| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | michler's ketone 4.95 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
| Downloads & Tools |
139 genes differentially expressed following the CRCGN009_HEPG2_24H:E22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| E2F2 | E2F transcription factor 2 | 6.77389 |
| AMDHD2 | amidohydrolase domain containing 2 | 5.64356 |
| LCN2 | lipocalin 2 | 5.08397 |
| NOTCH1 | notch 1 | 4.3821 |
| H2BC12 | H2B clustered histone 12 | 4.16872 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 4.14522 |
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 4.12772 |
| ATP11B | ATPase, class VI, type 11B | 3.92651 |
| RPP38 | ribonuclease P/MRP 38kDa subunit | 3.86169 |
| MCOLN1 | mucolipin 1 | 3.86048 |
| ZW10 | zw10 kinetochore protein | 3.79321 |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | 3.76566 |
| GARRE1 | granule associated Rac and RHOG effector 1 | 3.32769 |
| UBQLN2 | ubiquilin 2 | 3.32733 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 3.19836 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | 3.16142 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 3.13647 |
| CHMP6 | charged multivesicular body protein 6 | 3.05622 |
| GDPD5 | glycerophosphodiester phosphodiesterase domain containing 5 | 3.00553 |
| DIPK1A | divergent protein kinase domain 1A | 2.94643 |
| NVL | nuclear VCP-like | 2.8664 |
| EDN1 | endothelin 1 | 2.84038 |
| SOCS2 | suppressor of cytokine signaling 2 | 2.82476 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 2.8092 |
| RPS6KA1 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 2.80233 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 2.78014 |
| MEST | mesoderm specific transcript | 2.75283 |
| MKNK1 | MAP kinase interacting serine/threonine kinase 1 | 2.70266 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 2.68926 |
| CPSF4 | cleavage and polyadenylation specific factor 4, 30kDa | 2.65722 |
| CCL2 | chemokine (C-C motif) ligand 2 | 2.63972 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 2.56348 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 2.53619 |
| H2BC21 | H2B clustered histone 21 | 2.51137 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 2.49129 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 2.47831 |
| PLSCR3 | phospholipid scramblase 3 | 2.46258 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 2.45878 |
| CYCS | cytochrome c, somatic | 2.44376 |
| TPD52L2 | tumor protein D52-like 2 | 2.4411 |
| SNX7 | sorting nexin 7 | 2.44032 |
| PLS1 | plastin 1 | 2.43305 |
| MINDY1 | MINDY lysine 48 deubiquitinase 1 | 2.3961 |
| EBNA1BP2 | EBNA1 binding protein 2 | 2.38975 |
| RENBP | renin binding protein | 2.38617 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | 2.38038 |
| DNAJB4 | DnaJ (Hsp40) homolog, subfamily B, member 4 | 2.36256 |
| REG1A | regenerating islet-derived 1 alpha | 2.32144 |
| TBXA2R | thromboxane A2 receptor | 2.31688 |
| STAB1 | stabilin 1 | 2.28345 |
| CTSD | cathepsin D | 2.27623 |
| MAP7 | microtubule-associated protein 7 | 2.26698 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 2.26575 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 2.26089 |
| ARL2BP | ADP-ribosylation factor-like 2 binding protein | 2.25656 |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | 2.2068 |
| MVP | major vault protein | 2.19884 |
| INPP1 | inositol polyphosphate-1-phosphatase | 2.19358 |
| H1-2 | H1.2 linker histone, cluster member | 2.17279 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | 2.17263 |
| PSRC1 | proline/serine-rich coiled-coil 1 | 2.15926 |
| CBR3 | carbonyl reductase 3 | 2.06731 |
| SLC4A1AP | solute carrier family 4 (anion exchanger), member 1, adaptor protein | 2.06419 |
| H2BC11 | H2B clustered histone 11 | 2.06046 |
| DEF8 | differentially expressed in FDCP 8 homolog (mouse) | 2.03878 |
| PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | 2.03036 |
| SLC35F6 | solute carrier family 35, member F6 | 2.02014 |
| GABRB2 | gamma-aminobutyric acid (GABA) A receptor, beta 2 | 2.01371 |
| PTK2 | protein tyrosine kinase 2 | 2.01312 |
| IL1RAPL2 | interleukin 1 receptor accessory protein-like 2 | 2.01233 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -5.94239 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -5.8612 |
| MELK | maternal embryonic leucine zipper kinase | -5.57365 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -5.49519 |
| CDK1 | cyclin-dependent kinase 1 | -5.35152 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -4.90595 |
| HMGA2 | high mobility group AT-hook 2 | -4.5614 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -4.42857 |
| TLCD3A | TLC domain containing 3A | -4.05111 |
| PGM1 | phosphoglucomutase 1 | -4.03576 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -3.9964 |
| AURKB | aurora kinase B | -3.80385 |
| HEATR1 | HEAT repeat containing 1 | -3.52294 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -3.50782 |
| PCNA | proliferating cell nuclear antigen | -3.5048 |
| EGF | epidermal growth factor | -3.3115 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | -3.25795 |
| UBE3C | ubiquitin protein ligase E3C | -3.21333 |
| ACAA1 | acetyl-CoA acyltransferase 1 | -3.19812 |
| CCNB2 | cyclin B2 | -3.07723 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -3.01373 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -2.95097 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -2.94722 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | -2.9161 |
| TLR4 | toll-like receptor 4 | -2.89284 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.83331 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -2.81204 |
| ALDOC | aldolase C, fructose-bisphosphate | -2.67725 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | -2.65226 |
| UBE2A | ubiquitin-conjugating enzyme E2A | -2.63119 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -2.62173 |
| FGFR4 | fibroblast growth factor receptor 4 | -2.61714 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -2.58386 |
| TCTN1 | tectonic family member 1 | -2.56087 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | -2.5541 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | -2.54887 |
| PSMG1 | proteasome (prosome, macropain) assembly chaperone 1 | -2.51927 |
| TMED10 | transmembrane emp24-like trafficking protein 10 (yeast) | -2.49335 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -2.48388 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | -2.48261 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -2.47347 |
| HYOU1 | hypoxia up-regulated 1 | -2.40369 |
| RBM14-RBM4 | RBM14-RBM4 readthrough | -2.33513 |
| TCERG1 | transcription elongation regulator 1 | -2.32087 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | -2.31704 |
| SRP54 | signal recognition particle 54kDa | -2.28826 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -2.26391 |
| RBM47 | RNA binding motif protein 47 | -2.25508 |
| CDC45 | cell division cycle 45 | -2.22568 |
| TBC1D10C | TBC1 domain family, member 10C | -2.21711 |
| GALE | UDP-galactose-4-epimerase | -2.21443 |
| NISCH | nischarin | -2.20367 |
| GNAS | GNAS complex locus | -2.17106 |
| LOC124907782 | dual specificity protein phosphatase 22 | -2.17027 |
| KIF18B | kinesin family member 18B | -2.16385 |
| CDK4 | cyclin-dependent kinase 4 | -2.16045 |
| NCOA4 | nuclear receptor coactivator 4 | -2.15522 |
| USP6NL | USP6 N-terminal like | -2.11512 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -2.10474 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | -2.10136 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -2.08378 |
| B4GAT1 | beta-1,4-glucuronyltransferase 1 | -2.06138 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | -2.04739 |
| MYLK | myosin light chain kinase | -2.03064 |
| RACGAP1 | Rac GTPase activating protein 1 | -2.02491 |
| SETD3 | SET domain containing 3 | -2.02412 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -2.02027 |
| PSMD10 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 | -2.01165 |
| NNT | nicotinamide nucleotide transhydrogenase | -2.00622 |
