CRCGN009_HEPG2_24H:G11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 9-ethyl-9h-carbazol-3-amine hydrochloride 2.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

57 genes differentially expressed following the CRCGN009_HEPG2_24H:G11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RAB11FIP1 RAB11 family interacting protein 1 (class I) 4.91349
LCN2 lipocalin 2 4.87714
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.81992
E2F2 E2F transcription factor 2 4.72979
CHMP6 charged multivesicular body protein 6 4.69998
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.62624
HLA-DMA major histocompatibility complex, class II, DM alpha 4.44815
MINDY1 MINDY lysine 48 deubiquitinase 1 4.42747
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.4253
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.21769
NOTCH1 notch 1 4.1425
DENND2D DENN/MADD domain containing 2D 3.71037
DIPK1A divergent protein kinase domain 1A 3.59811
MAP7 microtubule-associated protein 7 3.57187
RAB21 RAB21, member RAS oncogene family 3.57055
CCL2 chemokine (C-C motif) ligand 2 3.24978
HLA-DRA major histocompatibility complex, class II, DR alpha 3.16436
PFKL phosphofructokinase, liver 3.08777
SFTPB surfactant protein B 2.5779
CHN1 chimerin 1 2.47574
RRAGA Ras-related GTP binding A 2.46555
TPD52L2 tumor protein D52-like 2 2.44271
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 2.37515
EGF epidermal growth factor 2.34122
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.28442
CASQ2 calsequestrin 2 (cardiac muscle) 2.25525
GPATCH8 G patch domain containing 8 2.2484
TRAT1 T cell receptor associated transmembrane adaptor 1 2.23167
MUC7 mucin 7, secreted 2.23065
GATD3 glutamine amidotransferase class 1 domain containing 3 2.22524
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 2.22228
ZNF280A zinc finger protein 280A 2.2136
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.16856
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.15816
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.13833
LDB3 LIM domain binding 3 2.09336
EPHA3 EPH receptor A3 2.08022
YOD1 YOD1 deubiquitinase 2.07165
MYOZ1 myozenin 1 2.05001
HOXC11 homeobox C11 2.04262
SOBP sine oculis binding protein homolog (Drosophila) 2.01376

decreased expression

Symbol Name Standardized Value
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -9.45302
OXA1L oxidase (cytochrome c) assembly 1-like -5.32667
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.13484
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.91377
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.72006
SCAND1 SCAN domain containing 1 -4.53172
DERA deoxyribose-phosphate aldolase (putative) -4.39603
CD320 CD320 molecule -4.027
HEATR1 HEAT repeat containing 1 -3.94852
TSEN2 TSEN2 tRNA splicing endonuclease subunit -3.92491
CCNB2 cyclin B2 -3.35857
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -3.10952
PECR peroxisomal trans-2-enoyl-CoA reductase -2.45308
ZNF692 zinc finger protein 692 -2.41704
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.37344
TRAPPC6A trafficking protein particle complex 6A -2.29469