| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | potassium 1h-indol-3-yl sulfate 1.36 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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184 genes differentially expressed following the CRCGN009_HEPG2_24H:F05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CNPY3 | canopy FGF signaling regulator 3 | 5.95777 |
| ST3GAL5 | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | 5.87525 |
| PACSIN3 | protein kinase C and casein kinase substrate in neurons 3 | 5.74216 |
| VAT1 | vesicle amine transport 1 | 5.45963 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 5.45063 |
| ADRB2 | adrenoceptor beta 2, surface | 5.28438 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 5.0148 |
| LCN2 | lipocalin 2 | 4.91095 |
| CYCS | cytochrome c, somatic | 4.86768 |
| MVP | major vault protein | 4.66285 |
| LSR | lipolysis stimulated lipoprotein receptor | 4.627 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 4.54279 |
| CCNF | cyclin F | 4.54195 |
| ZFP36 | ZFP36 ring finger protein | 4.48639 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 4.39071 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 4.02287 |
| EPN2 | epsin 2 | 3.68704 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | 3.67931 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 3.5529 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 3.53246 |
| AMDHD2 | amidohydrolase domain containing 2 | 3.39944 |
| VAV3 | vav 3 guanine nucleotide exchange factor | 3.38122 |
| PRR15L | proline rich 15-like | 3.15507 |
| CCNA1 | cyclin A1 | 3.15268 |
| SQOR | sulfide quinone oxidoreductase | 3.12026 |
| MMP15 | matrix metallopeptidase 15 (membrane-inserted) | 3.05184 |
| MCM3 | minichromosome maintenance complex component 3 | 3.01303 |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | 2.99143 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 2.94032 |
| TG | thyroglobulin | 2.93449 |
| TPO | thyroid peroxidase | 2.88646 |
| SLC25A24 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 | 2.84713 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 2.75137 |
| CXCR4 | chemokine (C-X-C motif) receptor 4 | 2.73514 |
| ETV1 | ets variant 1 | 2.61663 |
| MINDY1 | MINDY lysine 48 deubiquitinase 1 | 2.54739 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 2.54581 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 2.53778 |
| CA7 | carbonic anhydrase VII | 2.53225 |
| GUCA2A | guanylate cyclase activator 2A (guanylin) | 2.52068 |
| CTR9 | CTR9, Paf1/RNA polymerase II complex component | 2.50402 |
| GTPBP8 | GTP-binding protein 8 (putative) | 2.45292 |
| DRP2 | dystrophin related protein 2 | 2.40815 |
| CITED1 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 | 2.3587 |
| CORO2A | coronin, actin binding protein, 2A | 2.35668 |
| NOS1AP | nitric oxide synthase 1 (neuronal) adaptor protein | 2.35636 |
| SPDEF | SAM pointed domain containing ETS transcription factor | 2.34226 |
| TOPBP1 | topoisomerase (DNA) II binding protein 1 | 2.28868 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 2.27562 |
| CTSL | cathepsin L | 2.27432 |
| SYK | spleen tyrosine kinase | 2.26736 |
| ARMCX6 | armadillo repeat containing, X-linked 6 | 2.23796 |
| PEX11A | peroxisomal biogenesis factor 11 alpha | 2.23611 |
| TSHR | thyroid stimulating hormone receptor | 2.22805 |
| SLC13A4 | solute carrier family 13 (sodium/sulfate symporter), member 4 | 2.20678 |
| UGDH | UDP-glucose 6-dehydrogenase | 2.20482 |
| PRRG3 | proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane) | 2.20187 |
| STAP2 | signal transducing adaptor family member 2 | 2.19673 |
| TXNRD1 | thioredoxin reductase 1 | 2.19104 |
| MS4A12 | membrane-spanning 4-domains, subfamily A, member 12 | 2.17701 |
| DUOX2 | dual oxidase 2 | 2.1674 |
| FLRT1 | fibronectin leucine rich transmembrane protein 1 | 2.1517 |
| FAM32A | family with sequence similarity 32, member A | 2.14812 |
| PRKCQ | protein kinase C, theta | 2.1436 |
| EFNA3 | ephrin-A3 | 2.14258 |
| TMEM109 | transmembrane protein 109 | 2.13426 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 2.13367 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | 2.12741 |
| CCL5 | chemokine (C-C motif) ligand 5 | 2.12679 |
| PARM1 | prostate androgen-regulated mucin-like protein 1 | 2.12653 |
| VWA5A | von Willebrand factor A domain containing 5A | 2.11202 |
| STARD5 | StAR-related lipid transfer (START) domain containing 5 | 2.09043 |
| RALGDS | ral guanine nucleotide dissociation stimulator | 2.08371 |
| AQP8 | aquaporin 8 | 2.0677 |
| CRYZ | crystallin, zeta (quinone reductase) | 2.06563 |
| SEMA6B | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B | 2.06551 |
| PCSK7 | proprotein convertase subtilisin/kexin type 7 | 2.05794 |
| CD177 | CD177 molecule | 2.05558 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 2.0341 |
| GDF10 | growth differentiation factor 10 | 2.03167 |
| CA6 | carbonic anhydrase VI | 2.02878 |
| GDPD2 | glycerophosphodiester phosphodiesterase domain containing 2 | 2.02529 |
| ACVRL1 | activin A receptor type II-like 1 | 2.02445 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 2.02333 |
| CEACAM7 | carcinoembryonic antigen-related cell adhesion molecule 7 | 2.02301 |
| TERT | telomerase reverse transcriptase | 2.02218 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 2.00128 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -10.0 |
| ZNF586 | zinc finger protein 586 | -8.80296 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -7.13004 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | -6.7586 |
| CHMP4B | charged multivesicular body protein 4B | -6.27662 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -5.86972 |
| TCTN1 | tectonic family member 1 | -5.66368 |
| SLC35F2 | solute carrier family 35, member F2 | -5.09579 |
| FASTKD5 | FAST kinase domains 5 | -4.88503 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -4.39192 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -4.34065 |
| TLR4 | toll-like receptor 4 | -4.30497 |
| CSK | c-src tyrosine kinase | -4.16666 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -3.99919 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -3.78547 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -3.75458 |
| GOLT1B | golgi transport 1B | -3.71207 |
| MRPS2 | mitochondrial ribosomal protein S2 | -3.69079 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -3.66578 |
| SPAG4 | sperm associated antigen 4 | -3.60209 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -3.57229 |
| TBCB | tubulin folding cofactor B | -3.43427 |
| ANKRD27 | ankyrin repeat domain 27 (VPS9 domain) | -3.37305 |
| TMEM147 | transmembrane protein 147 | -3.31145 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -3.27471 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | -3.25538 |
| PCNA | proliferating cell nuclear antigen | -3.21539 |
| PSMD8 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 | -3.10657 |
| CCNB1 | cyclin B1 | -3.026 |
| AURKB | aurora kinase B | -2.94985 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -2.90226 |
| ZNF146 | zinc finger protein 146 | -2.82001 |
| PEG10 | paternally expressed 10 | -2.81194 |
| FHL2 | four and a half LIM domains 2 | -2.81055 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | -2.78637 |
| EGF | epidermal growth factor | -2.78407 |
| PDZD2 | PDZ domain containing 2 | -2.78218 |
| CCNB2 | cyclin B2 | -2.76619 |
| ACAA1 | acetyl-CoA acyltransferase 1 | -2.73821 |
| CAPNS1 | calpain, small subunit 1 | -2.69006 |
| COX6B1 | cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) | -2.65991 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -2.57058 |
| GPATCH1 | G patch domain containing 1 | -2.56582 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | -2.56574 |
| SDHAF1 | succinate dehydrogenase complex assembly factor 1 | -2.51553 |
| PDCD5 | programmed cell death 5 | -2.47945 |
| ZNF426 | zinc finger protein 426 | -2.46847 |
| CYB5A | cytochrome b5 type A (microsomal) | -2.39389 |
| LIN37 | lin-37 DREAM MuvB core complex component | -2.38623 |
| RHCG | Rh family, C glycoprotein | -2.35406 |
| LDHD | lactate dehydrogenase D | -2.35304 |
| ZNF551 | zinc finger protein 551 | -2.33229 |
| CETN2 | centrin, EF-hand protein, 2 | -2.30909 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -2.27436 |
| TXLNG | taxilin gamma | -2.27365 |
| ZNF134 | zinc finger protein 134 | -2.2621 |
| PSENEN | presenilin enhancer gamma secretase subunit | -2.24997 |
| DRC3 | dynein regulatory complex subunit 3 | -2.23847 |
| TSGA10 | testis specific, 10 | -2.23596 |
| CLDN10 | claudin 10 | -2.20472 |
| PGM1 | phosphoglucomutase 1 | -2.1972 |
| DNAH7 | dynein, axonemal, heavy chain 7 | -2.19158 |
| ZNF529 | zinc finger protein 529 | -2.19106 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -2.18937 |
| MCAT | malonyl CoA:ACP acyltransferase (mitochondrial) | -2.18865 |
| NLRP2B | NLR family pyrin domain containing 2B | -2.17744 |
| MTMR12 | myotubularin related protein 12 | -2.16824 |
| ADIPOR2 | adiponectin receptor 2 | -2.16744 |
| CCDC198 | coiled-coil domain containing 198 | -2.16642 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | -2.16352 |
| POP7 | processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) | -2.13971 |
| SMIM10L1 | small integral membrane protein 10 like 1 | -2.12835 |
| ALDH8A1 | aldehyde dehydrogenase 8 family, member A1 | -2.12606 |
| RBM42 | RNA binding motif protein 42 | -2.12573 |
| ZNF761 | zinc finger protein 761 | -2.12441 |
| ERCC1 | excision repair cross-complementation group 1 | -2.12416 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -2.12291 |
| VCPKMT | valosin containing protein lysine (K) methyltransferase | -2.1229 |
| peptide deformylase (mitochondrial) | -2.07604 | |
| PER1 | period circadian clock 1 | -2.07537 |
| ZSCAN5A | zinc finger and SCAN domain containing 5A | -2.07461 |
| PRPF4 | pre-mRNA processing factor 4 | -2.07371 |
| RUVBL2 | RuvB-like AAA ATPase 2 | -2.06449 |
| RBM15 | RNA binding motif protein 15 | -2.05799 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | -2.05327 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | -2.05025 |
| KL | klotho | -2.04458 |
| EXOSC5 | exosome component 5 | -2.04105 |
| NDUFV1 | NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa | -2.03373 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | -2.02585 |
| HAPSTR1 | HUWE1 associated protein modifying stress responses | -2.02146 |
| ZNF184 | zinc finger protein 184 | -2.01896 |
| VDAC1 | voltage-dependent anion channel 1 | -2.01464 |
| ZNF302 | zinc finger protein 302 | -2.01091 |
| H1-0 | H1.0 linker histone | -2.01068 |
| TMPRSS11E | transmembrane protease, serine 11E | -2.00884 |
| ZNF304 | zinc finger protein 304 | -2.00006 |
