CRCGN009_HEPG2_24H:F10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

57 genes differentially expressed following the CRCGN009_HEPG2_24H:F10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 8.71741
MAP7 microtubule-associated protein 7 6.60721
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.87859
CARMIL1 capping protein regulator and myosin 1 linker 1 4.85102
LAGE3 L antigen family, member 3 4.80898
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.69902
BZW2 basic leucine zipper and W2 domains 2 4.62602
DYNLT3 dynein, light chain, Tctex-type 3 4.62368
STK10 serine/threonine kinase 10 4.59233
ATP11B ATPase, class VI, type 11B 4.36887
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.36544
STIMATE STIM activating enhancer 4.26144
ADRB2 adrenoceptor beta 2, surface 4.24145
C2CD2 C2 calcium-dependent domain containing 2 4.21832
AMDHD2 amidohydrolase domain containing 2 4.19554
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.55064
CCL2 chemokine (C-C motif) ligand 2 3.25814
NFIL3 nuclear factor, interleukin 3 regulated 3.25634
TIAM1 T-cell lymphoma invasion and metastasis 1 3.17987
BLMH bleomycin hydrolase 3.083
PFKL phosphofructokinase, liver 3.00607
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.99419
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.97241
TPD52L2 tumor protein D52-like 2 2.65255
JADE2 jade family PHD finger 2 2.59372
KIF20A kinesin family member 20A 2.50975
RXYLT1 ribitol xylosyltransferase 1 2.46714
CCNF cyclin F 2.34362
GPER1 G protein-coupled estrogen receptor 1 2.3333
CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 2.16627
CALML5 calmodulin-like 5 2.15791
UBXN8 UBX domain protein 8 2.14419
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.08808
GSTZ1 glutathione S-transferase zeta 1 2.05551
MTG1 mitochondrial ribosome-associated GTPase 1 2.04379
ZFP36 ZFP36 ring finger protein 2.0005

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -6.62899
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -5.31293
LDHD lactate dehydrogenase D -5.3065
VAT1 vesicle amine transport 1 -4.78787
CD320 CD320 molecule -4.55314
MRPS2 mitochondrial ribosomal protein S2 -4.5224
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.51504
PCNA proliferating cell nuclear antigen -4.10528
KDM3A lysine (K)-specific demethylase 3A -3.81939
THAP11 THAP domain containing 11 -3.72437
SLC35F2 solute carrier family 35, member F2 -3.59527
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.56624
LOC124907782 dual specificity protein phosphatase 22 -3.31696
CAB39 calcium binding protein 39 -3.05399
DERA deoxyribose-phosphate aldolase (putative) -3.04154
OXA1L oxidase (cytochrome c) assembly 1-like -3.02108
SNX11 sorting nexin 11 -2.97796
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.93694
PTPRK protein tyrosine phosphatase, receptor type, K -2.5994
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.18854
RAI14 retinoic acid induced 14 -2.0407