CRCGN009_HEPG2_24H:F13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tolazamide 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

70 genes differentially expressed following the CRCGN009_HEPG2_24H:F13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STK10 serine/threonine kinase 10 9.2366
ADRB2 adrenoceptor beta 2, surface 9.11297
GPATCH8 G patch domain containing 8 5.31304
STIMATE STIM activating enhancer 5.16276
ANO1 anoctamin 1, calcium activated chloride channel 4.8408
EPHA3 EPH receptor A3 4.70589
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.70286
HLA-DMA major histocompatibility complex, class II, DM alpha 4.6503
RPP38 ribonuclease P/MRP 38kDa subunit 4.41456
MELK maternal embryonic leucine zipper kinase 4.34904
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.01804
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.77042
GATA3 GATA binding protein 3 3.49208
VGLL4 vestigial-like family member 4 3.10158
GATA2 GATA binding protein 2 3.06855
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.05812
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.99166
CEMIP2 cell migration inducing hyaluronidase 2 2.86342
PLSCR3 phospholipid scramblase 3 2.65864
GPER1 G protein-coupled estrogen receptor 1 2.63599
JADE2 jade family PHD finger 2 2.59976
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.58703
TIAM1 T-cell lymphoma invasion and metastasis 1 2.5574
NUP133 nucleoporin 133kDa 2.47405
EGF epidermal growth factor 2.46161
ZNF589 zinc finger protein 589 2.43031
MIA melanoma inhibitory activity 2.26771
GABRP gamma-aminobutyric acid (GABA) A receptor, pi 2.25511
SFRP1 secreted frizzled-related protein 1 2.20062
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.18761
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28 2.17387
DIPK1A divergent protein kinase domain 1A 2.16894
HNRNPCL1 heterogeneous nuclear ribonucleoprotein C-like 1 2.1652
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase 2.15188
MAGEC2 melanoma antigen family C2 2.14259
MAGEA4 melanoma antigen family A4 2.13102
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.10779
CHEK2 checkpoint kinase 2 2.10023
RNF38 ring finger protein 38 2.09128
MAGEA10 melanoma antigen family A10 2.08713
TSKU tsukushi, small leucine rich proteoglycan 2.06257
CRABP1 cellular retinoic acid binding protein 1 2.05633
WBP11 WW domain binding protein 11 2.00187

decreased expression

Symbol Name Standardized Value
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -9.26832
CASP7 caspase 7, apoptosis-related cysteine peptidase -7.17357
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -6.72496
NUP93 nucleoporin 93kDa -5.92433
LDHD lactate dehydrogenase D -5.06769
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.62263
VAT1 vesicle amine transport 1 -4.59887
CCNB2 cyclin B2 -4.57375
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.2584
NT5DC2 5'-nucleotidase domain containing 2 -3.98622
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.85905
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.82546
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.21098
ZNF586 zinc finger protein 586 -3.00195
MAPK13 mitogen-activated protein kinase 13 -2.78642
RBM15B RNA binding motif protein 15B -2.73427
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.69128
DCK deoxycytidine kinase -2.67857
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.59397
GIPC1 GIPC PDZ domain containing family, member 1 -2.49855
TLCD3A TLC domain containing 3A -2.48134
SELENOW selenoprotein W -2.33876
MYL5 myosin, light chain 5, regulatory -2.31344
SMYD3 SET and MYND domain containing 3 -2.2373
DOHH deoxyhypusine hydroxylase/monooxygenase -2.15482
RFK riboflavin kinase -2.04264
CCDC51 coiled-coil domain containing 51 -2.00349