| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | withaferin-a 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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200 genes differentially expressed following the CRCGN009_HEPG2_24H:G17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ABHD4 | abhydrolase domain containing 4 | 10.0 |
| TXNRD1 | thioredoxin reductase 1 | 8.70112 |
| HMOX1 | heme oxygenase 1 | 6.66768 |
| H2BC12 | H2B clustered histone 12 | 6.14294 |
| CNPY3 | canopy FGF signaling regulator 3 | 6.03886 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 5.87185 |
| TMEM109 | transmembrane protein 109 | 5.12418 |
| FOSL1 | FOS-like antigen 1 | 4.94008 |
| DIPK1A | divergent protein kinase domain 1A | 4.77271 |
| UGDH | UDP-glucose 6-dehydrogenase | 4.69532 |
| SQSTM1 | sequestosome 1 | 4.68213 |
| BZW2 | basic leucine zipper and W2 domains 2 | 4.67144 |
| MSRA | methionine sulfoxide reductase A | 4.30269 |
| MCOLN1 | mucolipin 1 | 4.27624 |
| RPS6KA1 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 4.16312 |
| DNTTIP2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | 4.09586 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | 4.07069 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 4.01786 |
| ZW10 | zw10 kinetochore protein | 3.8473 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 3.66577 |
| STIMATE | STIM activating enhancer | 3.64654 |
| TUBB6 | tubulin, beta 6 class V | 3.62769 |
| STK10 | serine/threonine kinase 10 | 3.52331 |
| TBPL1 | TBP-like 1 | 3.4852 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 3.39458 |
| MVP | major vault protein | 3.38354 |
| PRR15L | proline rich 15-like | 3.336 |
| KEAP1 | kelch-like ECH-associated protein 1 | 3.27006 |
| GTF2E2 | general transcription factor IIE, polypeptide 2, beta 34kDa | 3.20736 |
| CPSF4 | cleavage and polyadenylation specific factor 4, 30kDa | 3.20545 |
| PLSCR3 | phospholipid scramblase 3 | 3.1863 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 3.18071 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 3.13141 |
| DHX29 | DEAH (Asp-Glu-Ala-His) box polypeptide 29 | 3.12583 |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | 3.07025 |
| CBR1 | carbonyl reductase 1 | 2.98739 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 2.95821 |
| WDR7 | WD repeat domain 7 | 2.9107 |
| LCN2 | lipocalin 2 | 2.86569 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | 2.84241 |
| GSTZ1 | glutathione S-transferase zeta 1 | 2.84233 |
| POPDC3 | popeye domain containing 3 | 2.80979 |
| HOXA10 | homeobox A10 | 2.79658 |
| BIRC2 | baculoviral IAP repeat containing 2 | 2.79506 |
| SMIM40 | small integral membrane protein 40 | 2.76356 |
| GPC1 | glypican 1 | 2.75576 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 2.75484 |
| TMEM50A | transmembrane protein 50A | 2.7395 |
| CTSL | cathepsin L | 2.737 |
| RRAGA | Ras-related GTP binding A | 2.71522 |
| PHKA1 | phosphorylase kinase, alpha 1 (muscle) | 2.69993 |
| BLCAP | bladder cancer associated protein | 2.674 |
| KLHL21 | kelch-like family member 21 | 2.6364 |
| SSH1 | slingshot protein phosphatase 1 | 2.62634 |
| PPARG | peroxisome proliferator-activated receptor gamma | 2.62395 |
| TAC4 | tachykinin 4 (hemokinin) | 2.61882 |
| TXNL4B | thioredoxin-like 4B | 2.58442 |
| ADGRG1 | adhesion G protein-coupled receptor G1 | 2.58255 |
| H2BC21 | H2B clustered histone 21 | 2.5784 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 2.56345 |
| ADI1 | acireductone dioxygenase 1 | 2.55247 |
| OSGIN1 | oxidative stress induced growth inhibitor 1 | 2.55194 |
| DCAF6 | DDB1 and CUL4 associated factor 6 | 2.47949 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | 2.44512 |
| RAB21 | RAB21, member RAS oncogene family | 2.44366 |
| CHN1 | chimerin 1 | 2.41734 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 2.38492 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 2.3531 |
| RAI14 | retinoic acid induced 14 | 2.33088 |
| DOK2 | docking protein 2, 56kDa | 2.30839 |
| RIC8B | RIC8 guanine nucleotide exchange factor B | 2.29859 |
| REEP5 | receptor accessory protein 5 | 2.26821 |
| PXMP2 | peroxisomal membrane protein 2, 22kDa | 2.2649 |
| CNPY3-GNMT | CNPY3-GNMT readthrough | 2.25435 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 2.24669 |
| HLA-DOB | major histocompatibility complex, class II, DO beta | 2.24511 |
| KLHDC3 | kelch domain containing 3 | 2.23394 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 2.22289 |
| SMN2 | survival of motor neuron 2, centromeric | 2.20955 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 2.20724 |
| NOCT | nocturnin | 2.18541 |
| LDLRAP1 | low density lipoprotein receptor adaptor protein 1 | 2.16342 |
| GARRE1 | granule associated Rac and RHOG effector 1 | 2.14857 |
| SP140 | SP140 nuclear body protein | 2.14132 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 2.13265 |
| ERP29 | endoplasmic reticulum protein 29 | 2.129 |
| CCP110 | centriolar coiled coil protein 110kDa | 2.12503 |
| ATP11B | ATPase, class VI, type 11B | 2.10367 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 2.10027 |
| GMNN | geminin, DNA replication inhibitor | 2.0983 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 2.07596 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 2.06792 |
| H2BC9 | H2B clustered histone 9 | 2.06419 |
| SOCS2 | suppressor of cytokine signaling 2 | 2.06328 |
| FRMPD1 | FERM and PDZ domain containing 1 | 2.05935 |
| BMP8B | bone morphogenetic protein 8b | 2.03142 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 2.02793 |
| PIR | pirin (iron-binding nuclear protein) | 2.02614 |
| SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | 2.02012 |
| TREM2 | triggering receptor expressed on myeloid cells 2 | 2.01714 |
| JMJD6 | jumonji domain containing 6 | 2.00805 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 2.00263 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PCNA | proliferating cell nuclear antigen | -10.0 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -7.34791 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -7.03664 |
| COG2 | component of oligomeric golgi complex 2 | -6.84135 |
| CCNB2 | cyclin B2 | -5.00826 |
| TLR4 | toll-like receptor 4 | -4.93082 |
| INTS3 | integrator complex subunit 3 | -4.81979 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -4.79988 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -4.7387 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -4.60339 |
| DCK | deoxycytidine kinase | -4.54079 |
| AKAP8 | A kinase (PRKA) anchor protein 8 | -4.2091 |
| GOLT1B | golgi transport 1B | -4.17795 |
| C2CD5 | C2 calcium-dependent domain containing 5 | -4.10132 |
| LDHD | lactate dehydrogenase D | -4.05224 |
| B4GAT1 | beta-1,4-glucuronyltransferase 1 | -3.96107 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | -3.93915 |
| CHMP4B | charged multivesicular body protein 4B | -3.93256 |
| CD320 | CD320 molecule | -3.8923 |
| HMGA2 | high mobility group AT-hook 2 | -3.86421 |
| SCAND1 | SCAN domain containing 1 | -3.75559 |
| TCEAL4 | transcription elongation factor A (SII)-like 4 | -3.75325 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | -3.71993 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -3.56424 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -3.49033 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -3.46918 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -3.3805 |
| PAFAH1B3 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) | -3.36932 |
| CCDC86 | coiled-coil domain containing 86 | -3.29565 |
| FGFR4 | fibroblast growth factor receptor 4 | -3.24467 |
| SPAG4 | sperm associated antigen 4 | -3.20839 |
| PGM1 | phosphoglucomutase 1 | -3.20035 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -3.15607 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -3.14353 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -3.03668 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -3.03437 |
| TLCD3A | TLC domain containing 3A | -3.02924 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | -3.0219 |
| DERA | deoxyribose-phosphate aldolase (putative) | -3.00302 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -2.96742 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -2.93043 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | -2.92327 |
| AGL | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | -2.90327 |
| HYOU1 | hypoxia up-regulated 1 | -2.90147 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | -2.87754 |
| NDUFA13 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 | -2.85323 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -2.82957 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -2.82103 |
| BLMH | bleomycin hydrolase | -2.81459 |
| TIMM10B | translocase of inner mitochondrial membrane 10 homolog B (yeast) | -2.75941 |
| MYLK | myosin light chain kinase | -2.73086 |
| DUSP6 | dual specificity phosphatase 6 | -2.7281 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | -2.71421 |
| STK25 | serine/threonine kinase 25 | -2.71061 |
| ACAA1 | acetyl-CoA acyltransferase 1 | -2.69871 |
| TMED10 | transmembrane emp24-like trafficking protein 10 (yeast) | -2.67695 |
| PRPF4 | pre-mRNA processing factor 4 | -2.66655 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | -2.5858 |
| DYNC2I1 | dynein 2 intermediate chain 1 | -2.56739 |
| CDK4 | cyclin-dependent kinase 4 | -2.5593 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -2.53806 |
| MAPK13 | mitogen-activated protein kinase 13 | -2.48557 |
| KANK1 | KN motif and ankyrin repeat domains 1 | -2.4645 |
| GNAS | GNAS complex locus | -2.45753 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | -2.42661 |
| ENOPH1 | enolase-phosphatase 1 | -2.41835 |
| NISCH | nischarin | -2.3947 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -2.35061 |
| ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta | -2.34135 |
| MRPS16 | mitochondrial ribosomal protein S16 | -2.3295 |
| MRTO4 | mRNA turnover 4 homolog (S. cerevisiae) | -2.32849 |
| NNT | nicotinamide nucleotide transhydrogenase | -2.32845 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | -2.32118 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | -2.31198 |
| LYZ | lysozyme | -2.2833 |
| MST1R | macrophage stimulating 1 receptor | -2.28127 |
| TSPAN4 | tetraspanin 4 | -2.27649 |
| DIXDC1 | DIX domain containing 1 | -2.27632 |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 | -2.25589 |
| DMAC2L | distal membrane arm assembly component 2 like | -2.24679 |
| MANSC1 | MANSC domain containing 1 | -2.23755 |
| CRTAP | cartilage associated protein | -2.22498 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | -2.20182 |
| INSIG2 | insulin induced gene 2 | -2.17833 |
| RAB11A | RAB11A, member RAS oncogene family | -2.14176 |
| PDZK1 | PDZ domain containing 1 | -2.13693 |
| MINDY1 | MINDY lysine 48 deubiquitinase 1 | -2.13154 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -2.1298 |
| NXT1 | nuclear transport factor 2-like export factor 1 | -2.10621 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -2.10557 |
| PYCR1 | pyrroline-5-carboxylate reductase 1 | -2.09063 |
| STXBP2 | syntaxin binding protein 2 | -2.07717 |
| PSME1 | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) | -2.07581 |
| CD151 | CD151 molecule (Raph blood group) | -2.06371 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -2.04002 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | -2.03118 |
| GET1 | guided entry of tail-anchored proteins factor 1 | -2.02536 |
| NDUFS5 | NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) | -2.02027 |
