CRCGN009_HEPG2_24H:G24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description diethyl 2-[(dimethoxyphosphoryl)sulfanyl]succinate 0.63 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

51 genes differentially expressed following the CRCGN009_HEPG2_24H:G24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HLA-DMA major histocompatibility complex, class II, DM alpha 4.99581
PPARG peroxisome proliferator-activated receptor gamma 4.54043
UBQLN2 ubiquilin 2 4.51221
DYNLT3 dynein, light chain, Tctex-type 3 4.50201
CIAO3 cytosolic iron-sulfur assembly component 3 4.43975
SNAP25 synaptosomal-associated protein, 25kDa 4.20973
CYCS cytochrome c, somatic 4.20795
HLA-DRA major histocompatibility complex, class II, DR alpha 3.90303
MAP7 microtubule-associated protein 7 3.32063
GATA2 GATA binding protein 2 3.2212
TIAM1 T-cell lymphoma invasion and metastasis 1 3.18741
LCN2 lipocalin 2 3.14346
GPER1 G protein-coupled estrogen receptor 1 3.11712
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.8711
NOSIP nitric oxide synthase interacting protein 2.61706
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.50131
CHN1 chimerin 1 2.41198
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast) 2.39386
TATDN2 TatD DNase domain containing 2 2.30244
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.28733
XK X-linked Kx blood group 2.25629
DIPK1A divergent protein kinase domain 1A 2.13654
BTN3A2 butyrophilin, subfamily 3, member A2 2.03746
PCDHB11 protocadherin beta 11 2.02053

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -7.124
PEG10 paternally expressed 10 -5.33163
TRIB3 tribbles pseudokinase 3 -5.18198
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.19326
DNM1L dynamin 1-like -4.16211
FBXL12 F-box and leucine-rich repeat protein 12 -4.15531
PCNA proliferating cell nuclear antigen -4.09437
CCNB2 cyclin B2 -3.77476
FGFR4 fibroblast growth factor receptor 4 -3.51656
EGF epidermal growth factor -3.39234
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.2782
HYOU1 hypoxia up-regulated 1 -3.20779
ZNF586 zinc finger protein 586 -3.07085
CPNE3 copine III -3.03536
CTNND1 catenin (cadherin-associated protein), delta 1 -2.88421
EIF5 eukaryotic translation initiation factor 5 -2.79935
NRIP1 nuclear receptor interacting protein 1 -2.28629
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 -2.17808
STUM stum, mechanosensory transduction mediator homolog -2.05988
SPIB Spi-B transcription factor (Spi-1/PU.1 related) -2.04421
RND1 Rho family GTPase 1 -2.0403
CLSTN3 calsyntenin 3 -2.0317
MAGEA9B melanoma antigen family A9B -2.02985
CSRNP2 cysteine-serine-rich nuclear protein 2 -2.02175
BAZ2B bromodomain adjacent to zinc finger domain, 2B -2.01983
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -2.01508
FGB fibrinogen beta chain -2.00361