule 3 -3.68885
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -3.68635
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -3.6607
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -3.65416
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.61313
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.60493
MCM10 minichromosome maintenance complex component 10 -3.58204
AURKA aurora kinase A -3.5758
CDCA8 cell division cycle associated 8 -3.56562
MSH6 mutS homolog 6 -3.50842
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -3.49489
PXMP2 peroxisomal membrane protein 2, 22kDa -3.442
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -3.43945
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -3.42521
TFDP1 transcription factor Dp-1 -3.40242
THAP11 THAP domain containing 11 -3.39618
GTF2A2 general transcription factor IIA, 2, 12kDa -3.39414
DCK deoxycytidine kinase -3.36941
FGFR4 fibroblast growth factor receptor 4 -3.36561
TK1 thymidine kinase 1, soluble -3.35621
KLHDC2 kelch domain containing 2 -3.35078
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.34728
PARP1 poly (ADP-ribose) polymerase 1 -3.33929
KIF11 kinesin family member 11 -3.33529
GINS1 GINS complex subunit 1 (Psf1 homolog) -3.30846
KIF4A kinesin family member 4A -3.30257
HMGA2 high mobility group AT-hook 2 -3.26944
GLOD4 glyoxalase domain containing 4 -3.26778
BLCAP bladder cancer associated protein -3.25991
MRPL12 mitochondrial ribosomal protein L12 -3.22375
HMG20B high mobility group 20B -3.20191
CCNF cyclin F -3.18257
CENPE centromere protein E, 312kDa -3.15379
CENPA centromere protein A -3.12251
TBC1D10C TBC1 domain family, member 10C -3.10884
NUP107 nucleoporin 107kDa -3.10877
GLRX5 glutaredoxin 5 -3.09999
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -3.09781
HMOX1 heme oxygenase 1 -3.08033
MIS18A MIS18 kinetochore protein A -3.04815
NRIP1 nuclear receptor interacting protein 1 -3.01546
RFC5 replication factor C (activator 1) 5, 36.5kDa -3.00809
CDK2 cyclin-dependent kinase 2 -2.99463
HGH1 HGH1 homolog (S. cerevisiae) -2.97084
NASP nuclear autoantigenic sperm protein (histone-binding) -2.97028
CDC45 cell division cycle 45 -2.96715
OIP5 Opa interacting protein 5 -2.96492
FZD7 frizzled class receptor 7 -2.9649
RACGAP1 Rac GTPase activating protein 1 -2.96198
MSH2 mutS homolog 2 -2.96117
CTSL cathepsin L -2.95595
AVPR1B arginine vasopressin receptor 1B -2.94053
GINS2 GINS complex subunit 2 (Psf2 homolog) -2.93752
NCAPD2 non-SMC condensin I complex, subunit D2 -2.93681
ACAA1 acetyl-CoA acyltransferase 1 -2.93574
POLK polymerase (DNA directed) kappa -2.92558
TSPAN6 tetraspanin 6 -2.91449
MRPS7 mitochondrial ribosomal protein S7 -2.91297
MYCBP MYC binding protein -2.9106
CCS copper chaperone for superoxide dismutase -2.90934
EIF5 eukaryotic translation initiation factor 5 -2.90511
EED embryonic ectoderm development -2.90277
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.89841
RMI1 RecQ mediated genome instability 1 -2.88737
CENPM centromere protein M -2.88228
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -2.87204
NUP37 nucleoporin 37kDa -2.87043
LMNB1 lamin B1 -2.85665
FAM111A family with sequence similarity 111, member A -2.85377
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.85229
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -2.84766
ACYP1 acylphosphatase 1, erythrocyte (common) type -2.83514
KIF18B kinesin family member 18B -2.82745
H2AX H2A.X variant histone -2.82291
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.82159
KIFC1 kinesin family member C1 -2.80829
PDIA6 protein disulfide isomerase family A, member 6 -2.79202
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.78467
HNRNPM heterogeneous nuclear ribonucleoprotein M -2.78009
RBM14-RBM4 RBM14-RBM4 readthrough -2.77991
GMNN geminin, DNA replication inhibitor -2.77856
RNF123 ring finger protein 123 -2.77702
KHK ketohexokinase (fructokinase) -2.77616
CDCA3 cell division cycle associated 3 -2.76375
SNRPF small nuclear ribonucleoprotein polypeptide F -2.76269
CKS1B CDC28 protein kinase regulatory subunit 1B -2.76057
CBR4 carbonyl reductase 4 -2.75155
FDXR ferredoxin reductase -2.75094
PARPBP PARP1 binding protein -2.73095
RFC3 replication factor C (activator 1) 3, 38kDa -2.71966
TMEM106C transmembrane protein 106C -2.71397
TARDBP TAR DNA binding protein -2.71277
RPA3 replication protein A3, 14kDa -2.70442
DHFR dihydrofolate reductase -2.69924
LGMN legumain -2.69782
SPAG5 sperm associated antigen 5 -2.68765
ALG6 ALG6, alpha-1,3-glucosyltransferase -2.68514
ERCC6L excision repair cross-complementation group 6-like -2.68314
THOP1 thimet oligopeptidase 1 -2.68092
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.67721
ORC6 origin recognition complex, subunit 6 -2.67645
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12) -2.66515
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.66391
PPIH peptidylprolyl isomerase H (cyclophilin H) -2.66212
ECH1 enoyl CoA hydratase 1, peroxisomal -2.65686
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.65071
AUNIP aurora kinase A and ninein interacting protein -2.6466
RBM15B RNA binding motif protein 15B -2.64076
PRCP prolylcarboxypeptidase (angiotensinase C) -2.62912
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.62375
CDC25A cell division cycle 25A -2.61865
RRM2 ribonucleotide reductase M2 -2.6116
CDX1 caudal type homeobox 1 -2.61002
C2CD5 C2 calcium-dependent domain containing 5 -2.59543
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -2.5938
PGRMC1 progesterone receptor membrane component 1 -2.5934
TSNAXIP1 translin-associated factor X interacting protein 1 -2.59242
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -2.59006
TRMT5 tRNA methyltransferase 5 -2.58755
PPIC peptidylprolyl isomerase C (cyclophilin C) -2.58204
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -2.56409
PYCR3 pyrroline-5-carboxylate reductase 3 -2.55863
ELAC2 elaC ribonuclease Z 2 -2.55821
GLUL glutamate-ammonia ligase -2.5554
CENPX centromere protein X -2.55268
DSCC1 DNA replication and sister chromatid cohesion 1 -2.52943
FBXO5 F-box protein 5 -2.51617
MVD mevalonate (diphospho) decarboxylase -2.5126
PRC1 protein regulator of cytokinesis 1 -2.51167
TRIP13 thyroid hormone receptor interactor 13 -2.50133
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -2.50047
PCCB propionyl CoA carboxylase, beta polypeptide -2.49995
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.49902
BLM Bloom syndrome, RecQ helicase-like -2.49484
CRIPTO3 cripto, EGF-CFC family member 3 -2.49044
TATDN2 TatD DNase domain containing 2 -2.48261
NCAPH non-SMC condensin I complex, subunit H -2.48029
PCYT2 phosphate cytidylyltransferase 2, ethanolamine -2.47096
RFC4 replication factor C (activator 1) 4, 37kDa -2.4654
ANKRD10 ankyrin repeat domain 10 -2.45365
RAD51AP1 RAD51 associated protein 1 -2.45169
PTGES3 prostaglandin E synthase 3 (cytosolic) -2.4485
MRPL11 mitochondrial ribosomal protein L11 -2.44287
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.43393
TFF3 trefoil factor 3 (intestinal) -2.41802
DENND1C DENN/MADD domain containing 1C -2.41165
TROAP trophinin associated protein -2.40632
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 -2.39328
FANCG Fanconi anemia, complementation group G -2.3888
TBX3 T-box 3 -2.37234
RPUSD2 RNA pseudouridylate synthase domain containing 2 -2.35961
NCAPD3 non-SMC condensin II complex, subunit D3 -2.35658
UNG uracil-DNA glycosylase -2.35455
GDF9 growth differentiation factor 9 -2.35455
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.35374
SESN1 sestrin 1 -2.35108
CKS2 CDC28 protein kinase regulatory subunit 2 -2.34968
PIGF phosphatidylinositol glycan anchor biosynthesis, class F -2.34055
MNS1 meiosis-specific nuclear structural 1 -2.33874
HELLS helicase, lymphoid-specific -2.33431
HPX hemopexin -2.33195
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) -2.33156
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) -2.33052
NFYB nuclear transcription factor Y, beta -2.32494
MCM5 minichromosome maintenance complex component 5 -2.3238
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.31625
NEK2 NIMA-related kinase 2 -2.31406
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 -2.31292
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -2.30964
NDC80 NDC80 kinetochore complex component -2.30573
SRSF2 serine/arginine-rich splicing factor 2 -2.30417
CHAF1B chromatin assembly factor 1, subunit B (p60) -2.2954
ERLIN2 ER lipid raft associated 2 -2.29455
ANKRD46 ankyrin repeat domain 46 -2.29421
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 -2.29415
FUS FUS RNA binding protein -2.29082
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 -2.28652
FOXM1 forkhead box M1 -2.28075
DNAAF2 dynein, axonemal, assembly factor 2 -2.27824
SRSF1 serine/arginine-rich splicing factor 1 -2.277
PEX11A peroxisomal biogenesis factor 11 alpha -2.27403
PLA2G2D phospholipase A2, group IID -2.27343
DNM1L dynamin 1-like -2.27243
RAD54L RAD54-like (S. cerevisiae) -2.26955
WRAP53 WD repeat containing, antisense to TP53 -2.26853
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 -2.26791
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1 -2.26448
DUT deoxyuridine triphosphatase -2.25896
TMX1 thioredoxin-related transmembrane protein 1 -2.2575
INCENP inner centromere protein antigens 135/155kDa -2.25706
H2AZ1 H2A.Z variant histone 1 -2.24967
DBF4 DBF4 zinc finger -2.24349
ITGA7 integrin, alpha 7 -2.24344
PTTG1 pituitary tumor-transforming 1 -2.2355
CALCA calcitonin-related polypeptide alpha -2.23336
IFT81 intraflagellar transport 81 -2.23172
HMGB3 high mobility group box 3 -2.23084
CRTAP cartilage associated protein -2.22975
CFAP69 cilia and flagella associated protein 69 -2.22613
PEBP1 phosphatidylethanolamine binding protein 1 -2.21814
TDG thymine-DNA glycosylase -2.21687
ADPRH ADP-ribosylarginine hydrolase -2.21579
VAV3 vav 3 guanine nucleotide exchange factor -2.2142
HMGN3 high mobility group nucleosomal binding domain 3 -2.21339
XPO1 exportin 1 -2.20712
RECQL4 RecQ protein-like 4 -2.20693
PIMREG PICALM interacting mitotic regulator -2.20527
DNA2 DNA replication helicase/nuclease 2 -2.20197
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 -2.19359
HMGB2 high mobility group box 2 -2.18993
TMPO thymopoietin -2.18538
QTRT1 queuine tRNA-ribosyltransferase 1 -2.18212
FKTN fukutin -2.18155
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2 -2.17754
PIGN phosphatidylinositol glycan anchor biosynthesis, class N -2.16861
ABHD14A abhydrolase domain containing 14A -2.16647
E2F8 E2F transcription factor 8 -2.16586
COQ3 coenzyme Q3 methyltransferase -2.16301
WASHC4 WASH complex subunit 4 -2.16073
SHMT1 serine hydroxymethyltransferase 1 (soluble) -2.16056
NCAPG2 non-SMC condensin II complex, subunit G2 -2.1589
ERI2 ERI1 exoribonuclease family member 2 -2.15702
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -2.1504
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.14714
TCERG1 transcription elongation regulator 1 -2.14687
ARID3A AT rich interactive domain 3A (BRIGHT-like) -2.14581
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) -2.14497
CHAD chondroadherin -2.14375
KIF18A kinesin family member 18A -2.14334
MTARC1 mitochondrial amidoxime reducing component 1 -2.13982
CETN2 centrin, EF-hand protein, 2 -2.13944
SLC66A3 solute carrier family 66 member 3 -2.1378
FKBP3 FK506 binding protein 3, 25kDa -2.13454
PCNT pericentrin -2.12589
TOR3A torsin family 3, member A -2.12275
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.1224
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.11997
PRPF4 pre-mRNA processing factor 4 -2.11924
SDF2L1 stromal cell-derived factor 2-like 1 -2.11907
SNRPA small nuclear ribonucleoprotein polypeptide A -2.11566
COG4 component of oligomeric golgi complex 4 -2.11486
KREMEN2 kringle containing transmembrane protein 2 -2.1068
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 -2.09375
RFPL2 ret finger protein-like 2 -2.09217
MAGEC2 melanoma antigen family C2 -2.09183
TOPBP1 topoisomerase (DNA) II binding protein 1 -2.09165
GALR3 galanin receptor 3 -2.09139
TFCP2 transcription factor CP2 -2.09048
VRK1 vaccinia related kinase 1 -2.08644
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 -2.08489
APOC3 apolipoprotein C-III -2.08371
POLE polymerase (DNA directed), epsilon, catalytic subunit -2.08102
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -2.07592
CDC6 cell division cycle 6 -2.07517
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) -2.07141
NLRP2B NLR family pyrin domain containing 2B -2.07035
DONSON downstream neighbor of SON -2.07035
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 -2.06537
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -2.06461
EXO1 exonuclease 1 -2.06217
ELF2 E74-like factor 2 (ets domain transcription factor) -2.05421
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog -2.05402
ZNF180 zinc finger protein 180 -2.05402
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 -2.0539
FN3KRP fructosamine 3 kinase related protein -2.05306
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 -2.05138
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 -2.0503
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.04964
SCML2 sex comb on midleg-like 2 (Drosophila) -2.04422
CLDN15 claudin 15 -2.0423
TBC1D31 TBC1 domain family, member 31 -2.03102
PAGR1 PAXIP1 associated glutamate-rich protein 1 -2.03003
ASGR1 asialoglycoprotein receptor 1 -2.02752
SLC22A14 solute carrier family 22, member 14 -2.02379
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7 -2.02212
CA5A carbonic anhydrase VA, mitochondrial -2.02007
TRIAP1 TP53 regulated inhibitor of apoptosis 1 -2.01783
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.00722
SRSF9 serine/arginine-rich splicing factor 9 -2.00675
CCND3 cyclin D3 -2.00458
PNPLA3 patatin-like phospholipase domain containing 3 -2.00136
RHOH ras homolog family member H -2.00042