| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | diethyl 2-[(dimethoxyphosphoryl)sulfanyl]succinate 2.53 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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78 genes differentially expressed following the CRCGN009_HEPG2_24H:G22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 10.0 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 9.61242 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 7.5546 |
| MCOLN1 | mucolipin 1 | 5.24031 |
| UBQLN2 | ubiquilin 2 | 5.11805 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 5.08643 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 4.80353 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 4.80195 |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | 4.69962 |
| STAP2 | signal transducing adaptor family member 2 | 4.64316 |
| MYLK | myosin light chain kinase | 4.63866 |
| PPARG | peroxisome proliferator-activated receptor gamma | 4.43366 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 4.34688 |
| AGL | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | 4.30241 |
| PRR15L | proline rich 15-like | 4.16648 |
| NOSIP | nitric oxide synthase interacting protein | 3.85293 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 3.32524 |
| FZD7 | frizzled class receptor 7 | 3.26689 |
| ICAM1 | intercellular adhesion molecule 1 | 3.04508 |
| HEBP1 | heme binding protein 1 | 2.8479 |
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 2.58456 |
| TBC1D31 | TBC1 domain family, member 31 | 2.52786 |
| JADE2 | jade family PHD finger 2 | 2.45861 |
| LPAR2 | lysophosphatidic acid receptor 2 | 2.44701 |
| TESK1 | testis-specific kinase 1 | 2.44688 |
| GSTZ1 | glutathione S-transferase zeta 1 | 2.44439 |
| GDPD5 | glycerophosphodiester phosphodiesterase domain containing 5 | 2.37938 |
| CHN1 | chimerin 1 | 2.3693 |
| PNPLA6 | patatin-like phospholipase domain containing 6 | 2.32279 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 2.29319 |
| PTK2 | protein tyrosine kinase 2 | 2.22378 |
| OSMR | oncostatin M receptor | 2.18165 |
| GABPA | GA binding protein transcription factor, alpha subunit 60kDa | 2.12468 |
| DIPK1A | divergent protein kinase domain 1A | 2.10701 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 2.10642 |
| BAX | BCL2-associated X protein | 2.08867 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 2.06336 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 2.05326 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 2.05116 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 2.03477 |
| IL1B | interleukin 1, beta | 2.03433 |
| MBNL2 | muscleblind-like splicing regulator 2 | 2.00374 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -5.25978 |
| NRIP1 | nuclear receptor interacting protein 1 | -5.13196 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | -5.0721 |
| MRPS2 | mitochondrial ribosomal protein S2 | -5.0258 |
| CDC25B | cell division cycle 25B | -4.9723 |
| LDHD | lactate dehydrogenase D | -4.72771 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -4.71363 |
| DNM1L | dynamin 1-like | -4.64634 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -4.64399 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -4.60672 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -4.56593 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -4.46983 |
| ADI1 | acireductone dioxygenase 1 | -4.06472 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -3.93412 |
| SNX11 | sorting nexin 11 | -3.73267 |
| HEATR1 | HEAT repeat containing 1 | -3.71119 |
| TOR1A | torsin family 1, member A (torsin A) | -3.58568 |
| CCNB2 | cyclin B2 | -3.55536 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | -3.29933 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -3.28003 |
| CCNH | cyclin H | -2.93564 |
| TWF2 | twinfilin actin binding protein 2 | -2.71212 |
| DDIT4 | DNA-damage-inducible transcript 4 | -2.62264 |
| BIRC2 | baculoviral IAP repeat containing 2 | -2.6068 |
| EIF5 | eukaryotic translation initiation factor 5 | -2.45634 |
| TBC1D13 | TBC1 domain family, member 13 | -2.40085 |
| WASHC4 | WASH complex subunit 4 | -2.33347 |
| PSMB10 | proteasome (prosome, macropain) subunit, beta type, 10 | -2.2567 |
| MAPK13 | mitogen-activated protein kinase 13 | -2.25539 |
| SPECC1L | sperm antigen with calponin homology and coiled-coil domains 1-like | -2.13154 |
| LGALSL | lectin, galactoside-binding-like | -2.12785 |
| STMN1 | stathmin 1 | -2.12106 |
| PSMD1 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | -2.07813 |
| ILK | integrin-linked kinase | -2.04305 |
| LGMN | legumain | -2.03601 |
| PPM1A | protein phosphatase, Mg2+/Mn2+ dependent, 1A | -2.00838 |
