CRCGN009_HEPG2_24H:E19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description michler's ketone 39.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

155 genes differentially expressed following the CRCGN009_HEPG2_24H:E19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NOTCH1 notch 1 7.40376
GPER1 G protein-coupled estrogen receptor 1 5.71369
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 5.32064
H2BC12 H2B clustered histone 12 4.90228
CDPF1 cysteine-rich, DPF motif domain containing 1 4.89974
LYN LYN proto-oncogene, Src family tyrosine kinase 4.18559
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.10934
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.02213
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.99852
RPP38 ribonuclease P/MRP 38kDa subunit 3.95392
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.94068
TBPL1 TBP-like 1 3.90824
FRS2 fibroblast growth factor receptor substrate 2 3.89159
ZFP36 ZFP36 ring finger protein 3.72079
H2BC21 H2B clustered histone 21 3.69293
PNKP polynucleotide kinase 3'-phosphatase 3.67535
LPAR2 lysophosphatidic acid receptor 2 3.62381
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.55202
PMM2 phosphomannomutase 2 3.49822
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.46349
SMIM40 small integral membrane protein 40 3.45563
MEST mesoderm specific transcript 3.45409
JADE2 jade family PHD finger 2 3.43025
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.35748
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 3.35478
TIMP2 TIMP metallopeptidase inhibitor 2 3.31184
C2CD2 C2 calcium-dependent domain containing 2 3.21837
AMDHD2 amidohydrolase domain containing 2 3.19472
ATP11B ATPase, class VI, type 11B 3.14818
PTPRK protein tyrosine phosphatase, receptor type, K 3.04935
LCN2 lipocalin 2 2.9299
TENT4A terminal nucleotidyltransferase 4A 2.88162
RAB11FIP2 RAB11 family interacting protein 2 (class I) 2.88003
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.8265
MAP7 microtubule-associated protein 7 2.81315
GHR growth hormone receptor 2.80049
RAI14 retinoic acid induced 14 2.74956
DYNLT3 dynein, light chain, Tctex-type 3 2.67522
H1-2 H1.2 linker histone, cluster member 2.65758
ABHD6 abhydrolase domain containing 6 2.64254
EDN1 endothelin 1 2.61434
ALDOC aldolase C, fructose-bisphosphate 2.61402
GADD45A growth arrest and DNA-damage-inducible, alpha 2.60159
MOK MOK protein kinase 2.58794
SOCS2 suppressor of cytokine signaling 2 2.57996
CTSD cathepsin D 2.56966
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 2.55078
SKIC8 SKI8 subunit of superkiller complex 2.49196
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.46357
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 2.45847
TBC1D31 TBC1 domain family, member 31 2.42209
BAMBI BMP and activin membrane-bound inhibitor 2.37967
TSC22D3 TSC22 domain family, member 3 2.37511
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.36203
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.35988
BAX BCL2-associated X protein 2.33713
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.32986
CAPN1 calpain 1, (mu/I) large subunit 2.30894
RAB21 RAB21, member RAS oncogene family 2.3028
IFNAR1 interferon (alpha, beta and omega) receptor 1 2.28542
MSRA methionine sulfoxide reductase A 2.28461
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.28391
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1 2.27859
AFF4 AF4/FMR2 family, member 4 2.23577
FZD1 frizzled class receptor 1 2.22394
H2BC4 H2B clustered histone 4 2.22263
CYTH2 cytohesin 2 2.21751
TESK1 testis-specific kinase 1 2.20705
TATDN2 TatD DNase domain containing 2 2.20398
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.18517
H2BC9 H2B clustered histone 9 2.1769
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.1689
VAV3 vav 3 guanine nucleotide exchange factor 2.16824
ADGRG1 adhesion G protein-coupled receptor G1 2.16181
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.13356
NXF3 nuclear RNA export factor 3 2.12715
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) 2.12378
FOSL1 FOS-like antigen 1 2.12137
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.11743
LAP3 leucine aminopeptidase 3 2.11104
PRLH prolactin releasing hormone 2.11034
PCDH17 protocadherin 17 2.10637
E4F1 E4F transcription factor 1 2.08025
RING1 ring finger protein 1 2.06643
BRD7 bromodomain containing 7 2.05002
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.04624
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.03436
CCNA1 cyclin A1 2.03017
POLR1D polymerase (RNA) I polypeptide D, 16kDa 2.02828
IL1B interleukin 1, beta 2.02399
TBCC tubulin folding cofactor C 2.02042
MAST3 microtubule associated serine/threonine kinase 3 2.01806
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.01517
XPO4 exportin 4 2.00283

decreased expression

Symbol Name Standardized Value
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -7.19368
LDHD lactate dehydrogenase D -7.02979
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.81231
RPS4Y1 ribosomal protein S4, Y-linked 1 -6.699
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -6.50496
TOP2A topoisomerase (DNA) II alpha 170kDa -5.9314
MELK maternal embryonic leucine zipper kinase -5.92184
UBE2C ubiquitin-conjugating enzyme E2C -5.74187
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -5.09618
CDK1 cyclin-dependent kinase 1 -5.05994
TLR4 toll-like receptor 4 -4.96482
TCTN1 tectonic family member 1 -4.83051
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.53956
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -4.31836
HMGA2 high mobility group AT-hook 2 -4.30222
MRPS2 mitochondrial ribosomal protein S2 -4.29033
PGM1 phosphoglucomutase 1 -4.1825
NT5DC2 5'-nucleotidase domain containing 2 -4.14354
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.03909
CCNB2 cyclin B2 -3.97278
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.90351
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -3.67859
CDC25B cell division cycle 25B -3.3761
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.32255
NNT nicotinamide nucleotide transhydrogenase -3.27855
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -3.16738
DCK deoxycytidine kinase -3.12132
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.12043
CRELD2 cysteine-rich with EGF-like domains 2 -3.06309
SCCPDH saccharopine dehydrogenase (putative) -3.03049
ETFB electron-transfer-flavoprotein, beta polypeptide -2.98552
NISCH nischarin -2.98023
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -2.8555
NPC1 Niemann-Pick disease, type C1 -2.83895
AURKB aurora kinase B -2.79355
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.63205
CRTAP cartilage associated protein -2.58915
CDK4 cyclin-dependent kinase 4 -2.54605
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.51733
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.4322
TBC1D10C TBC1 domain family, member 10C -2.3773
SEC23A Sec23 homolog A (S. cerevisiae) -2.36032
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.33026
CLTC clathrin, heavy chain (Hc) -2.31949
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.29384
CCNA2 cyclin A2 -2.22251
HEATR1 HEAT repeat containing 1 -2.22085
GNAS GNAS complex locus -2.21835
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -2.18971
SHCBP1 SHC SH2-domain binding protein 1 -2.18511
TLCD3A TLC domain containing 3A -2.17883
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.16484
STAT5B signal transducer and activator of transcription 5B -2.15141
SKIC2 SKI2 subunit of superkiller complex -2.14883
UBE2A ubiquitin-conjugating enzyme E2A -2.14159
COG2 component of oligomeric golgi complex 2 -2.13043
CDK6 cyclin-dependent kinase 6 -2.12181
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.0748
RFC2 replication factor C (activator 1) 2, 40kDa -2.01777
GALE UDP-galactose-4-epimerase -2.01161
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.00162