CRCGN009_HEPG2_24H:G16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description withaferin-a 2.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

599 genes differentially expressed following the CRCGN009_HEPG2_24H:G16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABHD4 abhydrolase domain containing 4 10.0
MCOLN1 mucolipin 1 9.91083
KLHL21 kelch-like family member 21 9.80295
LCN2 lipocalin 2 9.57236
TIMP2 TIMP metallopeptidase inhibitor 2 9.28115
CTSL cathepsin L 9.09615
TXNRD1 thioredoxin reductase 1 9.01175
HSPA1A heat shock 70kDa protein 1A 8.81704
HMOX1 heme oxygenase 1 8.29664
CBR1 carbonyl reductase 1 7.28698
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 7.20211
CNPY3 canopy FGF signaling regulator 3 6.86472
SQSTM1 sequestosome 1 6.36592
FOSL1 FOS-like antigen 1 6.27323
MVP major vault protein 6.0851
H2BC12 H2B clustered histone 12 6.02132
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 5.84578
FOXO4 forkhead box O4 5.80432
ALAS1 5'-aminolevulinate synthase 1 5.79955
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 5.69319
KDM3A lysine (K)-specific demethylase 3A 5.67614
BAG3 BCL2-associated athanogene 3 5.49951
ADI1 acireductone dioxygenase 1 5.46147
NPC1 Niemann-Pick disease, type C1 5.40305
TXNL4B thioredoxin-like 4B 5.15305
DNM1L dynamin 1-like 5.10693
AMDHD2 amidohydrolase domain containing 2 5.10454
TMEM50A transmembrane protein 50A 4.86492
LRP10 low density lipoprotein receptor-related protein 10 4.84752
RBKS ribokinase 4.81658
TEX10 testis expressed 10 4.79374
TATDN2 TatD DNase domain containing 2 4.78046
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 4.58518
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 4.50173
CDPF1 cysteine-rich, DPF motif domain containing 1 4.49571
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 4.49086
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 4.45393
TERF2IP telomeric repeat binding factor 2, interacting protein 4.43843
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa 4.41562
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.27275
UGDH UDP-glucose 6-dehydrogenase 4.12763
ZNF589 zinc finger protein 589 4.11181
TBPL1 TBP-like 1 4.03024
KEAP1 kelch-like ECH-associated protein 1 3.92962
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 3.84524
RNMT RNA (guanine-7-) methyltransferase 3.82283
RNASE7 ribonuclease, RNase A family, 7 3.82182
VAT1 vesicle amine transport 1 3.78759
GOLT1B golgi transport 1B 3.78668
IGHMBP2 immunoglobulin mu binding protein 2 3.78577
PRKCD protein kinase C, delta 3.7754
RAB11FIP1 RAB11 family interacting protein 1 (class I) 3.74292
ANO10 anoctamin 10 3.72772
EAPP E2F-associated phosphoprotein 3.6427
DUSP3 dual specificity phosphatase 3 3.62586
RIOK3 RIO kinase 3 3.53777
BLCAP bladder cancer associated protein 3.53149
CAB39 calcium binding protein 39 3.51237
CARMIL1 capping protein regulator and myosin 1 linker 1 3.51208
CDC25B cell division cycle 25B 3.48964
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.48226
ECD ecdysoneless homolog (Drosophila) 3.42967
ARID4B AT rich interactive domain 4B (RBP1-like) 3.4257
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3.35309
ANO1 anoctamin 1, calcium activated chloride channel 3.35153
OSER1 oxidative stress responsive serine-rich 1 3.33407
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 3.30278
YPEL5 yippee-like 5 (Drosophila) 3.28862
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.28718
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 3.26007
RALB v-ral simian leukemia viral oncogene homolog B 3.24717
NOTCH1 notch 1 3.24514
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.22292
TWF2 twinfilin actin binding protein 2 3.18465
MNAT1 MNAT CDK-activating kinase assembly factor 1 3.1803
INPP1 inositol polyphosphate-1-phosphatase 3.1793
ADRM1 adhesion regulating molecule 1 3.16458
COQ10B coenzyme Q10 homolog B (S. cerevisiae) 3.16044
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 3.15724
CGRRF1 cell growth regulator with ring finger domain 1 3.15593
RMC1 regulator of MON1-CCZ1 3.15002
GNPDA1 glucosamine-6-phosphate deaminase 1 3.14163
NCOA3 nuclear receptor coactivator 3 3.10633
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 3.10032
PLEKHO2 pleckstrin homology domain containing, family O member 2 3.08851
ELF4 E74-like factor 4 (ets domain transcription factor) 3.06442
MALT1 MALT1 paracaspase 3.05728
STXBP1 syntaxin binding protein 1 3.05155
IGF1R insulin-like growth factor 1 receptor 3.04649
FASTKD5 FAST kinase domains 5 3.03238
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 3.02793
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.02772
RAB5IF RAB5 interacting factor 2.99923
GCLM glutamate-cysteine ligase, modifier subunit 2.98124
TMEM127 transmembrane protein 127 2.97556
PTK2 protein tyrosine kinase 2 2.95759
MOSPD1 motile sperm domain containing 1 2.95396
EMC3 ER membrane protein complex subunit 3 2.94423
RAB21 RAB21, member RAS oncogene family 2.92145
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 2.91531
LOC124907782 dual specificity protein phosphatase 22 2.90346
CYCS cytochrome c, somatic 2.89243
GRN granulin 2.88966
GHITM growth hormone inducible transmembrane protein 2.88779
PGRMC1 progesterone receptor membrane component 1 2.8456
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 2.82578
ARL8B ADP-ribosylation factor-like 8B 2.82239
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.81866
TPD52L2 tumor protein D52-like 2 2.81408
SMAD3 SMAD family member 3 2.79906
ZFAND3 zinc finger, AN1-type domain 3 2.78825
BTG3 BTG family, member 3 2.7735
RNF113A ring finger protein 113A 2.77346
PELO pelota homolog (Drosophila) 2.7648
LOC128125814 uncharacterized LOC128125814 2.75629
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 2.74883
RND3 Rho family GTPase 3 2.74842
ANKRD12 ankyrin repeat domain 12 2.745
ATG14 autophagy related 14 2.7435
OSGIN1 oxidative stress induced growth inhibitor 1 2.72531
ISCA1 iron-sulfur cluster assembly 1 2.70691
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit 2.702
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 2.69185
EEIG1 estrogen-induced osteoclastogenesis regulator 1 2.6822
KCTD9 potassium channel tetramerization domain containing 9 2.67237
SLC38A6 solute carrier family 38, member 6 2.66749
TRAK2 trafficking protein, kinesin binding 2 2.66439
NAA60 N(alpha)-acetyltransferase 60, NatF catalytic subunit 2.6608
TUFT1 tuftelin 1 2.65997
SH3GL1 SH3-domain GRB2-like 1 2.65763
TMEM59 transmembrane protein 59 2.65508
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 2.64342
MICB MHC class I polypeptide-related sequence B 2.64063
RAB9A RAB9A, member RAS oncogene family 2.63996
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.63797
GPER1 G protein-coupled estrogen receptor 1 2.6253
CLTC clathrin, heavy chain (Hc) 2.61387
SP140 SP140 nuclear body protein 2.61017
FLNC filamin C, gamma 2.60974
ABI1 abl-interactor 1 2.59993
BTG1 B-cell translocation gene 1, anti-proliferative 2.59363
CIRSR corepressor of RBPJ and splicing regulator 2.58432
MXI1 MAX interactor 1, dimerization protein 2.57818
TBCC tubulin folding cofactor C 2.5735
GPC1 glypican 1 2.57285
YAF2 YY1 associated factor 2 2.56825
PTPN1 protein tyrosine phosphatase, non-receptor type 1 2.56105
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 2.55608
RNF114 ring finger protein 114 2.55127
TP53BP2 tumor protein p53 binding protein 2 2.54994
LGMN legumain 2.52863
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.51903
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 2.51498
GBA1 glucosylceramidase beta 1 2.50854
TMCO1 transmembrane and coiled-coil domains 1 2.49968
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 2.49631
BMP4 bone morphogenetic protein 4 2.48778
IFT20 intraflagellar transport 20 2.4718
UBXN7 UBX domain protein 7 2.46752
GTF2B general transcription factor IIB 2.45214
TESK1 testis-specific kinase 1 2.44805
ALAS2 5'-aminolevulinate synthase 2 2.44685
SERTAD2 SERTA domain containing 2 2.44227
GABARAPL1 GABA(A) receptor-associated protein like 1 2.44186
ZNF586 zinc finger protein 586 2.44129
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.43289
AXIN1 axin 1 2.4297
FBXO7 F-box protein 7 2.42935
HDGFL3 HDGF like 3 2.42316
GAGE8 G antigen 8 2.42243
H2AC19 H2A clustered histone 19 2.41629
SCAMP4 secretory carrier membrane protein 4 2.40898
RNF122 ring finger protein 122 2.40883
TSTD2 thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 2.40832
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma 2.37368
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 2.3728
PI3 peptidase inhibitor 3, skin-derived 2.36693
CSNK1G3 casein kinase 1, gamma 3 2.36084
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 2.35632
LSG1 large 60S subunit nuclear export GTPase 1 2.35623
ZNF14 zinc finger protein 14 2.35357
DNASE1L3 deoxyribonuclease I-like 3 2.35332
SDCBP syndecan binding protein (syntenin) 2.35318
MAD2L1BP MAD2L1 binding protein 2.35267
DNM1 dynamin 1 2.35195
MPPE1 metallophosphoesterase 1 2.34951
FERRY3 FERRY endosomal RAB5 effector complex subunit 3 2.34711
IL3RA interleukin 3 receptor, alpha (low affinity) 2.34693
CD48 CD48 molecule 2.34628
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.34447
BRMS1L breast cancer metastasis-suppressor 1-like 2.34444
TTC1 tetratricopeptide repeat domain 1 2.34298
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 2.33921
PHTF1 putative homeodomain transcription factor 1 2.33599
SCPEP1 serine carboxypeptidase 1 2.33555
FEM1C fem-1 homolog c (C. elegans) 2.33426
GPATCH8 G patch domain containing 8 2.33014
C6ORF89 chromosome 6 open reading frame 89 2.32641
GCC1 GRIP and coiled-coil domain containing 1 2.3185
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.31847
CDK7 cyclin-dependent kinase 7 2.31562
ADGRG3 adhesion G protein-coupled receptor G3 2.31516
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein 2.3147
SLC10A3 solute carrier family 10, member 3 2.31392
DNM2 dynamin 2 2.31276
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 2.30877
GPATCH3 G patch domain containing 3 2.30076
RNF4 ring finger protein 4 2.29989
UFD1 ubiquitin recognition factor in ER associated degradation 1 2.29986
FZD10 frizzled class receptor 10 2.29893
MAGEA4 melanoma antigen family A4 2.29504
BMAL1 basic helix-loop-helix ARNT like 1 2.29487
DAZAP2 DAZ associated protein 2 2.29261
ZNF556 zinc finger protein 556 2.28433
IL21R interleukin 21 receptor 2.27971
YTHDC1 YTH domain containing 1 2.27757
NIBAN1 niban apoptosis regulator 1 2.27625
CTSA cathepsin A 2.27309
SH3GLB1 SH3-domain GRB2-like endophilin B1 2.26933
NME8 NME/NM23 family member 8 2.26777
ZNF212 zinc finger protein 212 2.26677
ZNF222 zinc finger protein 222 2.2598
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 2.25847
RTN4 reticulon 4 2.255
TLK2 tousled-like kinase 2 2.25314
STX4 syntaxin 4 2.24679
RRAGC Ras-related GTP binding C 2.24655
HSPA1B heat shock 70kDa protein 1B 2.2435
ELL2 elongation factor, RNA polymerase II, 2 2.2433
PCDHGA9 protocadherin gamma subfamily A, 9 2.24089
PAGE1 P antigen family, member 1 (prostate associated) 2.23794
SDC4 syndecan 4 2.22935
CBX6 chromobox homolog 6 2.22741
GADD45B growth arrest and DNA-damage-inducible, beta 2.22584
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 2.22498
PRKCQ protein kinase C, theta 2.22277
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H 2.22043
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 2.21899
RPP38 ribonuclease P/MRP 38kDa subunit 2.21302
CEP57 centrosomal protein 57kDa 2.21075
H2BC21 H2B clustered histone 21 2.20614
COTL1 coactosin-like F-actin binding protein 1 2.20227
HCCS holocytochrome c synthase 2.19973
MAPRE1 microtubule-associated protein, RP/EB family, member 1 2.18711
RRAS2 related RAS viral (r-ras) oncogene homolog 2 2.18193
ZC3H15 zinc finger CCCH-type containing 15 2.18109
UBQLN2 ubiquilin 2 2.18028
PLSCR1 phospholipid scramblase 1 2.17874
VAMP7 vesicle-associated membrane protein 7 2.17534
TBC1D10C TBC1 domain family, member 10C 2.17492
CD2AP CD2-associated protein 2.17455
ELL elongation factor RNA polymerase II 2.17171
STX5 syntaxin 5 2.17135
TNFAIP8L2-SCNM1 TNFAIP8L2-SCNM1 readthrough 2.16977
SMAP1 small ArfGAP 1 2.16491
TM9SF2 transmembrane 9 superfamily member 2 2.16369
OFD1 oral-facial-digital syndrome 1 2.16251
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa 2.1597
WIPF2 WAS/WASL interacting protein family, member 2 2.15831
CHIT1 chitinase 1 (chitotriosidase) 2.15604
SMIM29 small integral membrane protein 29 2.14945
INPPL1 inositol polyphosphate phosphatase-like 1 2.14761
DCAF6 DDB1 and CUL4 associated factor 6 2.14473
PLSCR3 phospholipid scramblase 3 2.1442
IST1 increased sodium tolerance 1 homolog (yeast) 2.14387
CCDC91 coiled-coil domain containing 91 2.14294
LEMD3 LEM domain containing 3 2.14047
RB1CC1 RB1-inducible coiled-coil 1 2.14014
FURIN furin (paired basic amino acid cleaving enzyme) 2.12844
TBC1D15 TBC1 domain family, member 15 2.12743
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.12283
MICALL1 MICAL-like 1 2.12099
FAM53C family with sequence similarity 53, member C 2.11855
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 2.11815
GMNN geminin, DNA replication inhibitor 2.11169
STX3 syntaxin 3 2.11
ZYX zyxin 2.10718
FAM13B family with sequence similarity 13, member B 2.10305
SYF2 SYF2 pre-mRNA-splicing factor 2.0991
CCL3L3 chemokine (C-C motif) ligand 3-like 3 2.09874
DPP3 dipeptidyl-peptidase 3 2.09609
SOD1 superoxide dismutase 1, soluble 2.0935
BAK1 BCL2-antagonist/killer 1 2.09317
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 2.09003
RXYLT1 ribitol xylosyltransferase 1 2.08853
PSMG2 proteasome (prosome, macropain) assembly chaperone 2 2.08764
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1 2.08627
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 2.07542
CDK9 cyclin-dependent kinase 9 2.07528
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G 2.07459
UBR2 ubiquitin protein ligase E3 component n-recognin 2 2.07027
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 2.06997
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 2.06813
IL2RB interleukin 2 receptor, beta 2.06248
DEFA4 defensin, alpha 4, corticostatin 2.06106
UGCG UDP-glucose ceramide glucosyltransferase 2.0551
KLRB1 killer cell lectin-like receptor subfamily B, member 1 2.05389
ZMPSTE24 zinc metallopeptidase STE24 2.05389
ACTL8 actin-like 8 2.05116
WNT11 wingless-type MMTV integration site family, member 11 2.04693
ASB6 ankyrin repeat and SOCS box containing 6 2.04592
LGALS8 lectin, galactoside-binding, soluble, 8 2.04381
BICRA BRD4 interacting chromatin remodeling complex associated protein 2.04325
CHN1 chimerin 1 2.04309
PERP PERP, TP53 apoptosis effector 2.04028
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 2.03877
CLTB clathrin, light chain B 2.03714
LRRC41 leucine rich repeat containing 41 2.0364
TFE3 transcription factor binding to IGHM enhancer 3 2.03499
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 2.03428
FTH1 ferritin, heavy polypeptide 1 2.02583
MYT1 myelin transcription factor 1 2.02517
TRAPPC3 trafficking protein particle complex 3 2.02476
JOSD1 Josephin domain containing 1 2.02143
ZNF394 zinc finger protein 394 2.01985
CYLD cylindromatosis (turban tumor syndrome) 2.01961
CDKL3 cyclin-dependent kinase-like 3 2.01946
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) 2.01645
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 2.01469
HSPH1 heat shock 105kDa/110kDa protein 1 2.01465
NSUN3 NOP2/Sun domain family, member 3 2.01165
RABEP2 rabaptin, RAB GTPase binding effector protein 2 2.01109
EHBP1L1 EH domain binding protein 1-like 1 2.01022
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1 2.00989
AKR1C1 aldo-keto reductase family 1, member C1 2.00899
ZW10 zw10 kinetochore protein 2.00738
COL17A1 collagen, type XVII, alpha 1 2.00625
YES1 YES proto-oncogene 1, Src family tyrosine kinase 2.00429
EDN3 endothelin 3 2.00286
BPI bactericidal/permeability-increasing protein 2.00276
TSPAN3 tetraspanin 3 2.00077

decreased expression

Symbol Name Standardized Value
PCCB propionyl CoA carboxylase, beta polypeptide -10.0
COG2 component of oligomeric golgi complex 2 -10.0
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -9.3732
CD320 CD320 molecule -9.22001
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -9.01859
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -8.00653
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -7.99336
INTS3 integrator complex subunit 3 -7.53175
B4GAT1 beta-1,4-glucuronyltransferase 1 -7.40396
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -7.14539
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.84138
RPS4Y1 ribosomal protein S4, Y-linked 1 -6.64847
C2CD5 C2 calcium-dependent domain containing 5 -6.4776
ISOC1 isochorismatase domain containing 1 -6.41525
TOP2A topoisomerase (DNA) II alpha 170kDa -6.19558
FGFR4 fibroblast growth factor receptor 4 -6.13011
NT5DC2 5'-nucleotidase domain containing 2 -6.03547
TLR4 toll-like receptor 4 -5.96324
NUP85 nucleoporin 85kDa -5.95279
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.78752
STK25 serine/threonine kinase 25 -5.67271
RPIA ribose 5-phosphate isomerase A -5.64972
CDC20 cell division cycle 20 -5.60919
LBR lamin B receptor -5.50586
PLS1 plastin 1 -5.29006
MELK maternal embryonic leucine zipper kinase -5.26722
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -5.23165
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -5.17368
UBE3C ubiquitin protein ligase E3C -5.16709
CCNB1 cyclin B1 -5.13705
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -5.1235
HEATR1 HEAT repeat containing 1 -5.12125
GET1 guided entry of tail-anchored proteins factor 1 -5.11116
OXA1L oxidase (cytochrome c) assembly 1-like -5.06529
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -5.02847
TRAP1 TNF receptor-associated protein 1 -5.01369
GLOD4 glyoxalase domain containing 4 -4.90627
PSRC1 proline/serine-rich coiled-coil 1 -4.90019
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -4.83254
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -4.78947
PYCR1 pyrroline-5-carboxylate reductase 1 -4.77769
DPH2 DPH2 homolog (S. cerevisiae) -4.77333
STAMBP STAM binding protein -4.74261
TCEAL4 transcription elongation factor A (SII)-like 4 -4.73464
CCNA2 cyclin A2 -4.73077
ENOPH1 enolase-phosphatase 1 -4.71033
CCNB2 cyclin B2 -4.69912
PXMP2 peroxisomal membrane protein 2, 22kDa -4.51334
HADH hydroxyacyl-CoA dehydrogenase -4.51118
HMGA2 high mobility group AT-hook 2 -4.49586
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -4.44952
NISCH nischarin -4.37137
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -4.36957
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -4.33896
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.31533
COG7 component of oligomeric golgi complex 7 -4.21131
PGM1 phosphoglucomutase 1 -4.2094
TSPAN4 tetraspanin 4 -4.19063
NNT nicotinamide nucleotide transhydrogenase -4.1381
MAPK13 mitogen-activated protein kinase 13 -4.1276
MRPS7 mitochondrial ribosomal protein S7 -4.1045
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) -4.0887
ERBB2 erb-b2 receptor tyrosine kinase 2 -4.06355
CDK1 cyclin-dependent kinase 1 -4.05198
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.95703
AURKB aurora kinase B -3.94638
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.92574
TSEN2 TSEN2 tRNA splicing endonuclease subunit -3.9176
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -3.90587
MRPL19 mitochondrial ribosomal protein L19 -3.82856
SCARB1 scavenger receptor class B, member 1 -3.80878
CEMIP2 cell migration inducing hyaluronidase 2 -3.77984
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.643
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.62204
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.61928
MYLK myosin light chain kinase -3.60309
MRPL58 mitochondrial ribosomal protein L58 -3.56219
CSK c-src tyrosine kinase -3.55231
CDK4 cyclin-dependent kinase 4 -3.54263
PFAS phosphoribosylformylglycinamidine synthase -3.53003
PCNA proliferating cell nuclear antigen -3.52766
STMN1 stathmin 1 -3.48937
DMAC2L distal membrane arm assembly component 2 like -3.47679
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -3.4766
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -3.40457
DDB2 damage-specific DNA binding protein 2, 48kDa -3.38103
NFIL3 nuclear factor, interleukin 3 regulated -3.38047
MRPS16 mitochondrial ribosomal protein S16 -3.37941
MCM3 minichromosome maintenance complex component 3 -3.37766
UNG uracil-DNA glycosylase -3.36905
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.36717
DNAAF5 dynein, axonemal, assembly factor 5 -3.32517
MRPS2 mitochondrial ribosomal protein S2 -3.30376
PECR peroxisomal trans-2-enoyl-CoA reductase -3.29419
PEG3 paternally expressed 3 -3.27058
FBXL4 F-box and leucine-rich repeat protein 4 -3.18836
NIPSNAP1 nipsnap homolog 1 (C. elegans) -3.16553
ACOD1 aconitate decarboxylase 1 -3.15459
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.10141
NENF neudesin neurotrophic factor -3.0708
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 -3.06717
STAP2 signal transducing adaptor family member 2 -3.05003
PYGL phosphorylase, glycogen, liver -3.02546
BZW2 basic leucine zipper and W2 domains 2 -3.00605
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.98281
KIF4A kinesin family member 4A -2.96735
TCTN1 tectonic family member 1 -2.96311
CHEK1 checkpoint kinase 1 -2.9592
TLCD3A TLC domain containing 3A -2.94087
PDHB pyruvate dehydrogenase (lipoamide) beta -2.93858
HEBP1 heme binding protein 1 -2.9345
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.9241
ZNF692 zinc finger protein 692 -2.90793
APEH acylaminoacyl-peptide hydrolase -2.86142
RFC2 replication factor C (activator 1) 2, 40kDa -2.82682
NCAPD2 non-SMC condensin I complex, subunit D2 -2.82372
ZNF318 zinc finger protein 318 -2.81674
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -2.81296
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 -2.81215
NUP133 nucleoporin 133kDa -2.81156
TSPAN6 tetraspanin 6 -2.79238
MRPL23 mitochondrial ribosomal protein L23 -2.7749
RANGRF RAN guanine nucleotide release factor -2.76927
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.7544
DCK deoxycytidine kinase -2.74798
IFRD2 interferon-related developmental regulator 2 -2.72685
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae) -2.72209
IGFBP7 insulin-like growth factor binding protein 7 -2.70865
TMEM97 transmembrane protein 97 -2.69053
KANSL1 KAT8 regulatory NSL complex subunit 1 -2.68792
ZDHHC6 zinc finger, DHHC-type containing 6 -2.68464
TFDP1 transcription factor Dp-1 -2.66783
DSG2 desmoglein 2 -2.66586
MRPL12 mitochondrial ribosomal protein L12 -2.66264
PREB prolactin regulatory element binding -2.65454
CD99 CD99 molecule -2.65367
ASGR1 asialoglycoprotein receptor 1 -2.64277
MYO10 myosin X -2.6162
MCAT malonyl CoA:ACP acyltransferase (mitochondrial) -2.60564
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 -2.60438
MSH6 mutS homolog 6 -2.60083
RUVBL1 RuvB-like AAA ATPase 1 -2.59541
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.58231
ABHD11 abhydrolase domain containing 11 -2.57614
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.57394
KIF15 kinesin family member 15 -2.57383
CHMP4B charged multivesicular body protein 4B -2.57037
DTYMK deoxythymidylate kinase (thymidylate kinase) -2.56518
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.56284
EVL Enah/Vasp-like -2.54563
NCAPG2 non-SMC condensin II complex, subunit G2 -2.54474
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) -2.54227
SUMO4 small ubiquitin-like modifier 4 -2.5401
RHOBTB1 Rho-related BTB domain containing 1 -2.53
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -2.52419
ETFB electron-transfer-flavoprotein, beta polypeptide -2.524
WASHC4 WASH complex subunit 4 -2.519
EREG epiregulin -2.51507
RBM15B RNA binding motif protein 15B -2.50751
GPS1 G protein pathway suppressor 1 -2.48976
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.48464
ICAM2 intercellular adhesion molecule 2 -2.46739
MEGF8 multiple EGF-like-domains 8 -2.46581
B9D1 B9 protein domain 1 -2.46464
FOXM1 forkhead box M1 -2.45971
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -2.45221
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 -2.44857
TRIP13 thyroid hormone receptor interactor 13 -2.44698
PGAM4 phosphoglycerate mutase family member 4 -2.44472
CRTAP cartilage associated protein -2.43927
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa -2.43797
PCYOX1 prenylcysteine oxidase 1 -2.43591
CZIB CXXC motif containing zinc binding protein -2.43466
ERBB3 erb-b2 receptor tyrosine kinase 3 -2.42446
CENPE centromere protein E, 312kDa -2.42196
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa -2.41891
PAQR6 progestin and adipoQ receptor family member VI -2.41621
USP1 ubiquitin specific peptidase 1 -2.41333
TFB1M transcription factor B1, mitochondrial -2.40926
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -2.40855
PCID2 PCI domain containing 2 -2.40808
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit -2.4023
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative) -2.38244
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.36426
CHEK2 checkpoint kinase 2 -2.34849
E2F5 E2F transcription factor 5, p130-binding -2.3484
SOAT2 sterol O-acyltransferase 2 -2.34084
MANSC1 MANSC domain containing 1 -2.33702
ARSJ arylsulfatase family, member J -2.3245
ACTA2 actin, alpha 2, smooth muscle, aorta -2.32388
ASGR2 asialoglycoprotein receptor 2 -2.31583
NEK4 NIMA-related kinase 4 -2.3129
MYO5C myosin VC -2.3027
POLD2 polymerase (DNA directed), delta 2, accessory subunit -2.30226
ESRP2 epithelial splicing regulatory protein 2 -2.28722
CGREF1 cell growth regulator with EF-hand domain 1 -2.28659
KIF11 kinesin family member 11 -2.28378
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 -2.28175
AMT aminomethyltransferase -2.27965
GNG3 guanine nucleotide binding protein (G protein), gamma 3 -2.27189
NUBPL nucleotide binding protein-like -2.27018
DUS1L dihydrouridine synthase 1-like (S. cerevisiae) -2.25252
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.25244
LCAT lecithin-cholesterol acyltransferase -2.25116
NEIL3 nei endonuclease VIII-like 3 (E. coli) -2.25104
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -2.24617
TBC1D8B TBC1 domain family, member 8B (with GRAM domain) -2.23023
COA3 cytochrome c oxidase assembly factor 3 -2.22812
MRPL57 mitochondrial ribosomal protein L57 -2.22664
MYL9 myosin, light chain 9, regulatory -2.22113
AHCY adenosylhomocysteinase -2.21786
RBFA ribosome binding factor A (putative) -2.21661
DCXR dicarbonyl/L-xylulose reductase -2.21327
PIGV phosphatidylinositol glycan anchor biosynthesis, class V -2.2121
CA9 carbonic anhydrase IX -2.21005
ZNF83 zinc finger protein 83 -2.20989
MARCKSL1 MARCKS-like 1 -2.20953
ARL6IP4 ADP-ribosylation factor-like 6 interacting protein 4 -2.20165
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.19979
UQCRC1 ubiquinol-cytochrome c reductase core protein I -2.18999
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.18998
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.18219
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 -2.17918
NTM neurotrimin -2.17828
HOXB9 homeobox B9 -2.16882
SPG11 spastic paraplegia 11 (autosomal recessive) -2.16186
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.15939
RFC3 replication factor C (activator 1) 3, 38kDa -2.1562
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.15422
ACOX2 acyl-CoA oxidase 2, branched chain -2.15242
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta -2.15162
AP1AR adaptor-related protein complex 1 associated regulatory protein -2.1491
PCCA propionyl CoA carboxylase, alpha polypeptide -2.14532
ADO 2-aminoethanethiol (cysteamine) dioxygenase -2.13557
RAP1GAP2 RAP1 GTPase activating protein 2 -2.13101
DPYSL2 dihydropyrimidinase-like 2 -2.12933
MRTO4 mRNA turnover 4 homolog (S. cerevisiae) -2.12856
PDF peptide deformylase (mitochondrial) -2.11382
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -2.11271
PNKP polynucleotide kinase 3'-phosphatase -2.11123
ZWINT ZW10 interacting kinetochore protein -2.10991
SERINC5 serine incorporator 5 -2.10817
TPM1 tropomyosin 1 (alpha) -2.10191
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like -2.10114
CKMT1A creatine kinase, mitochondrial 1A -2.10066
UFL1 UFM1-specific ligase 1 -2.09849
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -2.09388
ANKRD10 ankyrin repeat domain 10 -2.09253
CENPA centromere protein A -2.0824
PGAP2 post-GPI attachment to proteins 2 -2.0821
MRPL3 mitochondrial ribosomal protein L3 -2.07965
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.07402
ZFYVE21 zinc finger, FYVE domain containing 21 -2.06705
CHMP6 charged multivesicular body protein 6 -2.0542
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 -2.05238
SYBU syntabulin (syntaxin-interacting) -2.05208
TMEM131L transmembrane 131 like -2.05045
RNASE4 ribonuclease, RNase A family, 4 -2.04684
NIT1 nitrilase 1 -2.04626
NDC1 NDC1 transmembrane nucleoporin -2.04364
ANG angiogenin, ribonuclease, RNase A family, 5 -2.04097
RPH3A rabphilin 3A -2.03826
MYH10 myosin, heavy chain 10, non-muscle -2.03524
SNRPA small nuclear ribonucleoprotein polypeptide A -2.02853
DHRS4 dehydrogenase/reductase (SDR family) member 4 -2.02754
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) -2.02722
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 -2.02607
QDPR quinoid dihydropteridine reductase -2.00734