| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | potassium 1h-indol-3-yl sulfate 21.71 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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229 genes differentially expressed following the CRCGN009_HEPG2_24H:F01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 10.0 |
| ABHD4 | abhydrolase domain containing 4 | 8.85305 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 8.03595 |
| HMOX1 | heme oxygenase 1 | 7.96856 |
| SQOR | sulfide quinone oxidoreductase | 6.92368 |
| CHMP6 | charged multivesicular body protein 6 | 6.92198 |
| CNPY3 | canopy FGF signaling regulator 3 | 6.84633 |
| RAP1GAP | RAP1 GTPase activating protein | 6.54929 |
| MVP | major vault protein | 5.72142 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 5.44399 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 5.30658 |
| SORBS3 | sorbin and SH3 domain containing 3 | 5.15151 |
| ANO10 | anoctamin 10 | 5.06897 |
| MAP7 | microtubule-associated protein 7 | 4.89257 |
| ZFP36 | ZFP36 ring finger protein | 4.82876 |
| SQSTM1 | sequestosome 1 | 4.6436 |
| CTSL | cathepsin L | 4.45531 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 4.31893 |
| CBR3 | carbonyl reductase 3 | 4.30292 |
| INPP1 | inositol polyphosphate-1-phosphatase | 4.10844 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 4.08756 |
| RPS6KA1 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 3.9994 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 3.91526 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 3.88929 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | 3.87132 |
| FOSL1 | FOS-like antigen 1 | 3.8372 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 3.66291 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 3.63578 |
| KEAP1 | kelch-like ECH-associated protein 1 | 3.54244 |
| E2F2 | E2F transcription factor 2 | 3.40401 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 3.37242 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | 3.33551 |
| NUCB2 | nucleobindin 2 | 3.33214 |
| PNKP | polynucleotide kinase 3'-phosphatase | 3.30129 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 3.18194 |
| NANOS3 | nanos homolog 3 (Drosophila) | 3.04291 |
| STX1A | syntaxin 1A (brain) | 3.03136 |
| PRR15L | proline rich 15-like | 2.97458 |
| BMP4 | bone morphogenetic protein 4 | 2.9606 |
| STAP2 | signal transducing adaptor family member 2 | 2.95631 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 2.95298 |
| BAG3 | BCL2-associated athanogene 3 | 2.91155 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 2.9065 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 2.88292 |
| STX4 | syntaxin 4 | 2.88257 |
| FAIM | Fas apoptotic inhibitory molecule | 2.86749 |
| GSTZ1 | glutathione S-transferase zeta 1 | 2.85529 |
| PFKL | phosphofructokinase, liver | 2.83085 |
| TPRA1 | transmembrane protein, adipocyte asscociated 1 | 2.78454 |
| CBR1 | carbonyl reductase 1 | 2.74419 |
| GPER1 | G protein-coupled estrogen receptor 1 | 2.71739 |
| POLD4 | polymerase (DNA-directed), delta 4, accessory subunit | 2.63516 |
| TBC1D10C | TBC1 domain family, member 10C | 2.62474 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 2.61772 |
| KLHL21 | kelch-like family member 21 | 2.58758 |
| DUSP6 | dual specificity phosphatase 6 | 2.5762 |
| PSMB8 | proteasome (prosome, macropain) subunit, beta type, 8 | 2.54736 |
| BYSL | bystin-like | 2.53648 |
| RRAGA | Ras-related GTP binding A | 2.5222 |
| ZW10 | zw10 kinetochore protein | 2.51939 |
| HGS | hepatocyte growth factor-regulated tyrosine kinase substrate | 2.50702 |
| HSPA1A | heat shock 70kDa protein 1A | 2.48248 |
| BAMBI | BMP and activin membrane-bound inhibitor | 2.47625 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 2.44927 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 2.41365 |
| RSU1 | Ras suppressor protein 1 | 2.40239 |
| CCP110 | centriolar coiled coil protein 110kDa | 2.40235 |
| MINDY1 | MINDY lysine 48 deubiquitinase 1 | 2.40041 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | 2.39286 |
| NSMAF | neutral sphingomyelinase (N-SMase) activation associated factor | 2.37484 |
| CDC42BPB | CDC42 binding protein kinase beta (DMPK-like) | 2.36402 |
| TRIM16 | tripartite motif containing 16 | 2.34921 |
| GPC1 | glypican 1 | 2.33821 |
| ATG3 | autophagy related 3 | 2.33166 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 2.32867 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | 2.3262 |
| ACOT9 | acyl-CoA thioesterase 9 | 2.32274 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | 2.31165 |
| RALB | v-ral simian leukemia viral oncogene homolog B | 2.31048 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 2.29902 |
| INTS11 | integrator complex subunit 11 | 2.29086 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 2.28261 |
| FCHO1 | FCH domain only 1 | 2.26778 |
| EIF2B2 | eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa | 2.22862 |
| MMP2 | matrix metallopeptidase 2 | 2.22396 |
| MGAT4B | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B | 2.21872 |
| PPARG | peroxisome proliferator-activated receptor gamma | 2.19969 |
| RCBTB1 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 | 2.19903 |
| CORO1A | coronin, actin binding protein, 1A | 2.19321 |
| AXIN1 | axin 1 | 2.18108 |
| TENT4A | terminal nucleotidyltransferase 4A | 2.16706 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 2.15855 |
| PRKCD | protein kinase C, delta | 2.15065 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 2.12272 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 2.1201 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 2.09905 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 2.09118 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 2.06922 |
| CYTH1 | cytohesin 1 | 2.04642 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 2.04446 |
| CYP4F11 | cytochrome P450, family 4, subfamily F, polypeptide 11 | 2.04419 |
| BCR | breakpoint cluster region | 2.04158 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 2.03345 |
| CYCS | cytochrome c, somatic | 2.02584 |
| AP1B1 | adaptor-related protein complex 1, beta 1 subunit | 2.02173 |
| UBE2A | ubiquitin-conjugating enzyme E2A | 2.01293 |
| CENPB | centromere protein B, 80kDa | 2.00647 |
| BDNF | brain-derived neurotrophic factor | 2.00334 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -7.7599 |
| DNM1L | dynamin 1-like | -6.76598 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -5.91384 |
| GNAS | GNAS complex locus | -5.76742 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -5.73708 |
| CCNB2 | cyclin B2 | -5.29668 |
| CDK1 | cyclin-dependent kinase 1 | -5.08568 |
| ZNF586 | zinc finger protein 586 | -4.97704 |
| SLC35F2 | solute carrier family 35, member F2 | -4.43912 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -4.33477 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | -4.12694 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -4.11434 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -4.10209 |
| NIPSNAP1 | nipsnap homolog 1 (C. elegans) | -4.04012 |
| ALDOC | aldolase C, fructose-bisphosphate | -4.02164 |
| MELK | maternal embryonic leucine zipper kinase | -4.00673 |
| CDC20 | cell division cycle 20 | -3.90999 |
| CCNA2 | cyclin A2 | -3.80681 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -3.80637 |
| COPS7A | COP9 signalosome subunit 7A | -3.79769 |
| AURKB | aurora kinase B | -3.76836 |
| YKT6 | YKT6 v-SNARE homolog (S. cerevisiae) | -3.72212 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -3.68712 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -3.6832 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -3.58111 |
| HMGA2 | high mobility group AT-hook 2 | -3.49646 |
| NGRN | neugrin, neurite outgrowth associated | -3.45579 |
| PLK1 | polo-like kinase 1 | -3.37981 |
| GLOD4 | glyoxalase domain containing 4 | -3.37182 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -3.33792 |
| ADI1 | acireductone dioxygenase 1 | -3.30171 |
| RNF167 | ring finger protein 167 | -3.1954 |
| POLR1A | polymerase (RNA) I polypeptide A, 194kDa | -3.19325 |
| STMN1 | stathmin 1 | -3.04652 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | -3.02952 |
| PGM1 | phosphoglucomutase 1 | -3.01594 |
| NUP85 | nucleoporin 85kDa | -2.9113 |
| TCEAL4 | transcription elongation factor A (SII)-like 4 | -2.86712 |
| ISOC1 | isochorismatase domain containing 1 | -2.8471 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -2.84093 |
| KDM3A | lysine (K)-specific demethylase 3A | -2.83484 |
| TSEN2 | TSEN2 tRNA splicing endonuclease subunit | -2.82719 |
| MED21 | mediator complex subunit 21 | -2.79873 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -2.79538 |
| PROS1 | protein S (alpha) | -2.78606 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.77025 |
| ZNF274 | zinc finger protein 274 | -2.74497 |
| CAPRIN2 | caprin family member 2 | -2.74388 |
| TLR4 | toll-like receptor 4 | -2.693 |
| TRIB3 | tribbles pseudokinase 3 | -2.66971 |
| E2F5 | E2F transcription factor 5, p130-binding | -2.64697 |
| B4GAT1 | beta-1,4-glucuronyltransferase 1 | -2.64318 |
| TLCD3A | TLC domain containing 3A | -2.64074 |
| SLC25A13 | solute carrier family 25 (aspartate/glutamate carrier), member 13 | -2.63881 |
| HAT1 | histone acetyltransferase 1 | -2.61864 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.60444 |
| CENPE | centromere protein E, 312kDa | -2.59769 |
| ICAM3 | intercellular adhesion molecule 3 | -2.5372 |
| BIRC5 | baculoviral IAP repeat containing 5 | -2.49838 |
| FCHSD2 | FCH and double SH3 domains 2 | -2.48573 |
| RPA3 | replication protein A3, 14kDa | -2.48287 |
| FGFR4 | fibroblast growth factor receptor 4 | -2.47772 |
| SERPINA7 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 | -2.44483 |
| TRAP1 | TNF receptor-associated protein 1 | -2.43458 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -2.43191 |
| COG7 | component of oligomeric golgi complex 7 | -2.41775 |
| DERA | deoxyribose-phosphate aldolase (putative) | -2.41705 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -2.40407 |
| ZNF43 | zinc finger protein 43 | -2.39528 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -2.37928 |
| KNTC1 | kinetochore associated 1 | -2.37842 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -2.3678 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | -2.34598 |
| C2CD5 | C2 calcium-dependent domain containing 5 | -2.34059 |
| LSM6 | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.33196 |
| YARS2 | tyrosyl-tRNA synthetase 2, mitochondrial | -2.32868 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | -2.32853 |
| ZNF813 | zinc finger protein 813 | -2.29044 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | -2.28703 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | -2.28212 |
| EGR1 | early growth response 1 | -2.25951 |
| MRPS16 | mitochondrial ribosomal protein S16 | -2.2567 |
| AMDHD2 | amidohydrolase domain containing 2 | -2.253 |
| PXMP2 | peroxisomal membrane protein 2, 22kDa | -2.23439 |
| ENOPH1 | enolase-phosphatase 1 | -2.2325 |
| PGAM4 | phosphoglycerate mutase family member 4 | -2.22068 |
| MYLK | myosin light chain kinase | -2.21855 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -2.20365 |
| ATP5ME | ATP synthase membrane subunit e | -2.20194 |
| MRPS2 | mitochondrial ribosomal protein S2 | -2.18435 |
| GNG5 | guanine nucleotide binding protein (G protein), gamma 5 | -2.18021 |
| ARID3A | AT rich interactive domain 3A (BRIGHT-like) | -2.17588 |
| TCTN1 | tectonic family member 1 | -2.16645 |
| SESN1 | sestrin 1 | -2.16285 |
| POP5 | processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) | -2.15997 |
| OSGEPL1 | O-sialoglycoprotein endopeptidase-like 1 | -2.15966 |
| KIF14 | kinesin family member 14 | -2.15883 |
| TMEM258 | transmembrane protein 258 | -2.1533 |
| PIM2 | Pim-2 proto-oncogene, serine/threonine kinase | -2.14676 |
| RPIA | ribose 5-phosphate isomerase A | -2.12783 |
| TUBA3E | tubulin, alpha 3e | -2.10116 |
| SNRPF | small nuclear ribonucleoprotein polypeptide F | -2.09882 |
| PSMG1 | proteasome (prosome, macropain) assembly chaperone 1 | -2.08197 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -2.08196 |
| TIMM23 | translocase of inner mitochondrial membrane 23 homolog (yeast) | -2.08191 |
| ZNF528 | zinc finger protein 528 | -2.07247 |
| LOC122539214 | Zinc finger protein LOC122539214 | -2.06838 |
| IL24 | interleukin 24 | -2.06304 |
| ATP6V0B | ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b | -2.06275 |
| ZNF573 | zinc finger protein 573 | -2.06216 |
| CCNF | cyclin F | -2.05924 |
| CHEK2 | checkpoint kinase 2 | -2.0582 |
| ZNF761 | zinc finger protein 761 | -2.05818 |
| PEG10 | paternally expressed 10 | -2.05333 |
| CDK4 | cyclin-dependent kinase 4 | -2.04636 |
| CCNH | cyclin H | -2.04542 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -2.04221 |
| CCDC85B | coiled-coil domain containing 85B | -2.0394 |
| MMD | monocyte to macrophage differentiation-associated | -2.02861 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | -2.02233 |
| EMC6 | ER membrane protein complex subunit 6 | -2.00206 |
