CRCGN009_HEPG2_24H:E20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description michler's ketone 19.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

151 genes differentially expressed following the CRCGN009_HEPG2_24H:E20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 10.0
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 5.78004
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 5.43104
H2BC12 H2B clustered histone 12 4.64683
NOTCH1 notch 1 4.31075
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.11657
MEST mesoderm specific transcript 4.06776
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 4.04922
CIAO3 cytosolic iron-sulfur assembly component 3 3.90333
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.86353
SMIM40 small integral membrane protein 40 3.76637
RAI14 retinoic acid induced 14 3.72037
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.71161
LYN LYN proto-oncogene, Src family tyrosine kinase 3.53643
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.32295
STIMATE STIM activating enhancer 3.31687
H2BC21 H2B clustered histone 21 3.24213
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 3.23219
UBQLN2 ubiquilin 2 3.2267
BLCAP bladder cancer associated protein 3.18736
UBE2L6 ubiquitin-conjugating enzyme E2L 6 3.17114
ZFP36 ZFP36 ring finger protein 3.16662
LCN2 lipocalin 2 3.1528
LPAR2 lysophosphatidic acid receptor 2 2.91909
HTATSF1 HIV-1 Tat specific factor 1 2.89377
PPARG peroxisome proliferator-activated receptor gamma 2.86443
RAB21 RAB21, member RAS oncogene family 2.80795
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.68553
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.67102
CCNA1 cyclin A1 2.64075
PRR15L proline rich 15-like 2.63628
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.62709
NVL nuclear VCP-like 2.58779
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 2.57314
MAST2 microtubule associated serine/threonine kinase 2 2.56021
CTSD cathepsin D 2.50569
TESK1 testis-specific kinase 1 2.4901
PRSS12 protease, serine, 12 (neurotrypsin, motopsin) 2.45649
TBC1D31 TBC1 domain family, member 31 2.45283
TENT4A terminal nucleotidyltransferase 4A 2.44488
NUAK1 NUAK family, SNF1-like kinase, 1 2.40266
FAIM Fas apoptotic inhibitory molecule 2.38474
SNCAIP synuclein, alpha interacting protein 2.37657
MRPL37 mitochondrial ribosomal protein L37 2.36186
KATNIP katanin interacting protein 2.32269
SNX7 sorting nexin 7 2.28833
GATA3 GATA binding protein 3 2.28663
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.28578
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.28426
TERF2IP telomeric repeat binding factor 2, interacting protein 2.273
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 2.26729
PTK2 protein tyrosine kinase 2 2.23785
GRB7 growth factor receptor-bound protein 7 2.23602
HDGFL3 HDGF like 3 2.22258
GADD45A growth arrest and DNA-damage-inducible, alpha 2.22231
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 2.22213
RPGR retinitis pigmentosa GTPase regulator 2.20108
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.19891
BPHL biphenyl hydrolase-like (serine hydrolase) 2.18593
IFNAR1 interferon (alpha, beta and omega) receptor 1 2.1768
AMDHD2 amidohydrolase domain containing 2 2.1606
MAP3K11 mitogen-activated protein kinase kinase kinase 11 2.15263
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 2.1494
ELAC2 elaC ribonuclease Z 2 2.14293
MVP major vault protein 2.11923
EPN3 epsin 3 2.11114
COA7 cytochrome c oxidase assembly factor 7 (putative) 2.10844
WDR45B WD repeat domain 45B 2.10698
ZNF804A zinc finger protein 804A 2.10617
MAP1S microtubule-associated protein 1S 2.10327
PTPRR protein tyrosine phosphatase, receptor type, R 2.09591
MEIS2 Meis homeobox 2 2.08974
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 2.0852
PTPRK protein tyrosine phosphatase, receptor type, K 2.08474
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 2.07593
MEAK7 MTOR associated protein, eak-7 homolog 2.06465
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 2.06315
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.05813
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 2.05295
EDN1 endothelin 1 2.04084
FRS2 fibroblast growth factor receptor substrate 2 2.00929

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.89865
RPS4Y1 ribosomal protein S4, Y-linked 1 -6.58532
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -6.30093
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -6.04121
MELK maternal embryonic leucine zipper kinase -5.71479
TOP2A topoisomerase (DNA) II alpha 170kDa -5.63666
ZNF586 zinc finger protein 586 -5.25197
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -5.03367
CDK1 cyclin-dependent kinase 1 -4.92234
AURKB aurora kinase B -4.67566
DNM1L dynamin 1-like -4.35902
UBE2C ubiquitin-conjugating enzyme E2C -4.1932
ZW10 zw10 kinetochore protein -4.16973
PGM1 phosphoglucomutase 1 -4.1524
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.03054
HMGA2 high mobility group AT-hook 2 -3.96948
CD320 CD320 molecule -3.87163
MRPS16 mitochondrial ribosomal protein S16 -3.64456
PCNA proliferating cell nuclear antigen -3.61624
CDC25B cell division cycle 25B -3.5982
NRIP1 nuclear receptor interacting protein 1 -3.58974
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.36991
TRIB3 tribbles pseudokinase 3 -3.35956
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.19545
NNT nicotinamide nucleotide transhydrogenase -3.18935
TM9SF2 transmembrane 9 superfamily member 2 -3.17345
GLOD4 glyoxalase domain containing 4 -3.14243
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.13725
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.12574
MYC v-myc avian myelocytomatosis viral oncogene homolog -3.0816
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.07107
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.99497
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.98558
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -2.9249
CDK4 cyclin-dependent kinase 4 -2.91291
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.86037
HEATR1 HEAT repeat containing 1 -2.85077
ALDOC aldolase C, fructose-bisphosphate -2.81558
PRPF4 pre-mRNA processing factor 4 -2.80409
RFC2 replication factor C (activator 1) 2, 40kDa -2.62616
TLCD3A TLC domain containing 3A -2.61517
MAPK13 mitogen-activated protein kinase 13 -2.57618
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.52549
GALE UDP-galactose-4-epimerase -2.5068
FBXO7 F-box protein 7 -2.5038
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.50239
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.48481
CELF2 CUGBP, Elav-like family member 2 -2.4657
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.41448
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.40912
GNAS GNAS complex locus -2.37696
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.36977
CLTC clathrin, heavy chain (Hc) -2.31638
TSPAN13 tetraspanin 13 -2.31482
NPR2 natriuretic peptide receptor 2 -2.30178
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.27953
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.25011
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa -2.22353
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa -2.22227
NPC1 Niemann-Pick disease, type C1 -2.20091
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.20065
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -2.2002
SEC61G Sec61 gamma subunit -2.178
COX17 COX17 cytochrome c oxidase copper chaperone -2.16999
COPZ1 coatomer protein complex, subunit zeta 1 -2.14772
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa -2.09286
PHGDH phosphoglycerate dehydrogenase -2.06403
PTBP3 polypyrimidine tract binding protein 3 -2.05591
ZNF562 zinc finger protein 562 -2.03489
CDK2 cyclin-dependent kinase 2 -2.02335