| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | tolazamide 20.0 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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72 genes differentially expressed following the CRCGN009_HEPG2_24H:F14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GATA3 | GATA binding protein 3 | 6.4751 |
| LCN2 | lipocalin 2 | 6.00521 |
| GPATCH8 | G patch domain containing 8 | 5.64133 |
| NOTCH1 | notch 1 | 5.13093 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 4.90731 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 4.86442 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 4.52082 |
| PNKP | polynucleotide kinase 3'-phosphatase | 4.45681 |
| EPHB2 | EPH receptor B2 | 4.41112 |
| DIPK1A | divergent protein kinase domain 1A | 3.8579 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 3.42639 |
| GPER1 | G protein-coupled estrogen receptor 1 | 3.26599 |
| ABHD6 | abhydrolase domain containing 6 | 3.20089 |
| MAP7 | microtubule-associated protein 7 | 3.13896 |
| BAMBI | BMP and activin membrane-bound inhibitor | 3.06201 |
| KIFBP | kinesin family binding protein | 2.89742 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 2.8955 |
| BIRC2 | baculoviral IAP repeat containing 2 | 2.66865 |
| NOSIP | nitric oxide synthase interacting protein | 2.62224 |
| PPIC | peptidylprolyl isomerase C (cyclophilin C) | 2.46122 |
| GDPD5 | glycerophosphodiester phosphodiesterase domain containing 5 | 2.36957 |
| CHN1 | chimerin 1 | 2.3233 |
| PUM1 | pumilio RNA-binding family member 1 | 2.2778 |
| RAB3A | RAB3A, member RAS oncogene family | 2.25131 |
| MACROD1 | MACRO domain containing 1 | 2.21048 |
| GDF7 | growth differentiation factor 7 | 2.21025 |
| SLC39A6 | solute carrier family 39 (zinc transporter), member 6 | 2.19283 |
| ALKBH1 | alkB, alkylation repair homolog 1 (E. coli) | 2.15653 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 2.15197 |
| TBC1D12 | TBC1 domain family, member 12 | 2.09656 |
| CISH | cytokine inducible SH2-containing protein | 2.08126 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 2.04884 |
| CCNL2 | cyclin L2 | 2.0465 |
| PEX6 | peroxisomal biogenesis factor 6 | 2.02753 |
| SMAD3 | SMAD family member 3 | 2.02223 |
| DTD1 | D-tyrosyl-tRNA deacylase 1 | 2.00917 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GTPBP8 | GTP-binding protein 8 (putative) | -9.06095 |
| NUP93 | nucleoporin 93kDa | -4.93541 |
| NRIP1 | nuclear receptor interacting protein 1 | -4.92956 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -4.9225 |
| CCNB1 | cyclin B1 | -4.80746 |
| FASTKD5 | FAST kinase domains 5 | -4.71672 |
| PEG10 | paternally expressed 10 | -4.64792 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -4.52876 |
| MAPK13 | mitogen-activated protein kinase 13 | -4.1973 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -3.98768 |
| PCNA | proliferating cell nuclear antigen | -3.98311 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -3.90861 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -3.75004 |
| CD58 | CD58 molecule | -3.68709 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -3.65643 |
| GNAS | GNAS complex locus | -3.37173 |
| YME1L1 | YME1-like 1 ATPase | -3.30525 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -3.29207 |
| TLR4 | toll-like receptor 4 | -2.95602 |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | -2.95056 |
| EIF5 | eukaryotic translation initiation factor 5 | -2.71861 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -2.59531 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | -2.54689 |
| GPN1 | GPN-loop GTPase 1 | -2.37544 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -2.28583 |
| PTPN4 | protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) | -2.13372 |
| CSK | c-src tyrosine kinase | -2.11697 |
| ERP29 | endoplasmic reticulum protein 29 | -2.11282 |
| HSD17B10 | hydroxysteroid (17-beta) dehydrogenase 10 | -2.10662 |
| CCNH | cyclin H | -2.102 |
| PTH2R | parathyroid hormone 2 receptor | -2.07451 |
| F8 | coagulation factor VIII, procoagulant component | -2.06792 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | -2.05027 |
| LPIN2 | lipin 2 | -2.04751 |
| PPP1R9A | protein phosphatase 1, regulatory subunit 9A | -2.04336 |
| PLA2G15 | phospholipase A2, group XV | -2.03169 |
