| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | withaferin-a 0.62 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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97 genes differentially expressed following the CRCGN009_HEPG2_24H:G18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 6.56694 |
| ABHD4 | abhydrolase domain containing 4 | 5.62122 |
| UGDH | UDP-glucose 6-dehydrogenase | 5.2296 |
| MAP7 | microtubule-associated protein 7 | 4.93842 |
| SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | 4.62614 |
| HMOX1 | heme oxygenase 1 | 4.54847 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 4.20336 |
| HSPA1A | heat shock 70kDa protein 1A | 4.08248 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 3.72955 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 3.65298 |
| H2BC12 | H2B clustered histone 12 | 3.57227 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 3.54096 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 3.46307 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 3.46143 |
| CBR3 | carbonyl reductase 3 | 3.44709 |
| TMEM109 | transmembrane protein 109 | 3.33045 |
| FOSL1 | FOS-like antigen 1 | 3.32285 |
| LCN2 | lipocalin 2 | 3.31356 |
| RBKS | ribokinase | 3.25996 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 3.12202 |
| CCNA1 | cyclin A1 | 3.10327 |
| SQSTM1 | sequestosome 1 | 3.06626 |
| RRAGA | Ras-related GTP binding A | 2.97679 |
| KLHL21 | kelch-like family member 21 | 2.82379 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | 2.72968 |
| GTF2E2 | general transcription factor IIE, polypeptide 2, beta 34kDa | 2.64753 |
| PEX11A | peroxisomal biogenesis factor 11 alpha | 2.62391 |
| TERT | telomerase reverse transcriptase | 2.59735 |
| DIPK1A | divergent protein kinase domain 1A | 2.58387 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 2.58323 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 2.56581 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 2.51893 |
| DNTTIP2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | 2.51098 |
| RPS6KA1 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 2.50558 |
| CHMP6 | charged multivesicular body protein 6 | 2.47896 |
| BIRC2 | baculoviral IAP repeat containing 2 | 2.45461 |
| CYB561 | cytochrome b561 | 2.41423 |
| MAST2 | microtubule associated serine/threonine kinase 2 | 2.41332 |
| TEX10 | testis expressed 10 | 2.38475 |
| MCOLN1 | mucolipin 1 | 2.28868 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 2.28686 |
| KEAP1 | kelch-like ECH-associated protein 1 | 2.27781 |
| MYLK | myosin light chain kinase | 2.22617 |
| SLC35A1 | solute carrier family 35 (CMP-sialic acid transporter), member A1 | 2.22471 |
| PPARG | peroxisome proliferator-activated receptor gamma | 2.21717 |
| CCDC85B | coiled-coil domain containing 85B | 2.16751 |
| SMNDC1 | survival motor neuron domain containing 1 | 2.08481 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | 2.04646 |
| TATDN2 | TatD DNase domain containing 2 | 2.02657 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LDHD | lactate dehydrogenase D | -7.15124 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -5.68322 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -4.56757 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -4.24384 |
| HYOU1 | hypoxia up-regulated 1 | -4.11706 |
| TRIB3 | tribbles pseudokinase 3 | -3.96774 |
| HSPB1 | heat shock 27kDa protein 1 | -3.93759 |
| ANKRD10 | ankyrin repeat domain 10 | -3.93004 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -3.73322 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -3.6991 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -3.67402 |
| PGM1 | phosphoglucomutase 1 | -3.66607 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | -3.60267 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -3.55655 |
| MRPS2 | mitochondrial ribosomal protein S2 | -3.54187 |
| INTS3 | integrator complex subunit 3 | -3.35024 |
| COG2 | component of oligomeric golgi complex 2 | -3.20295 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -3.19878 |
| EGF | epidermal growth factor | -3.17839 |
| AKAP8 | A kinase (PRKA) anchor protein 8 | -2.90704 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | -2.87583 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -2.78771 |
| VAT1 | vesicle amine transport 1 | -2.69102 |
| CCNB2 | cyclin B2 | -2.61688 |
| GNAS | GNAS complex locus | -2.60439 |
| TCEAL4 | transcription elongation factor A (SII)-like 4 | -2.56813 |
| COL21A1 | collagen, type XXI, alpha 1 | -2.51769 |
| TMED10 | transmembrane emp24-like trafficking protein 10 (yeast) | -2.47141 |
| LSM6 | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.4641 |
| MTA1 | metastasis associated 1 | -2.46136 |
| TOR1A | torsin family 1, member A (torsin A) | -2.43625 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -2.42022 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -2.41105 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | -2.37343 |
| PAFAH1B3 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) | -2.32031 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -2.30828 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -2.25852 |
| C2CD5 | C2 calcium-dependent domain containing 5 | -2.22077 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.18482 |
| ADI1 | acireductone dioxygenase 1 | -2.18036 |
| ZNF274 | zinc finger protein 274 | -2.14349 |
| FGFR4 | fibroblast growth factor receptor 4 | -2.11801 |
| GET1 | guided entry of tail-anchored proteins factor 1 | -2.10453 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -2.07133 |
| ITIH5 | inter-alpha-trypsin inhibitor heavy chain family, member 5 | -2.03553 |
| ZNF586 | zinc finger protein 586 | -2.01687 |
| NDN | necdin, melanoma antigen (MAGE) family member | -2.01429 |
| MAPK13 | mitogen-activated protein kinase 13 | -2.00426 |
