CRCGN009_HEPG2_24H:G19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description diethyl 2-[(dimethoxyphosphoryl)sulfanyl]succinate 20.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

77 genes differentially expressed following the CRCGN009_HEPG2_24H:G19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 9.44584
LCN2 lipocalin 2 7.39249
GPER1 G protein-coupled estrogen receptor 1 5.26904
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 5.06993
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 4.93403
EPHB2 EPH receptor B2 4.8336
CHMP6 charged multivesicular body protein 6 4.32015
UBQLN2 ubiquilin 2 4.2593
LSR lipolysis stimulated lipoprotein receptor 4.23487
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.04074
MYLK myosin light chain kinase 3.88604
CYCS cytochrome c, somatic 3.8106
MAP7 microtubule-associated protein 7 3.80988
PEX11A peroxisomal biogenesis factor 11 alpha 3.74426
DIPK1A divergent protein kinase domain 1A 3.74155
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.54562
RAB11FIP2 RAB11 family interacting protein 2 (class I) 3.32801
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.19275
TBP TATA box binding protein 2.82893
GPATCH8 G patch domain containing 8 2.80869
RBKS ribokinase 2.76074
ZFP36 ZFP36 ring finger protein 2.71333
GDF2 growth differentiation factor 2 2.68125
FCHO1 FCH domain only 1 2.38975
SPTAN1 spectrin, alpha, non-erythrocytic 1 2.38202
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4 2.36204
PADI1 peptidyl arginine deiminase, type I 2.3058
IL5 interleukin 5 2.29889
TMEM212 transmembrane protein 212 2.29383
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.2689
IFT22 intraflagellar transport 22 2.23985
MYOD1 myogenic differentiation 1 2.2053
RPA3 replication protein A3, 14kDa 2.20077
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.19227
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.16292
NTF3 neurotrophin 3 2.15997
LRRC37A3 leucine rich repeat containing 37, member A3 2.14585
DOLPP1 dolichyldiphosphatase 1 2.12345
TAOK1 TAO kinase 1 2.12196
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 2.1214
TSEN2 TSEN2 tRNA splicing endonuclease subunit 2.09832
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 2.08471
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 2.06191
TMEM47 transmembrane protein 47 2.05514
CCL24 chemokine (C-C motif) ligand 24 2.05132
BORCS8 BLOC-1 related complex subunit 8 2.04254
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 2.03996
VRTN vertebrae development associated 2.02089
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 2.0067
PARD6A par-6 family cell polarity regulator alpha 2.00656
NPPA natriuretic peptide A 2.00349

decreased expression

Symbol Name Standardized Value
TARBP1 TAR (HIV-1) RNA binding protein 1 -10.0
LDHD lactate dehydrogenase D -5.21766
ZDHHC6 zinc finger, DHHC-type containing 6 -5.11233
EGF epidermal growth factor -4.65912
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.54075
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.51564
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.4578
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -4.39826
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -4.37005
FASTKD5 FAST kinase domains 5 -4.21297
NGRN neugrin, neurite outgrowth associated -4.15044
DNM1L dynamin 1-like -3.93955
RFC2 replication factor C (activator 1) 2, 40kDa -3.64793
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.58771
LOC124907782 dual specificity protein phosphatase 22 -2.9886
OXA1L oxidase (cytochrome c) assembly 1-like -2.92811
CCNB1 cyclin B1 -2.80674
ZMIZ1 zinc finger, MIZ-type containing 1 -2.72302
NUP62 nucleoporin 62kDa -2.67705
IFRD2 interferon-related developmental regulator 2 -2.55841
TRPM4 transient receptor potential cation channel, subfamily M, member 4 -2.33174
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 -2.29109
RYR1 ryanodine receptor 1 (skeletal) -2.19134
PDZD2 PDZ domain containing 2 -2.09376
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.07168
NRIP1 nuclear receptor interacting protein 1 -2.00288