CRCGN009_HEPG2_24H:G01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description mepyramine 39.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

45 genes differentially expressed following the CRCGN009_HEPG2_24H:G01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 6.37297
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 6.35301
DYNLT3 dynein, light chain, Tctex-type 3 6.01503
SNAP25 synaptosomal-associated protein, 25kDa 5.4424
LPAR2 lysophosphatidic acid receptor 2 4.91223
STK10 serine/threonine kinase 10 3.47283
UBQLN2 ubiquilin 2 3.27008
ADGRE5 adhesion G protein-coupled receptor E5 3.15119
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.99814
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.81157
PMM2 phosphomannomutase 2 2.62004
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.47977
WDR7 WD repeat domain 7 2.47073
BAX BCL2-associated X protein 2.46667
LOC122526780 uncharacterized LOC122526780 2.44876
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.41857
MAP7 microtubule-associated protein 7 2.41508
HOXA10 homeobox A10 2.37456
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.24346
LSR lipolysis stimulated lipoprotein receptor 2.18077
GATA2 GATA binding protein 2 2.13667
GMIP GEM interacting protein 2.12269
NENF neudesin neurotrophic factor 2.11971
CHN1 chimerin 1 2.10459
FRRS1L ferric-chelate reductase 1-like 2.06863

decreased expression

Symbol Name Standardized Value
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -9.65671
ZNF586 zinc finger protein 586 -5.60128
TSEN2 TSEN2 tRNA splicing endonuclease subunit -4.15527
PRPF4 pre-mRNA processing factor 4 -3.7984
OXA1L oxidase (cytochrome c) assembly 1-like -3.72194
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.40834
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.386
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.30486
PLK1 polo-like kinase 1 -3.29308
EGF epidermal growth factor -3.2806
LOC124907782 dual specificity protein phosphatase 22 -3.26083
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.24123
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.00304
TLR4 toll-like receptor 4 -2.48564
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.45134
ZMIZ1 zinc finger, MIZ-type containing 1 -2.38097
ILK integrin-linked kinase -2.28824
MRPS16 mitochondrial ribosomal protein S16 -2.25893
SHCBP1 SHC SH2-domain binding protein 1 -2.09415
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -2.00557