CRCGN009_HEPG2_24H:E14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description clotrimazole 10.28 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

120 genes differentially expressed following the CRCGN009_HEPG2_24H:E14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 7.77856
CHMP6 charged multivesicular body protein 6 7.04544
PPARG peroxisome proliferator-activated receptor gamma 6.97458
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 6.21815
SNAP25 synaptosomal-associated protein, 25kDa 6.20168
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 6.08275
MAP7 microtubule-associated protein 7 5.57334
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.25753
CCNF cyclin F 5.22167
TRIB3 tribbles pseudokinase 3 4.778
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 4.66872
ALAS1 5'-aminolevulinate synthase 1 4.6228
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 4.34297
VAT1 vesicle amine transport 1 4.17716
HOXA10 homeobox A10 4.16113
CCDC92 coiled-coil domain containing 92 4.11134
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 3.96262
GPER1 G protein-coupled estrogen receptor 1 3.94417
DDIT4 DNA-damage-inducible transcript 4 3.88295
TATDN2 TatD DNase domain containing 2 3.88237
MYLK myosin light chain kinase 3.84419
PRR15L proline rich 15-like 3.70126
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.59044
NOTCH1 notch 1 3.51497
GATA2 GATA binding protein 2 3.50305
INPP1 inositol polyphosphate-1-phosphatase 3.26674
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.19118
EPHB2 EPH receptor B2 3.12767
EPHA3 EPH receptor A3 2.99033
CIAO3 cytosolic iron-sulfur assembly component 3 2.9569
BAMBI BMP and activin membrane-bound inhibitor 2.83482
GRB10 growth factor receptor-bound protein 10 2.81574
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 2.78506
BACE2 beta-site APP-cleaving enzyme 2 2.75143
ZFP36 ZFP36 ring finger protein 2.71371
FAR2 fatty acyl CoA reductase 2 2.65841
CXCR4 chemokine (C-X-C motif) receptor 4 2.64341
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1 2.60996
CNPY3 canopy FGF signaling regulator 3 2.60301
TXNRD1 thioredoxin reductase 1 2.54591
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.53344
MCUR1 mitochondrial calcium uniporter regulator 1 2.47649
E2F2 E2F transcription factor 2 2.44654
RAP1GAP RAP1 GTPase activating protein 2.32519
GARS1 glycyl-tRNA synthetase 1 2.30127
UBQLN2 ubiquilin 2 2.29925
PLSCR1 phospholipid scramblase 1 2.29744
CDC45 cell division cycle 45 2.29563
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.28503
SQSTM1 sequestosome 1 2.28216
EVL Enah/Vasp-like 2.25881
NFASC neurofascin 2.2526
RUNDC3A RUN domain containing 3A 2.22045
PTCH2 patched 2 2.20543
CPNE7 copine VII 2.19936
ADM2 adrenomedullin 2 2.17541
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 2.1609
EFCC1 EF-hand and coiled-coil domain containing 1 2.15912
CORO1A coronin, actin binding protein, 1A 2.1508
TMEM74B transmembrane protein 74B 2.13883
HOXA10-HOXA9 HOXA10-HOXA9 readthrough 2.13282
DSG2 desmoglein 2 2.12965
KIFC3 kinesin family member C3 2.11739
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 2.11123
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 2.10854
CCP110 centriolar coiled coil protein 110kDa 2.09862
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.05315
ECD ecdysoneless homolog (Drosophila) 2.02682
EVX1 even-skipped homeobox 1 2.02654
INA internexin neuronal intermediate filament protein, alpha 2.02541
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 2.01886
GPSM2 G-protein signaling modulator 2 2.005
PHGDH phosphoglycerate dehydrogenase 2.00199

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -7.22722
CD320 CD320 molecule -6.73951
CCNB2 cyclin B2 -6.69699
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.5855
CCNB1 cyclin B1 -5.35958
PEG10 paternally expressed 10 -5.13448
ADI1 acireductone dioxygenase 1 -4.48795
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.80017
TCTN1 tectonic family member 1 -3.77896
ZNF274 zinc finger protein 274 -3.69886
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.67863
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.60439
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.52062
CHMP4B charged multivesicular body protein 4B -3.47767
ZMIZ1 zinc finger, MIZ-type containing 1 -3.30167
CDK1 cyclin-dependent kinase 1 -3.20982
NRIP1 nuclear receptor interacting protein 1 -2.99898
ALDOC aldolase C, fructose-bisphosphate -2.88982
ITGB1BP1 integrin beta 1 binding protein 1 -2.86627
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.81715
PDZD2 PDZ domain containing 2 -2.75953
EDN1 endothelin 1 -2.75894
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.73254
GNAS GNAS complex locus -2.66449
VDAC1 voltage-dependent anion channel 1 -2.65549
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.62388
FGFR4 fibroblast growth factor receptor 4 -2.60812
CTNND1 catenin (cadherin-associated protein), delta 1 -2.60118
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.59571
PRPF4 pre-mRNA processing factor 4 -2.52589
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.43512
REEP5 receptor accessory protein 5 -2.37099
OXA1L oxidase (cytochrome c) assembly 1-like -2.33842
HMG20B high mobility group 20B -2.30347
KLHDC2 kelch domain containing 2 -2.28092
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.23754
SHCBP1 SHC SH2-domain binding protein 1 -2.19018
UNC119B unc-119 homolog B (C. elegans) -2.13187
RRAS2 related RAS viral (r-ras) oncogene homolog 2 -2.12605
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa -2.07043
EGF epidermal growth factor -2.05683
CCDC106 coiled-coil domain containing 106 -2.04249
RNF111 ring finger protein 111 -2.04145
NOL11 nucleolar protein 11 -2.01736
CDC23 cell division cycle 23 -2.01684
PGAM4 phosphoglycerate mutase family member 4 -2.01457
MELK maternal embryonic leucine zipper kinase -2.01137