CRCGN009_HEPG2_24H:G07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 9-ethyl-9h-carbazol-3-amine hydrochloride 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

127 genes differentially expressed following the CRCGN009_HEPG2_24H:G07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GSTZ1 glutathione S-transferase zeta 1 6.32953
STIMATE STIM activating enhancer 6.19698
CNPY3 canopy FGF signaling regulator 3 5.93531
VAT1 vesicle amine transport 1 5.8444
MOK MOK protein kinase 5.37107
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 4.71058
RAP1GAP RAP1 GTPase activating protein 4.61717
PPARG peroxisome proliferator-activated receptor gamma 4.60246
RRAGA Ras-related GTP binding A 4.15049
SQOR sulfide quinone oxidoreductase 4.14599
ZFP36 ZFP36 ring finger protein 4.13068
INPP1 inositol polyphosphate-1-phosphatase 4.12866
C2CD2 C2 calcium-dependent domain containing 2 4.0269
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 3.96328
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.9099
TXNRD1 thioredoxin reductase 1 3.79818
TRIB3 tribbles pseudokinase 3 3.75024
CDC45 cell division cycle 45 3.68055
CIAO3 cytosolic iron-sulfur assembly component 3 3.63792
CARMIL1 capping protein regulator and myosin 1 linker 1 3.59594
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 3.52005
SYNE2 spectrin repeat containing, nuclear envelope 2 3.38534
MVP major vault protein 3.36946
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 3.34898
ADRB2 adrenoceptor beta 2, surface 3.319
AARS1 alanyl-tRNA synthetase 1 3.27393
CTSL cathepsin L 3.25444
SQSTM1 sequestosome 1 3.25253
ABHD4 abhydrolase domain containing 4 3.12403
CHN1 chimerin 1 3.11537
CCNF cyclin F 3.09808
RPP38 ribonuclease P/MRP 38kDa subunit 3.08357
MNAT1 MNAT CDK-activating kinase assembly factor 1 3.07052
SNAP25 synaptosomal-associated protein, 25kDa 3.06908
DDIT4 DNA-damage-inducible transcript 4 3.02588
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.99148
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.98228
DYNLT3 dynein, light chain, Tctex-type 3 2.96467
TEX10 testis expressed 10 2.96212
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.93308
LCN2 lipocalin 2 2.83535
PEX11A peroxisomal biogenesis factor 11 alpha 2.76598
ADAM10 ADAM metallopeptidase domain 10 2.74959
SFTPB surfactant protein B 2.74608
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.70915
RXYLT1 ribitol xylosyltransferase 1 2.70301
CDPF1 cysteine-rich, DPF motif domain containing 1 2.65831
NANOS3 nanos homolog 3 (Drosophila) 2.53091
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 2.52178
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.48535
PHGDH phosphoglycerate dehydrogenase 2.45601
MTERF3 mitochondrial transcription termination factor 3 2.4411
MCM3 minichromosome maintenance complex component 3 2.43446
LOC122526780 uncharacterized LOC122526780 2.43223
ABHD6 abhydrolase domain containing 6 2.40291
ADGRE5 adhesion G protein-coupled receptor E5 2.3432
INTS3 integrator complex subunit 3 2.34195
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.32782
STXBP2 syntaxin binding protein 2 2.30504
CDK19 cyclin-dependent kinase 19 2.25606
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific 2.21198
GAA glucosidase, alpha; acid 2.2039
PYGL phosphorylase, glycogen, liver 2.19652
KEAP1 kelch-like ECH-associated protein 1 2.18736
RIOX2 ribosomal oxygenase 2 2.15258
PAK1IP1 PAK1 interacting protein 1 2.15164
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.14519
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.14284
ICAM1 intercellular adhesion molecule 1 2.12313
XPOT exportin, tRNA 2.11873
RPL39L ribosomal protein L39-like 2.10176
STAP2 signal transducing adaptor family member 2 2.08641
HABP4 hyaluronan binding protein 4 2.07891
TBPL1 TBP-like 1 2.06731
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.06318
MBIP MAP3K12 binding inhibitory protein 1 2.02482
UBE3C ubiquitin protein ligase E3C 2.02412
JADE2 jade family PHD finger 2 2.02361

decreased expression

Symbol Name Standardized Value
CASP7 caspase 7, apoptosis-related cysteine peptidase -8.75061
KDM3A lysine (K)-specific demethylase 3A -6.76474
PCNA proliferating cell nuclear antigen -6.2306
DNM1L dynamin 1-like -6.19298
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -5.47368
CDC20 cell division cycle 20 -5.02396
TCTN1 tectonic family member 1 -4.65381
NRIP1 nuclear receptor interacting protein 1 -3.4104
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -3.41011
PEG10 paternally expressed 10 -3.34691
PECR peroxisomal trans-2-enoyl-CoA reductase -3.29972
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.28188
CCNB2 cyclin B2 -3.26223
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.21101
CDK1 cyclin-dependent kinase 1 -3.20667
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.20134
RNASE7 ribonuclease, RNase A family, 7 -3.13732
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.11946
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.10426
LDHD lactate dehydrogenase D -3.03475
AURKB aurora kinase B -3.01321
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.98393
PGAM4 phosphoglycerate mutase family member 4 -2.98258
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.74908
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.74502
PDZD2 PDZ domain containing 2 -2.74264
ZNF274 zinc finger protein 274 -2.6373
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.60129
PSRC1 proline/serine-rich coiled-coil 1 -2.59722
FBXL12 F-box and leucine-rich repeat protein 12 -2.47781
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.47219
HSPA1A heat shock 70kDa protein 1A -2.43156
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.42974
SLC46A3 solute carrier family 46, member 3 -2.39244
YME1L1 YME1-like 1 ATPase -2.37152
MELK maternal embryonic leucine zipper kinase -2.34077
EGF epidermal growth factor -2.33286
PLK1 polo-like kinase 1 -2.33063
CAB39 calcium binding protein 39 -2.30809
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.27619
GTF2A2 general transcription factor IIA, 2, 12kDa -2.23444
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.18162
FHL2 four and a half LIM domains 2 -2.1491
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.13354
ALDOC aldolase C, fructose-bisphosphate -2.11873
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.11734
CAPRIN2 caprin family member 2 -2.06416
PKP2 plakophilin 2 -2.01797
ARFIP2 ADP-ribosylation factor interacting protein 2 -2.01312