CRCGN009_HEPG2_24H:G12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 9-ethyl-9h-carbazol-3-amine hydrochloride 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

50 genes differentially expressed following the CRCGN009_HEPG2_24H:G12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 7.40572
TIAM1 T-cell lymphoma invasion and metastasis 1 6.34002
TAC4 tachykinin 4 (hemokinin) 4.19205
SOCS2 suppressor of cytokine signaling 2 3.86011
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.80298
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.7876
RAB11FIP1 RAB11 family interacting protein 1 (class I) 3.77226
HLA-DMA major histocompatibility complex, class II, DM alpha 3.76569
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.39119
BACE2 beta-site APP-cleaving enzyme 2 3.2808
CEP57 centrosomal protein 57kDa 2.82103
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.6735
MAMLD1 mastermind-like domain containing 1 2.64335
CEMIP2 cell migration inducing hyaluronidase 2 2.61196
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 2.602
DHDDS dehydrodolichyl diphosphate synthase 2.55091
IGHMBP2 immunoglobulin mu binding protein 2 2.51316
CIAO3 cytosolic iron-sulfur assembly component 3 2.44661
GPATCH8 G patch domain containing 8 2.38132
PPCS phosphopantothenoylcysteine synthetase 2.34414
NOTCH1 notch 1 2.31505
HEBP1 heme binding protein 1 2.30501
PEX11A peroxisomal biogenesis factor 11 alpha 2.26742
ABHD6 abhydrolase domain containing 6 2.25707
RPL39L ribosomal protein L39-like 2.23808
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.12223
PLSCR1 phospholipid scramblase 1 2.03433
FANCF Fanconi anemia, complementation group F 2.00279
CA14 carbonic anhydrase XIV 2.00128

decreased expression

Symbol Name Standardized Value
TLR4 toll-like receptor 4 -5.97094
PCNA proliferating cell nuclear antigen -5.44715
CCNB2 cyclin B2 -4.56686
NIT1 nitrilase 1 -4.24333
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -3.96979
LOC124907782 dual specificity protein phosphatase 22 -3.88415
KDM3A lysine (K)-specific demethylase 3A -3.73345
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.71296
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.49519
PTPRK protein tyrosine phosphatase, receptor type, K -3.18017
YME1L1 YME1-like 1 ATPase -2.76117
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.74039
HMG20B high mobility group 20B -2.69113
RNF167 ring finger protein 167 -2.62972
ITGB1BP1 integrin beta 1 binding protein 1 -2.46531
EGF epidermal growth factor -2.42629
WASHC4 WASH complex subunit 4 -2.32731
LDHD lactate dehydrogenase D -2.29144
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.08184
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.03754
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.01206