| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | tolazamide 10.0 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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82 genes differentially expressed following the CRCGN009_HEPG2_24H:F15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| UBQLN2 | ubiquilin 2 | 8.78399 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 6.13748 |
| CCNF | cyclin F | 5.08551 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 5.03715 |
| BTK | Bruton agammaglobulinemia tyrosine kinase | 4.6524 |
| SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | 4.59192 |
| ADRB2 | adrenoceptor beta 2, surface | 4.42101 |
| IL1B | interleukin 1, beta | 4.20052 |
| MAMLD1 | mastermind-like domain containing 1 | 4.16802 |
| LSR | lipolysis stimulated lipoprotein receptor | 4.11507 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 4.04707 |
| STIMATE | STIM activating enhancer | 4.04548 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 3.92376 |
| ABHD6 | abhydrolase domain containing 6 | 3.82142 |
| EPN2 | epsin 2 | 3.40549 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 3.33737 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 3.31694 |
| MEST | mesoderm specific transcript | 3.31312 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 3.20249 |
| PRR15L | proline rich 15-like | 3.13074 |
| TRIM13 | tripartite motif containing 13 | 2.96474 |
| MAP7 | microtubule-associated protein 7 | 2.82943 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | 2.78323 |
| JADE2 | jade family PHD finger 2 | 2.58958 |
| TRIM21 | tripartite motif containing 21 | 2.50923 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 2.40146 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 2.3912 |
| TLR2 | toll-like receptor 2 | 2.30411 |
| PPBP | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) | 2.24366 |
| FPGT | fucose-1-phosphate guanylyltransferase | 2.21757 |
| TAF5 | TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa | 2.21031 |
| APOC3 | apolipoprotein C-III | 2.18237 |
| BCL11A | B-cell CLL/lymphoma 11A (zinc finger protein) | 2.1791 |
| NR2C2 | nuclear receptor subfamily 2, group C, member 2 | 2.15922 |
| IFIT5 | interferon-induced protein with tetratricopeptide repeats 5 | 2.12834 |
| XAF1 | XIAP associated factor 1 | 2.09423 |
| DMAP1 | DNA methyltransferase 1 associated protein 1 | 2.08176 |
| ARHGEF9 | Cdc42 guanine nucleotide exchange factor (GEF) 9 | 2.06988 |
| TFEC | transcription factor EC | 2.04847 |
| CTSL | cathepsin L | 2.0457 |
| ATP11B | ATPase, class VI, type 11B | 2.0449 |
| CDK14 | cyclin-dependent kinase 14 | 2.04306 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PCNA | proliferating cell nuclear antigen | -9.75746 |
| ADI1 | acireductone dioxygenase 1 | -7.46584 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | -5.84352 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -5.83844 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | -5.20808 |
| VAT1 | vesicle amine transport 1 | -5.08119 |
| DSG2 | desmoglein 2 | -4.80561 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -4.48588 |
| PEG10 | paternally expressed 10 | -4.36498 |
| LDHD | lactate dehydrogenase D | -4.26181 |
| SLC25A13 | solute carrier family 25 (aspartate/glutamate carrier), member 13 | -4.15105 |
| CCNB1 | cyclin B1 | -4.10018 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -4.04746 |
| CHMP4B | charged multivesicular body protein 4B | -3.95666 |
| FAIM | Fas apoptotic inhibitory molecule | -3.8569 |
| CSK | c-src tyrosine kinase | -3.7623 |
| YME1L1 | YME1-like 1 ATPase | -3.53591 |
| GNAS | GNAS complex locus | -3.43523 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | -3.40732 |
| VDAC1 | voltage-dependent anion channel 1 | -3.09419 |
| APIP | APAF1 interacting protein | -2.73002 |
| BDH1 | 3-hydroxybutyrate dehydrogenase, type 1 | -2.71574 |
| SQSTM1 | sequestosome 1 | -2.67331 |
| EIF5 | eukaryotic translation initiation factor 5 | -2.44491 |
| CHEK1 | checkpoint kinase 1 | -2.44182 |
| CLTB | clathrin, light chain B | -2.36585 |
| EGF | epidermal growth factor | -2.35797 |
| RAI14 | retinoic acid induced 14 | -2.35429 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -2.26996 |
| PDHX | pyruvate dehydrogenase complex, component X | -2.25814 |
| EXD2 | exonuclease 3'-5' domain containing 2 | -2.24352 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | -2.199 |
| MATCAP2 | microtubule associated tyrosine carboxypeptidase 2 | -2.16872 |
| EIF2B2 | eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa | -2.14755 |
| ZW10 | zw10 kinetochore protein | -2.12377 |
| LGMN | legumain | -2.11466 |
| EDEM1 | ER degradation enhancer, mannosidase alpha-like 1 | -2.11408 |
| WASHC4 | WASH complex subunit 4 | -2.06016 |
| MSANTD3-TMEFF1 | MSANTD3-TMEFF1 readthrough | -2.03782 |
| MED4 | mediator complex subunit 4 | -2.02788 |
