CRCGN009_HEPG2_24H:F17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tolazamide 2.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

47 genes differentially expressed following the CRCGN009_HEPG2_24H:F17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 7.95119
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.75787
TAC4 tachykinin 4 (hemokinin) 4.73777
UBQLN2 ubiquilin 2 4.3912
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 4.3867
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.32712
CBR3 carbonyl reductase 3 4.27103
STIMATE STIM activating enhancer 4.11012
BACE2 beta-site APP-cleaving enzyme 2 4.09091
C2CD2 C2 calcium-dependent domain containing 2 3.91342
LCN2 lipocalin 2 3.64641
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.48356
MAMLD1 mastermind-like domain containing 1 3.20566
CIAO3 cytosolic iron-sulfur assembly component 3 3.04257
SNAP25 synaptosomal-associated protein, 25kDa 2.77317
LPAR2 lysophosphatidic acid receptor 2 2.64086
RRAGA Ras-related GTP binding A 2.58455
FZD7 frizzled class receptor 7 2.48618
CYCS cytochrome c, somatic 2.48025
MAP7 microtubule-associated protein 7 2.32931
UFM1 ubiquitin-fold modifier 1 2.30738
PCDHB11 protocadherin beta 11 2.30562
GATA3 GATA binding protein 3 2.27604
RXYLT1 ribitol xylosyltransferase 1 2.27315
CMC2 C-x(9)-C motif containing 2 2.25925
EVL Enah/Vasp-like 2.24498
TIAM1 T-cell lymphoma invasion and metastasis 1 2.07088

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -8.25742
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.96916
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -5.64079
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.36314
RAI14 retinoic acid induced 14 -4.37551
VAT1 vesicle amine transport 1 -4.2152
CTSD cathepsin D -4.15886
CSK c-src tyrosine kinase -4.10345
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.96234
NGRN neugrin, neurite outgrowth associated -2.55475
OXA1L oxidase (cytochrome c) assembly 1-like -2.48916
RAP2A RAP2A, member of RAS oncogene family -2.44445
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -2.2201
NR1H2 nuclear receptor subfamily 1, group H, member 2 -2.17937
LMO1 LIM domain only 1 (rhombotin 1) -2.15504
JUP junction plakoglobin -2.1145
RNF111 ring finger protein 111 -2.05044
WDCP WD repeat and coiled coil containing -2.02546
CENPO centromere protein O -2.02375
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 -2.01808