CRCGN009_HEPG2_24H:F12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

67 genes differentially expressed following the CRCGN009_HEPG2_24H:F12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 4.97799
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 4.97165
EPHB2 EPH receptor B2 4.76715
CCDC92 coiled-coil domain containing 92 4.75042
LCN2 lipocalin 2 4.68697
SATB1 SATB homeobox 1 4.66111
RAB11FIP1 RAB11 family interacting protein 1 (class I) 4.60622
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.56933
CHMP6 charged multivesicular body protein 6 4.07975
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 4.07143
MNAT1 MNAT CDK-activating kinase assembly factor 1 3.95405
E2F2 E2F transcription factor 2 3.93322
KIFBP kinesin family binding protein 3.89987
HLA-DRA major histocompatibility complex, class II, DR alpha 3.43202
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.32272
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.30441
CDPF1 cysteine-rich, DPF motif domain containing 1 3.25232
ICAM1 intercellular adhesion molecule 1 3.22786
FPGS folylpolyglutamate synthase 2.93589
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.88747
MAP7 microtubule-associated protein 7 2.758
CCNF cyclin F 2.71161
JADE2 jade family PHD finger 2 2.66521
LPAR2 lysophosphatidic acid receptor 2 2.5262
GDF2 growth differentiation factor 2 2.50909
GATA2 GATA binding protein 2 2.4933
GPER1 G protein-coupled estrogen receptor 1 2.48788
SNAP25 synaptosomal-associated protein, 25kDa 2.44264
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.42519
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.42497
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 2.39979
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.37666
KIF20A kinesin family member 20A 2.30852
SIX1 SIX homeobox 1 2.29368
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 2.22221
WNT4 wingless-type MMTV integration site family, member 4 2.1594
MATN4 matrilin 4 2.15039
TBP TATA box binding protein 2.13571
RAB21 RAB21, member RAS oncogene family 2.1264
ACTG2 actin, gamma 2, smooth muscle, enteric 2.0641
MYOD1 myogenic differentiation 1 2.05663
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.04766
TNP1 transition protein 1 (during histone to protamine replacement) 2.02577
RNASE12 ribonuclease, RNase A family, 12 (non-active) 2.02412
TREH trehalase (brush-border membrane glycoprotein) 2.00898

decreased expression

Symbol Name Standardized Value
TLR4 toll-like receptor 4 -6.9212
CDC25B cell division cycle 25B -5.7988
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -5.25541
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.13788
PCNA proliferating cell nuclear antigen -5.07529
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.67491
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.53059
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -4.3852
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.15293
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.71279
SLC35F2 solute carrier family 35, member F2 -3.20153
LOC124907782 dual specificity protein phosphatase 22 -2.82789
TXNDC9 thioredoxin domain containing 9 -2.79215
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.7313
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.68649
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.5638
TLCD3A TLC domain containing 3A -2.55428
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.54439
STAMBP STAM binding protein -2.45608
ZW10 zw10 kinetochore protein -2.29711
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) -2.08725
OXA1L oxidase (cytochrome c) assembly 1-like -2.01547