CRCGN009_HEPG2_24H:F02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description potassium 1h-indol-3-yl sulfate 10.85 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

124 genes differentially expressed following the CRCGN009_HEPG2_24H:F02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 8.18561
SQOR sulfide quinone oxidoreductase 6.27915
BACE2 beta-site APP-cleaving enzyme 2 6.20199
VAT1 vesicle amine transport 1 6.16264
MVP major vault protein 5.54222
CBR3 carbonyl reductase 3 5.22718
UGDH UDP-glucose 6-dehydrogenase 5.13549
ABHD4 abhydrolase domain containing 4 4.89877
RAP1GAP RAP1 GTPase activating protein 4.87792
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.74221
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 4.15535
ANO1 anoctamin 1, calcium activated chloride channel 4.01513
CEMIP2 cell migration inducing hyaluronidase 2 4.01026
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.61405
HMOX1 heme oxygenase 1 3.59999
SOCS2 suppressor of cytokine signaling 2 3.55524
E2F2 E2F transcription factor 2 3.51674
ZFP36 ZFP36 ring finger protein 3.46334
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.30268
CTSL cathepsin L 3.23615
RPL39L ribosomal protein L39-like 3.23577
AXIN1 axin 1 3.16013
CHMP6 charged multivesicular body protein 6 3.12501
STX4 syntaxin 4 3.11861
LCN2 lipocalin 2 3.07029
BMP4 bone morphogenetic protein 4 3.0187
UBQLN2 ubiquilin 2 2.9856
RPP38 ribonuclease P/MRP 38kDa subunit 2.98541
RB1 retinoblastoma 1 2.95762
KDM5A lysine (K)-specific demethylase 5A 2.91126
ALAS1 5'-aminolevulinate synthase 1 2.90371
CNPY3 canopy FGF signaling regulator 3 2.86458
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.75252
STAP2 signal transducing adaptor family member 2 2.73409
GLRX glutaredoxin (thioltransferase) 2.65531
STIMATE STIM activating enhancer 2.65352
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.63887
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.63423
MINDY1 MINDY lysine 48 deubiquitinase 1 2.58983
ZKSCAN2 zinc finger with KRAB and SCAN domains 2 2.56687
MCM3 minichromosome maintenance complex component 3 2.50286
HLA-DRA major histocompatibility complex, class II, DR alpha 2.47524
ATG3 autophagy related 3 2.41948
SLC25A46 solute carrier family 25, member 46 2.41615
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 2.36397
SPDEF SAM pointed domain containing ETS transcription factor 2.35378
MAP7 microtubule-associated protein 7 2.3336
SQSTM1 sequestosome 1 2.32706
GCLC glutamate-cysteine ligase, catalytic subunit 2.31496
PCDHB11 protocadherin beta 11 2.31481
ATP11B ATPase, class VI, type 11B 2.30997
FOSL1 FOS-like antigen 1 2.30805
TMC5 transmembrane channel-like 5 2.29665
GSR glutathione reductase 2.28898
CRYZ crystallin, zeta (quinone reductase) 2.2474
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.24718
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.2275
EGF epidermal growth factor 2.21874
TAC4 tachykinin 4 (hemokinin) 2.15782
NPDC1 neural proliferation, differentiation and control, 1 2.10553
PPARG peroxisome proliferator-activated receptor gamma 2.10082
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.09472
RSU1 Ras suppressor protein 1 2.08602
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.0682
DHRS3 dehydrogenase/reductase (SDR family) member 3 2.04955
CCDC86 coiled-coil domain containing 86 2.04353
ACOT9 acyl-CoA thioesterase 9 2.0334
PTK2 protein tyrosine kinase 2 2.0279
UFM1 ubiquitin-fold modifier 1 2.02622
PFDN1 prefoldin subunit 1 2.00303

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.94949
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.48704
TLCD3A TLC domain containing 3A -5.86959
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -5.44539
CCNB2 cyclin B2 -5.35392
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.25446
CDC20 cell division cycle 20 -4.86431
TCTN1 tectonic family member 1 -4.32507
PSRC1 proline/serine-rich coiled-coil 1 -4.08015
GLOD4 glyoxalase domain containing 4 -3.69509
FGFR4 fibroblast growth factor receptor 4 -3.66891
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.63982
CDK1 cyclin-dependent kinase 1 -3.50954
LDHD lactate dehydrogenase D -3.33559
SLC35F2 solute carrier family 35, member F2 -3.22351
ADI1 acireductone dioxygenase 1 -3.21558
ISOC1 isochorismatase domain containing 1 -3.13526
AURKB aurora kinase B -3.07128
PCNA proliferating cell nuclear antigen -3.06594
TRIB3 tribbles pseudokinase 3 -2.94232
EIF5 eukaryotic translation initiation factor 5 -2.84381
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.84238
UBE2C ubiquitin-conjugating enzyme E2C -2.8316
SPAG4 sperm associated antigen 4 -2.7973
SNX11 sorting nexin 11 -2.68528
CCNA2 cyclin A2 -2.68384
TMEM97 transmembrane protein 97 -2.66036
HMGA2 high mobility group AT-hook 2 -2.61352
PECR peroxisomal trans-2-enoyl-CoA reductase -2.5974
ICAM3 intercellular adhesion molecule 3 -2.56229
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.50567
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.4757
ZMIZ1 zinc finger, MIZ-type containing 1 -2.43522
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.42746
CSK c-src tyrosine kinase -2.42542
NGRN neugrin, neurite outgrowth associated -2.40257
CRELD2 cysteine-rich with EGF-like domains 2 -2.37784
FBXL12 F-box and leucine-rich repeat protein 12 -2.36395
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.34242
STMN1 stathmin 1 -2.28127
GNAS GNAS complex locus -2.23316
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.22895
ALDOC aldolase C, fructose-bisphosphate -2.22554
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.22485
CTSD cathepsin D -2.22028
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.20361
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.16755
CENPE centromere protein E, 312kDa -2.15706
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.13947
RPS4Y1 ribosomal protein S4, Y-linked 1 -2.11621
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 -2.11531
TXNDC9 thioredoxin domain containing 9 -2.07118
EGR1 early growth response 1 -2.05087
CCNH cyclin H -2.03004