CRCGN009_HEPG2_24H:E21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description michler's ketone 9.9 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

314 genes differentially expressed following the CRCGN009_HEPG2_24H:E21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
H2BC12 H2B clustered histone 12 5.52556
GSTZ1 glutathione S-transferase zeta 1 5.33491
PMM2 phosphomannomutase 2 5.16638
MAP7 microtubule-associated protein 7 5.01735
CYCS cytochrome c, somatic 4.84223
KIFBP kinesin family binding protein 4.28006
CIAO3 cytosolic iron-sulfur assembly component 3 4.20808
RPP38 ribonuclease P/MRP 38kDa subunit 3.95621
TERT telomerase reverse transcriptase 3.77302
TESK1 testis-specific kinase 1 3.66586
MEST mesoderm specific transcript 3.58269
ZW10 zw10 kinetochore protein 3.57338
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.52591
CHMP6 charged multivesicular body protein 6 3.51481
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.50226
UBQLN2 ubiquilin 2 3.47424
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 3.26953
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.21629
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 3.1856
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.17114
SHB Src homology 2 domain containing adaptor protein B 3.11846
RUSC2 RUN and SH3 domain containing 2 3.1
ABHD6 abhydrolase domain containing 6 3.06762
CLDN17 claudin 17 2.96967
BLCAP bladder cancer associated protein 2.94726
CGRRF1 cell growth regulator with ring finger domain 1 2.93299
H2BC21 H2B clustered histone 21 2.92473
SOCS2 suppressor of cytokine signaling 2 2.9235
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.90783
LCN2 lipocalin 2 2.86955
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 2.85321
ARID5B AT rich interactive domain 5B (MRF1-like) 2.83265
TENT4A terminal nucleotidyltransferase 4A 2.83201
CCDC87 coiled-coil domain containing 87 2.81975
FAM246A family with sequence similarity 246 member A 2.77689
ZFP36 ZFP36 ring finger protein 2.76945
CA7 carbonic anhydrase VII 2.76308
ZNF221 zinc finger protein 221 2.75805
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2 2.72443
TAS2R3 taste receptor, type 2, member 3 2.7212
ACTL8 actin-like 8 2.69772
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.65697
TIAM1 T-cell lymphoma invasion and metastasis 1 2.65012
PSG11 pregnancy specific beta-1-glycoprotein 11 2.6409
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.62108
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 2.61993
H2BC9 H2B clustered histone 9 2.615
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 2.61479
NOCT nocturnin 2.6146
RORC RAR-related orphan receptor C 2.60852
IFNAR1 interferon (alpha, beta and omega) receptor 1 2.60614
PLA2G2F phospholipase A2, group IIF 2.55634
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.55612
RAB11FIP1 RAB11 family interacting protein 1 (class I) 2.55343
KIAA1614 KIAA1614 2.53628
VENTX VENT homeobox 2.53211
PFKL phosphofructokinase, liver 2.53145
TEX13B testis expressed 13B 2.52969
ZNF446 zinc finger protein 446 2.52947
USB1 U6 snRNA biogenesis 1 2.52614
PRDM14 PR domain containing 14 2.52154
FOSL1 FOS-like antigen 1 2.52094
OR2C1 olfactory receptor, family 2, subfamily C, member 1 2.50927
BRSK2 BR serine/threonine kinase 2 2.50861
CTSD cathepsin D 2.49154
GDF3 growth differentiation factor 3 2.49096
RAB21 RAB21, member RAS oncogene family 2.48425
STIMATE STIM activating enhancer 2.47104
GJB4 gap junction protein, beta 4, 30.3kDa 2.46297
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 2.4538
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 2.45376
GPR176 G protein-coupled receptor 176 2.4496
COA7 cytochrome c oxidase assembly factor 7 (putative) 2.44938
TMEM143 transmembrane protein 143 2.44385
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 2.44022
TIMP2 TIMP metallopeptidase inhibitor 2 2.43141
PAX1 paired box 1 2.42838
RAI14 retinoic acid induced 14 2.41697
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1 2.4129
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase) 2.40654
IL25 interleukin 25 2.40604
MYLK myosin light chain kinase 2.40343
CRX cone-rod homeobox 2.39209
HOXA10 homeobox A10 2.38893
PCDHGB5 protocadherin gamma subfamily B, 5 2.37662
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.37637
HEBP1 heme binding protein 1 2.36392
MOB3B MOB kinase activator 3B 2.3636
IQSEC2 IQ motif and Sec7 domain 2 2.3433
CNTN2 contactin 2 (axonal) 2.34004
NTSR1 neurotensin receptor 1 (high affinity) 2.33709
DNAH6 dynein, axonemal, heavy chain 6 2.32425
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 2.32285
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 2.31994
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 2.3147
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 2.30663
HOXB1 homeobox B1 2.29955
DIPK2B divergent protein kinase domain 2B 2.29886
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.29841
NPDC1 neural proliferation, differentiation and control, 1 2.29326
EDA2R ectodysplasin A2 receptor 2.28632
VRTN vertebrae development associated 2.28018
ULBP2 UL16 binding protein 2 2.27909
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 2.27444
KRT32 keratin 32, type I 2.27132
FOXH1 forkhead box H1 2.26511
SKIC8 SKI8 subunit of superkiller complex 2.26481
BTNL2 butyrophilin-like 2 2.26356
RNF122 ring finger protein 122 2.26325
FSCN1 fascin actin-bundling protein 1 2.26076
CCDC33 coiled-coil domain containing 33 2.25905
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 2.25459
ALX4 ALX homeobox 4 2.2472
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 2.24672
NEU3 sialidase 3 (membrane sialidase) 2.23693
SCN8A sodium channel, voltage gated, type VIII alpha subunit 2.2347
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 2.2253
PCDHGA1 protocadherin gamma subfamily A, 1 2.22491
PGLYRP1 peptidoglycan recognition protein 1 2.2242
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 2.22334
PLCH2 phospholipase C, eta 2 2.21507
GAS2L1 growth arrest-specific 2 like 1 2.21227
SPIN2A spindlin family, member 2A 2.21031
LY6G6C lymphocyte antigen 6 complex, locus G6C 2.21026
PACC1 proton activated chloride channel 1 2.20476
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 2.20043
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1 2.19956
UFC1 ubiquitin-fold modifier conjugating enzyme 1 2.19411
PRAMEF10 PRAME family member 10 2.1929
BRME1 break repair meiotic recombinase recruitment factor 1 2.19212
GPR21 G protein-coupled receptor 21 2.18844
ODAD2 outer dynein arm docking complex subunit 2 2.18622
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.18534
AMH anti-Mullerian hormone 2.17732
ZYX zyxin 2.17715
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.17226
EFR3B EFR3 homolog B (S. cerevisiae) 2.17152
AMBN ameloblastin (enamel matrix protein) 2.16798
VAC14 Vac14 homolog (S. cerevisiae) 2.16733
PODNL1 podocan-like 1 2.1636
ARSF arylsulfatase F 2.16322
NR5A1 nuclear receptor subfamily 5, group A, member 1 2.16124
RGSL1 regulator of G-protein signaling like 1 2.15934
GADD45A growth arrest and DNA-damage-inducible, alpha 2.15922
FKBPL FK506 binding protein like 2.15616
PSRC1 proline/serine-rich coiled-coil 1 2.15494
NXPH4 neurexophilin 4 2.15389
GJA8 gap junction protein, alpha 8, 50kDa 2.15361
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.1531
G6PC2 glucose-6-phosphatase, catalytic, 2 2.15162
KATNIP katanin interacting protein 2.1454
ZNF74 zinc finger protein 74 2.14474
KIR2DS2 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2 2.14316
RBM8A RNA binding motif protein 8A 2.14297
ALOXE3 arachidonate lipoxygenase 3 2.1406
KRTAP2-3 keratin associated protein 2-3 2.13458
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 2.13388
A4GNT alpha-1,4-N-acetylglucosaminyltransferase 2.12807
NRIP2 nuclear receptor interacting protein 2 2.12771
MMP24 matrix metallopeptidase 24 (membrane-inserted) 2.12639
ZFR2 zinc finger RNA binding protein 2 2.12467
OR3A3 olfactory receptor, family 3, subfamily A, member 3 2.12445
GPATCH8 G patch domain containing 8 2.12442
FURIN furin (paired basic amino acid cleaving enzyme) 2.12324
INHBC inhibin, beta C 2.12264
MOSPD3 motile sperm domain containing 3 2.12223
CEMIP2 cell migration inducing hyaluronidase 2 2.12075
ASCL3 achaete-scute family bHLH transcription factor 3 2.11359
IRF2BP1 interferon regulatory factor 2 binding protein 1 2.11289
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa 2.11257
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.10967
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 2.10869
FRS2 fibroblast growth factor receptor substrate 2 2.10836
HHLA1 HERV-H LTR-associating 1 2.10831
EN2 engrailed homeobox 2 2.10542
GRM2 glutamate receptor, metabotropic 2 2.10417
HTATSF1 HIV-1 Tat specific factor 1 2.10407
RGL4 ral guanine nucleotide dissociation stimulator-like 4 2.10404
MILR1 mast cell immunoglobulin-like receptor 1 2.10164
TAAR5 trace amine associated receptor 5 2.09928
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 2.09844
EPHB2 EPH receptor B2 2.09483
ZBTB22 zinc finger and BTB domain containing 22 2.0918
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 2.09068
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa 2.08572
ZC3H3 zinc finger CCCH-type containing 3 2.08463
AKAP5 A kinase (PRKA) anchor protein 5 2.08405
PTK2 protein tyrosine kinase 2 2.08324
CCNC cyclin C 2.08005
ARR3 arrestin 3, retinal (X-arrestin) 2.07776
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 2.07682
CNOT3 CCR4-NOT transcription complex, subunit 3 2.07667
TRPM6 transient receptor potential cation channel, subfamily M, member 6 2.07523
GAST gastrin 2.07512
NPFFR1 neuropeptide FF receptor 1 2.07265
TNFAIP8L2-SCNM1 TNFAIP8L2-SCNM1 readthrough 2.07256
CMKLR2 chemerin chemokine-like receptor 2 2.06925
EBNA1BP2 EBNA1 binding protein 2 2.06907
ZNF154 zinc finger protein 154 2.06407
ORC3 origin recognition complex, subunit 3 2.06364
PTK2B protein tyrosine kinase 2 beta 2.0632
EPHA1 EPH receptor A1 2.06251
HEYL hes-related family bHLH transcription factor with YRPW motif-like 2.06066
ADGRG1 adhesion G protein-coupled receptor G1 2.0569
ZSCAN2 zinc finger and SCAN domain containing 2 2.0534
SIRPA signal-regulatory protein alpha 2.05307
PSME3IP1 proteasome activator subunit 3 interacting protein 1 2.04945
PCDHA9 protocadherin alpha 9 2.04898
ADAM11 ADAM metallopeptidase domain 11 2.04686
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 2.038
OR2H1 olfactory receptor, family 2, subfamily H, member 1 2.03794
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 2.03651
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor 2.0364
FZD1 frizzled class receptor 1 2.03399
OPN1MW3 opsin 1, medium wave sensitive 3 2.0335
CES3 carboxylesterase 3 2.03288
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 2.03271
INSRR insulin receptor-related receptor 2.03138
ARL4C ADP-ribosylation factor-like 4C 2.02975
H1-2 H1.2 linker histone, cluster member 2.02753
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B 2.02541
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 2.02515
CLCN4 chloride channel, voltage-sensitive 4 2.02208
MUC3B mucin 3B, cell surface associated 2.0219
SIGLEC5 sialic acid binding Ig-like lectin 5 2.02112
SPRED2 sprouty-related, EVH1 domain containing 2 2.01942
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.01934
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase 2.01708
TBX5 T-box 5 2.01424
CLEC5A C-type lectin domain family 5, member A 2.0115
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 2.01062
MRM2 mitochondrial rRNA methyltransferase 2 2.00804
ASIC3 acid sensing (proton gated) ion channel 3 2.00724
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 2.00642
ONECUT1 one cut homeobox 1 2.00622
SMIM8 small integral membrane protein 8 2.00602
PPP1R17 protein phosphatase 1, regulatory subunit 17 2.00439
GBX2 gastrulation brain homeobox 2 2.00431

decreased expression

Symbol Name Standardized Value
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -6.62191
CD320 CD320 molecule -6.60975
UBE2C ubiquitin-conjugating enzyme E2C -5.74851
TOP2A topoisomerase (DNA) II alpha 170kDa -5.43769
MELK maternal embryonic leucine zipper kinase -5.36681
LOC124907782 dual specificity protein phosphatase 22 -5.33518
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -5.32888
GNAS GNAS complex locus -5.27187
NRIP1 nuclear receptor interacting protein 1 -5.1257
CDK1 cyclin-dependent kinase 1 -5.05827
RPN1 ribophorin I -4.85296
HMGA2 high mobility group AT-hook 2 -4.65005
PGM1 phosphoglucomutase 1 -4.36432
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -4.32688
ADI1 acireductone dioxygenase 1 -4.00187
SCCPDH saccharopine dehydrogenase (putative) -3.88833
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.59187
NNT nicotinamide nucleotide transhydrogenase -3.45493
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -3.44442
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.40666
HAT1 histone acetyltransferase 1 -3.38691
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -3.20615
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.19125
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.18531
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.14406
CDK4 cyclin-dependent kinase 4 -3.10508
MYC v-myc avian myelocytomatosis viral oncogene homolog -2.9708
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.95215
EGF epidermal growth factor -2.89992
ALDOC aldolase C, fructose-bisphosphate -2.89112
RBM14-RBM4 RBM14-RBM4 readthrough -2.88511
PNKP polynucleotide kinase 3'-phosphatase -2.86113
CDC45 cell division cycle 45 -2.83923
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -2.79399
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.76615
HEATR1 HEAT repeat containing 1 -2.76537
ETFB electron-transfer-flavoprotein, beta polypeptide -2.7496
TCTN1 tectonic family member 1 -2.72324
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.70879
UBE2A ubiquitin-conjugating enzyme E2A -2.70501
EIF5 eukaryotic translation initiation factor 5 -2.68208
TBC1D10C TBC1 domain family, member 10C -2.66741
PARP1 poly (ADP-ribose) polymerase 1 -2.55825
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.53606
CHEK2 checkpoint kinase 2 -2.51766
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -2.48837
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.48569
NISCH nischarin -2.44878
ICAM3 intercellular adhesion molecule 3 -2.44019
RSU1 Ras suppressor protein 1 -2.41358
CPNE3 copine III -2.39251
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -2.39113
CHIC2 cysteine-rich hydrophobic domain 2 -2.34153
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -2.32641
HYOU1 hypoxia up-regulated 1 -2.26997
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.25929
HADH hydroxyacyl-CoA dehydrogenase -2.25429
ACOT2 acyl-CoA thioesterase 2 -2.23659
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.22971
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.2093
GLOD4 glyoxalase domain containing 4 -2.20164
ADGRE5 adhesion G protein-coupled receptor E5 -2.20077
FBXO7 F-box protein 7 -2.20043
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -2.16508
LOC112694756 uncharaterized LOC112694756 -2.14536
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -2.13812
RPN2 ribophorin II -2.13808
TOMM70 translocase of outer mitochondrial membrane 70 -2.13329
RABAC1 Rab acceptor 1 (prenylated) -2.12517
ANKRD17 ankyrin repeat domain 17 -2.10887
GPD1L glycerol-3-phosphate dehydrogenase 1-like -2.04751
TCIM transcriptional and immune response regulator -2.03472
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 -2.02516
INTS6 integrator complex subunit 6 -2.01552
MEPCE methylphosphate capping enzyme -2.00653
BLMH bleomycin hydrolase -2.00106