CRCGN009_HEPG2_24H:G20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description diethyl 2-[(dimethoxyphosphoryl)sulfanyl]succinate 10.12 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

47 genes differentially expressed following the CRCGN009_HEPG2_24H:G20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GATA3 GATA binding protein 3 5.35218
LCN2 lipocalin 2 5.14088
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.99777
CIAO3 cytosolic iron-sulfur assembly component 3 4.82277
NOTCH1 notch 1 4.67907
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.6251
PPARG peroxisome proliferator-activated receptor gamma 4.55494
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 4.54526
EPHA3 EPH receptor A3 3.71917
MAP7 microtubule-associated protein 7 3.66562
LOC122526780 uncharacterized LOC122526780 3.61391
INTS3 integrator complex subunit 3 3.39672
CYCS cytochrome c, somatic 3.26414
TEX10 testis expressed 10 2.90421
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.85191
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.83178
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.77154
CRK v-crk avian sarcoma virus CT10 oncogene homolog 2.69623
SNAP25 synaptosomal-associated protein, 25kDa 2.62152
GPER1 G protein-coupled estrogen receptor 1 2.33113
ADGRG1 adhesion G protein-coupled receptor G1 2.31901
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.25841
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.23951
TULP4 tubby like protein 4 2.22515
FAM168B family with sequence similarity 168, member B 2.12066
ANKFY1 ankyrin repeat and FYVE domain containing 1 2.08049
EIF4A1 eukaryotic translation initiation factor 4A1 2.07862
HNRNPF heterogeneous nuclear ribonucleoprotein F 2.06517
TMEM260 transmembrane protein 260 2.04522

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -8.5126
CCNB2 cyclin B2 -7.60876
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.67822
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -4.79433
LOC124907782 dual specificity protein phosphatase 22 -3.8589
OXA1L oxidase (cytochrome c) assembly 1-like -3.51881
RAI14 retinoic acid induced 14 -3.23306
ILK integrin-linked kinase -3.17476
NUP93 nucleoporin 93kDa -3.1375
SNX11 sorting nexin 11 -3.12088
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.98494
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.88222
HMG20B high mobility group 20B -2.62629
RGS2 regulator of G-protein signaling 2 -2.56256
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.4501
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor -2.3097
ARL2BP ADP-ribosylation factor-like 2 binding protein -2.16513
SSBP2 single-stranded DNA binding protein 2 -2.0961