CRCGN009_HEPG2_24H:E16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description clotrimazole 2.57 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

40 genes differentially expressed following the CRCGN009_HEPG2_24H:E16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 6.685
SQOR sulfide quinone oxidoreductase 6.52484
ABHD6 abhydrolase domain containing 6 5.0384
LCN2 lipocalin 2 4.44039
LPAR2 lysophosphatidic acid receptor 2 3.97532
KIFBP kinesin family binding protein 3.84471
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.59151
UBQLN2 ubiquilin 2 3.58273
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.28613
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.10109
CIAO3 cytosolic iron-sulfur assembly component 3 3.05969
ADGRE5 adhesion G protein-coupled receptor E5 2.72152
BIRC2 baculoviral IAP repeat containing 2 2.57775
KLHL9 kelch-like family member 9 2.46059
TIAM1 T-cell lymphoma invasion and metastasis 1 2.37072
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.34437
PFKL phosphofructokinase, liver 2.30868
GATA2 GATA binding protein 2 2.25855
RXYLT1 ribitol xylosyltransferase 1 2.23267
PEX11A peroxisomal biogenesis factor 11 alpha 2.18843
PLSCR1 phospholipid scramblase 1 2.11816
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.04987

decreased expression

Symbol Name Standardized Value
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -6.96112
OXA1L oxidase (cytochrome c) assembly 1-like -3.57569
COG2 component of oligomeric golgi complex 2 -3.3745
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.33797
TRIB3 tribbles pseudokinase 3 -3.32046
LDHD lactate dehydrogenase D -3.29954
PEG10 paternally expressed 10 -3.1664
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.95057
HSPB1 heat shock 27kDa protein 1 -2.91168
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.87809
MRPS16 mitochondrial ribosomal protein S16 -2.68396
YME1L1 YME1-like 1 ATPase -2.62321
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.6224
ZW10 zw10 kinetochore protein -2.31155
GNAS GNAS complex locus -2.29996
TLR4 toll-like receptor 4 -2.13101
RAI14 retinoic acid induced 14 -2.12961
PLA2G15 phospholipase A2, group XV -2.12528