CRCGN009_HEPG2_24H:F21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description kepone 9.85 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

97 genes differentially expressed following the CRCGN009_HEPG2_24H:F21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 6.93001
CNPY3 canopy FGF signaling regulator 3 5.50857
INPP1 inositol polyphosphate-1-phosphatase 4.87293
AMDHD2 amidohydrolase domain containing 2 4.63279
CDC45 cell division cycle 45 4.56463
MVP major vault protein 4.40855
STAP2 signal transducing adaptor family member 2 4.2642
SFTPB surfactant protein B 3.52728
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.52475
SNAP25 synaptosomal-associated protein, 25kDa 3.48647
KIFBP kinesin family binding protein 3.46963
UBQLN2 ubiquilin 2 3.42381
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.37883
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.22804
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.15321
TIMP2 TIMP metallopeptidase inhibitor 2 3.02076
PRR15L proline rich 15-like 2.97343
CYCS cytochrome c, somatic 2.95486
CIAO3 cytosolic iron-sulfur assembly component 3 2.76588
ADRB2 adrenoceptor beta 2, surface 2.76017
ACOT9 acyl-CoA thioesterase 9 2.73699
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.72175
GSTZ1 glutathione S-transferase zeta 1 2.69893
LCN2 lipocalin 2 2.68359
TRIB3 tribbles pseudokinase 3 2.66729
TUBB6 tubulin, beta 6 class V 2.65126
TRIB1 tribbles pseudokinase 1 2.5687
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.55752
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.52776
EPHA3 EPH receptor A3 2.49848
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.47758
EGR1 early growth response 1 2.46903
PCDHB11 protocadherin beta 11 2.40032
PFDN2 prefoldin subunit 2 2.36373
SQSTM1 sequestosome 1 2.34515
TOMM34 translocase of outer mitochondrial membrane 34 2.32817
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.30135
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.28905
GLRX glutaredoxin (thioltransferase) 2.27724
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.26622
CBR3 carbonyl reductase 3 2.25572
TXNL4B thioredoxin-like 4B 2.24395
NANOS3 nanos homolog 3 (Drosophila) 2.23583
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.22827
DUSP6 dual specificity phosphatase 6 2.20988
DSG2 desmoglein 2 2.20923
CCP110 centriolar coiled coil protein 110kDa 2.2048
GPKOW G patch domain and KOW motifs 2.17733
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.15126
AXIN1 axin 1 2.1262
ISG15 ISG15 ubiquitin-like modifier 2.11353
SQOR sulfide quinone oxidoreductase 2.10682
MX1 MX dynamin-like GTPase 1 2.08659
SIL1 SIL1 nucleotide exchange factor 2.03706
ITGB5 integrin, beta 5 2.01862
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.01543
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.00572

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.64148
LDHD lactate dehydrogenase D -6.48582
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -6.20531
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.94615
PSRC1 proline/serine-rich coiled-coil 1 -3.72908
CD320 CD320 molecule -3.58565
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.04796
CCNB2 cyclin B2 -3.01091
TLCD3A TLC domain containing 3A -3.0006
TCTN1 tectonic family member 1 -2.99588
PCNA proliferating cell nuclear antigen -2.95325
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.94028
TXNDC9 thioredoxin domain containing 9 -2.91153
MELK maternal embryonic leucine zipper kinase -2.89926
FGFR4 fibroblast growth factor receptor 4 -2.83551
TLR4 toll-like receptor 4 -2.58044
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.57704
NISCH nischarin -2.53587
ZNF274 zinc finger protein 274 -2.52681
MTFR1 mitochondrial fission regulator 1 -2.40901
EIF5 eukaryotic translation initiation factor 5 -2.38673
PLK1 polo-like kinase 1 -2.37224
SESN1 sestrin 1 -2.35405
COG7 component of oligomeric golgi complex 7 -2.22242
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.2107
AURKB aurora kinase B -2.20928
ISOC1 isochorismatase domain containing 1 -2.15529
CTCF CCCTC-binding factor (zinc finger protein) -2.15198
HSPB1 heat shock 27kDa protein 1 -2.14144
CDK1 cyclin-dependent kinase 1 -2.12814
CTSD cathepsin D -2.11079
HMOX1 heme oxygenase 1 -2.10727
ADI1 acireductone dioxygenase 1 -2.09268
ALDOC aldolase C, fructose-bisphosphate -2.08809
CDC25B cell division cycle 25B -2.08029
HAT1 histone acetyltransferase 1 -2.07746
CDC20 cell division cycle 20 -2.04372
THAP11 THAP domain containing 11 -2.02527
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -2.02476
OXA1L oxidase (cytochrome c) assembly 1-like -2.01605