CRCGN009_HEPG2_24H:E24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description michler's ketone 1.24 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

109 genes differentially expressed following the CRCGN009_HEPG2_24H:E24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 7.30062
LCN2 lipocalin 2 6.77837
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.5497
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.46916
NOTCH1 notch 1 4.26262
KIFBP kinesin family binding protein 4.03811
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.03037
PMM2 phosphomannomutase 2 3.99185
GARRE1 granule associated Rac and RHOG effector 1 3.91076
H2BC12 H2B clustered histone 12 3.68713
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.67913
MEST mesoderm specific transcript 3.66795
RPP38 ribonuclease P/MRP 38kDa subunit 3.54381
CHMP6 charged multivesicular body protein 6 3.25591
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.13381
GSTZ1 glutathione S-transferase zeta 1 3.02853
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.00145
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.92516
STIMATE STIM activating enhancer 2.91624
BLCAP bladder cancer associated protein 2.85592
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.83598
TENT4A terminal nucleotidyltransferase 4A 2.82427
ADRB2 adrenoceptor beta 2, surface 2.81578
OLFM4 olfactomedin 4 2.59838
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.5978
SLC75A1 solute carrier family 75 member 1 2.57306
ICE1 interactor of little elongation complex ELL subunit 1 2.54145
CBR3 carbonyl reductase 3 2.53327
MSRA methionine sulfoxide reductase A 2.51099
INPP1 inositol polyphosphate-1-phosphatase 2.42983
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.34737
EDN1 endothelin 1 2.28841
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.28444
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.24888
EGF epidermal growth factor 2.23308
MAP7 microtubule-associated protein 7 2.22162
NR3C2 nuclear receptor subfamily 3, group C, member 2 2.19308
ATP11B ATPase, class VI, type 11B 2.18792
H2BC21 H2B clustered histone 21 2.18127
ISOC1 isochorismatase domain containing 1 2.17137
FOSL1 FOS-like antigen 1 2.15222
IQGAP1 IQ motif containing GTPase activating protein 1 2.06138
MVP major vault protein 2.05856
H2AC19 H2A clustered histone 19 2.04894
GPATCH8 G patch domain containing 8 2.04584
PFKL phosphofructokinase, liver 2.04564
CCP110 centriolar coiled coil protein 110kDa 2.03927
PPP1R17 protein phosphatase 1, regulatory subunit 17 2.00623

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.43684
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -5.68363
TOP2A topoisomerase (DNA) II alpha 170kDa -5.57742
LOC124907782 dual specificity protein phosphatase 22 -5.15748
CDK1 cyclin-dependent kinase 1 -5.09203
MELK maternal embryonic leucine zipper kinase -5.0777
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -4.38089
PECR peroxisomal trans-2-enoyl-CoA reductase -4.35066
COPS7A COP9 signalosome subunit 7A -4.12012
UBE2C ubiquitin-conjugating enzyme E2C -4.10971
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.03763
FBXL12 F-box and leucine-rich repeat protein 12 -4.01205
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -3.80053
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.7806
PGM1 phosphoglucomutase 1 -3.72683
HMGA2 high mobility group AT-hook 2 -3.71752
NRIP1 nuclear receptor interacting protein 1 -3.6239
HYOU1 hypoxia up-regulated 1 -3.56355
CSK c-src tyrosine kinase -3.55667
ZDHHC6 zinc finger, DHHC-type containing 6 -3.51023
PCNA proliferating cell nuclear antigen -3.48753
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.42979
TRIB3 tribbles pseudokinase 3 -3.40069
ADI1 acireductone dioxygenase 1 -3.21873
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.21068
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -3.10788
UGDH UDP-glucose 6-dehydrogenase -3.0701
EIF5 eukaryotic translation initiation factor 5 -3.04008
HEATR1 HEAT repeat containing 1 -2.94072
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.93948
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.88947
HNRNPF heterogeneous nuclear ribonucleoprotein F -2.76032
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.73123
CHIC2 cysteine-rich hydrophobic domain 2 -2.63785
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.55362
OXA1L oxidase (cytochrome c) assembly 1-like -2.49001
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.48977
TCTN1 tectonic family member 1 -2.44663
YME1L1 YME1-like 1 ATPase -2.44578
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -2.39006
STAMBP STAM binding protein -2.37125
SNX11 sorting nexin 11 -2.34868
ALDOC aldolase C, fructose-bisphosphate -2.32708
DERA deoxyribose-phosphate aldolase (putative) -2.29064
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide -2.25132
ANXA6 annexin A6 -2.20715
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.18742
CDK4 cyclin-dependent kinase 4 -2.18453
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -2.17787
TMPRSS11D transmembrane protease, serine 11D -2.17254
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.1514
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.1326
PLP1 proteolipid protein 1 -2.1318
NISCH nischarin -2.12824
CDC20 cell division cycle 20 -2.10527
SCCPDH saccharopine dehydrogenase (putative) -2.09504
CES1 carboxylesterase 1 -2.08164
GNAS GNAS complex locus -2.06577
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -2.04757
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.02562
SLC35F2 solute carrier family 35, member F2 -2.02222