| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | michler's ketone 2.47 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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118 genes differentially expressed following the CRCGN009_HEPG2_24H:E23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 5.35951 |
| H2BC12 | H2B clustered histone 12 | 4.26759 |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | 4.04495 |
| MEST | mesoderm specific transcript | 3.82707 |
| STK10 | serine/threonine kinase 10 | 3.5294 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 3.46095 |
| ZW10 | zw10 kinetochore protein | 3.45397 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | 3.44072 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 3.33433 |
| LAGE3 | L antigen family, member 3 | 3.24209 |
| AXIN1 | axin 1 | 3.23502 |
| EPHA3 | EPH receptor A3 | 3.16416 |
| LCN2 | lipocalin 2 | 3.16358 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 3.14361 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 3.09256 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 3.07256 |
| CPSF4 | cleavage and polyadenylation specific factor 4, 30kDa | 3.03357 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 3.00584 |
| BLCAP | bladder cancer associated protein | 2.96658 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 2.94365 |
| DIPK1A | divergent protein kinase domain 1A | 2.88327 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | 2.76497 |
| SLC27A3 | solute carrier family 27 (fatty acid transporter), member 3 | 2.59256 |
| TRAPPC6A | trafficking protein particle complex 6A | 2.59072 |
| TBC1D31 | TBC1 domain family, member 31 | 2.5734 |
| NOTCH1 | notch 1 | 2.47045 |
| H2BC21 | H2B clustered histone 21 | 2.41766 |
| TENT4A | terminal nucleotidyltransferase 4A | 2.35843 |
| FOSL1 | FOS-like antigen 1 | 2.30752 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 2.29913 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 2.27706 |
| INPP1 | inositol polyphosphate-1-phosphatase | 2.27392 |
| MYLK | myosin light chain kinase | 2.25888 |
| CTSD | cathepsin D | 2.2559 |
| SMNDC1 | survival motor neuron domain containing 1 | 2.25466 |
| PAF1 | Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) | 2.2523 |
| RAI14 | retinoic acid induced 14 | 2.2185 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 2.21197 |
| TESK1 | testis-specific kinase 1 | 2.21074 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 2.20442 |
| MAP7 | microtubule-associated protein 7 | 2.18749 |
| EDN1 | endothelin 1 | 2.15065 |
| RTF2 | replication termination factor 2 | 2.1362 |
| ABHD6 | abhydrolase domain containing 6 | 2.13126 |
| SFTPB | surfactant protein B | 2.12793 |
| IFNAR1 | interferon (alpha, beta and omega) receptor 1 | 2.09544 |
| STUB1 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase | 2.08675 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 2.07392 |
| TPD52L2 | tumor protein D52-like 2 | 2.07129 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 2.06012 |
| PLA2G12A | phospholipase A2, group XIIA | 2.0524 |
| EED | embryonic ectoderm development | 2.03312 |
| ZFP36 | ZFP36 ring finger protein | 2.03004 |
| GK2 | glycerol kinase 2 | 2.02955 |
| PSRC1 | proline/serine-rich coiled-coil 1 | 2.02925 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 2.02141 |
| DDX10 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 | 2.01582 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LDHD | lactate dehydrogenase D | -10.0 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -5.64885 |
| MELK | maternal embryonic leucine zipper kinase | -5.55478 |
| CDK1 | cyclin-dependent kinase 1 | -5.22117 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -4.84039 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -4.77694 |
| HMGA2 | high mobility group AT-hook 2 | -4.57799 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -3.96112 |
| PGM1 | phosphoglucomutase 1 | -3.6652 |
| TRIB3 | tribbles pseudokinase 3 | -3.63297 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | -3.33096 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -3.31162 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -3.21261 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -3.20663 |
| ICAM3 | intercellular adhesion molecule 3 | -3.15877 |
| AURKB | aurora kinase B | -3.13153 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | -3.02871 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -3.0094 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | -2.96894 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -2.93493 |
| TLCD3A | TLC domain containing 3A | -2.91118 |
| CDK4 | cyclin-dependent kinase 4 | -2.79643 |
| ALDOC | aldolase C, fructose-bisphosphate | -2.74263 |
| HEATR1 | HEAT repeat containing 1 | -2.7257 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -2.65062 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -2.60032 |
| NCK1 | NCK adaptor protein 1 | -2.58277 |
| DCK | deoxycytidine kinase | -2.57824 |
| NPC1 | Niemann-Pick disease, type C1 | -2.56055 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -2.49678 |
| ACAA1 | acetyl-CoA acyltransferase 1 | -2.48082 |
| TMED10 | transmembrane emp24-like trafficking protein 10 (yeast) | -2.46896 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -2.42724 |
| COPS7A | COP9 signalosome subunit 7A | -2.39145 |
| EDEM1 | ER degradation enhancer, mannosidase alpha-like 1 | -2.38306 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | -2.33814 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -2.33 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | -2.32974 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -2.32088 |
| UBE3C | ubiquitin protein ligase E3C | -2.29615 |
| TOPBP1 | topoisomerase (DNA) II binding protein 1 | -2.28773 |
| CDC20 | cell division cycle 20 | -2.27098 |
| CSK | c-src tyrosine kinase | -2.26867 |
| NISCH | nischarin | -2.26321 |
| PSMG1 | proteasome (prosome, macropain) assembly chaperone 1 | -2.25422 |
| BIRC2 | baculoviral IAP repeat containing 2 | -2.24462 |
| DNTTIP2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | -2.22339 |
| NNT | nicotinamide nucleotide transhydrogenase | -2.20593 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | -2.20145 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -2.19497 |
| EIF5 | eukaryotic translation initiation factor 5 | -2.18469 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -2.15909 |
| DEPDC5 | DEP domain containing 5 | -2.12779 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | -2.09927 |
| TYK2 | tyrosine kinase 2 | -2.072 |
| NAMPT | nicotinamide phosphoribosyltransferase | -2.03752 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | -2.02849 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | -2.02505 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | -2.01651 |
| CHPT1 | choline phosphotransferase 1 | -2.00598 |
| NR2F6 | nuclear receptor subfamily 2, group F, member 6 | -2.00392 |
