CRCGN009_HEPG2_24H:H05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hexachlorophene 2.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

279 genes differentially expressed following the CRCGN009_HEPG2_24H:H05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 10.0
ALDOC aldolase C, fructose-bisphosphate 8.60329
FHL2 four and a half LIM domains 2 7.54011
CYCS cytochrome c, somatic 7.02628
LCN2 lipocalin 2 6.59213
PPARG peroxisome proliferator-activated receptor gamma 6.09358
DDIT4 DNA-damage-inducible transcript 4 5.84581
TRIB3 tribbles pseudokinase 3 5.56871
TIMP2 TIMP metallopeptidase inhibitor 2 5.53851
INPP1 inositol polyphosphate-1-phosphatase 5.53403
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 5.2622
GFPT1 glutamine--fructose-6-phosphate transaminase 1 5.03967
CCDC92 coiled-coil domain containing 92 4.83898
ZFP36 ZFP36 ring finger protein 4.65578
CTSL cathepsin L 4.46542
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 4.3417
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 4.32434
ADO 2-aminoethanethiol (cysteamine) dioxygenase 4.32263
IGFBP3 insulin-like growth factor binding protein 3 4.30108
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 4.28863
EGR1 early growth response 1 4.20371
VAT1 vesicle amine transport 1 4.00873
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 3.93921
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.87926
SHB Src homology 2 domain containing adaptor protein B 3.66165
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 3.62509
KDM3A lysine (K)-specific demethylase 3A 3.61277
NPC1 Niemann-Pick disease, type C1 3.58491
GARS1 glycyl-tRNA synthetase 1 3.30975
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 3.27555
JADE2 jade family PHD finger 2 3.24547
EPHA3 EPH receptor A3 3.20106
ABHD6 abhydrolase domain containing 6 3.19623
AARS1 alanyl-tRNA synthetase 1 3.1752
MBNL2 muscleblind-like splicing regulator 2 3.15869
ANO1 anoctamin 1, calcium activated chloride channel 3.15521
TXNRD1 thioredoxin reductase 1 3.13337
KIFBP kinesin family binding protein 3.12645
RAP1GAP RAP1 GTPase activating protein 3.07413
STAP2 signal transducing adaptor family member 2 3.0339
LRP10 low density lipoprotein receptor-related protein 10 3.02568
SQSTM1 sequestosome 1 3.0228
TM9SF2 transmembrane 9 superfamily member 2 3.00916
ITGB5 integrin, beta 5 3.00303
DIPK1A divergent protein kinase domain 1A 3.00265
CNPY3 canopy FGF signaling regulator 3 2.98822
NFIL3 nuclear factor, interleukin 3 regulated 2.98266
MTERF3 mitochondrial transcription termination factor 3 2.98057
DUSP6 dual specificity phosphatase 6 2.94374
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 2.93994
GRB10 growth factor receptor-bound protein 10 2.87762
HLA-DMA major histocompatibility complex, class II, DM alpha 2.81772
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.81544
GLRX glutaredoxin (thioltransferase) 2.80953
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.80227
GTPBP2 GTP binding protein 2 2.67752
FOXO4 forkhead box O4 2.66256
NIPSNAP1 nipsnap homolog 1 (C. elegans) 2.62691
CHMP6 charged multivesicular body protein 6 2.6267
MMUT methylmalonyl-CoA mutase 2.61939
MVP major vault protein 2.58919
IER3 immediate early response 3 2.57468
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.57265
MYO1D myosin ID 2.52714
AXIN1 axin 1 2.46792
RBM41 RNA binding motif protein 41 2.4534
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) 2.39705
TNIP1 TNFAIP3 interacting protein 1 2.38316
CISD1 CDGSH iron sulfur domain 1 2.37541
IL4R interleukin 4 receptor 2.37018
ABHD4 abhydrolase domain containing 4 2.36204
TMEM140 transmembrane protein 140 2.33971
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) 2.3216
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 2.30329
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 2.28556
MICALL2 MICAL-like 2 2.28143
ACOT9 acyl-CoA thioesterase 9 2.28053
TBP TATA box binding protein 2.25651
GPATCH8 G patch domain containing 8 2.24079
MAP7 microtubule-associated protein 7 2.23174
TMEM184B transmembrane protein 184B 2.20898
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 2.20406
PTK2 protein tyrosine kinase 2 2.19671
NANOS3 nanos homolog 3 (Drosophila) 2.18988
ACAD10 acyl-CoA dehydrogenase family, member 10 2.18456
USP6NL USP6 N-terminal like 2.16973
PDE8A phosphodiesterase 8A 2.15961
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1 2.15915
SLC67A1 solute carrier family 67 member 1 2.14733
DUSP3 dual specificity phosphatase 3 2.13863
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.13476
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.12841
ZMIZ1 zinc finger, MIZ-type containing 1 2.12222
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) 2.11552
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2.1051
TARS1 threonyl-tRNA synthetase 1 2.10121
OXR1 oxidation resistance 1 2.09934
HOOK1 hook microtubule-tethering protein 1 2.09627
WDR13 WD repeat domain 13 2.07594
ATG9A autophagy related 9A 2.06656
FAM200C family with sequence similarity 200 member C 2.06183
GPKOW G patch domain and KOW motifs 2.06053
SKIC2 SKI2 subunit of superkiller complex 2.05861
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 2.05519
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 2.03942
BABAM2 BRISC and BRCA1 A complex member 2 2.03726
AHR aryl hydrocarbon receptor 2.02802
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 2.0251
RGL2 ral guanine nucleotide dissociation stimulator-like 2 2.01576
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha 2.01322
KIFC3 kinesin family member C3 2.0114

decreased expression

Symbol Name Standardized Value
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -8.27821
ISOC1 isochorismatase domain containing 1 -7.42911
HSPB1 heat shock 27kDa protein 1 -7.29315
CCNB1 cyclin B1 -7.05362
CDC20 cell division cycle 20 -6.87624
MELK maternal embryonic leucine zipper kinase -6.86511
RFC2 replication factor C (activator 1) 2, 40kDa -6.48627
STMN1 stathmin 1 -6.17691
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -5.85766
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -5.5643
PSRC1 proline/serine-rich coiled-coil 1 -5.52935
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -5.50583
CDK1 cyclin-dependent kinase 1 -5.17276
TOP2A topoisomerase (DNA) II alpha 170kDa -5.16901
BIRC5 baculoviral IAP repeat containing 5 -5.11062
PLK1 polo-like kinase 1 -5.0092
CCNA2 cyclin A2 -4.98945
AURKB aurora kinase B -4.95918
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -4.70484
PCNA proliferating cell nuclear antigen -4.67204
SLC35F2 solute carrier family 35, member F2 -4.6153
CHEK1 checkpoint kinase 1 -4.60469
RPIA ribose 5-phosphate isomerase A -4.55776
GTF2A2 general transcription factor IIA, 2, 12kDa -4.53007
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -4.50273
POLR1A polymerase (RNA) I polypeptide A, 194kDa -4.2317
UBE2C ubiquitin-conjugating enzyme E2C -4.02563
FAIM Fas apoptotic inhibitory molecule -3.94699
NUP85 nucleoporin 85kDa -3.93704
HYOU1 hypoxia up-regulated 1 -3.87625
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.86028
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.83094
ASF1B anti-silencing function 1B histone chaperone -3.73732
TOR1A torsin family 1, member A (torsin A) -3.66008
NLRP2B NLR family pyrin domain containing 2B -3.59523
RNASE7 ribonuclease, RNase A family, 7 -3.52514
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.46029
HAT1 histone acetyltransferase 1 -3.41403
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.4121
PEG10 paternally expressed 10 -3.40644
CCDC86 coiled-coil domain containing 86 -3.33648
GINS2 GINS complex subunit 2 (Psf2 homolog) -3.32367
CDC25B cell division cycle 25B -3.32185
PARP1 poly (ADP-ribose) polymerase 1 -3.30074
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -3.25298
TSEN2 TSEN2 tRNA splicing endonuclease subunit -3.21877
CDCA8 cell division cycle associated 8 -3.18254
TK1 thymidine kinase 1, soluble -3.14001
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.10139
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.07059
TMEM109 transmembrane protein 109 -3.06346
MSH6 mutS homolog 6 -3.05703
CENPX centromere protein X -3.01878
ZNF274 zinc finger protein 274 -3.01799
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.99823
LBR lamin B receptor -2.99304
OIP5 Opa interacting protein 5 -2.98539
MCM10 minichromosome maintenance complex component 10 -2.97375
MYCBP MYC binding protein -2.973
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.9466
DSCC1 DNA replication and sister chromatid cohesion 1 -2.94655
GLOD4 glyoxalase domain containing 4 -2.92516
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.91464
THAP11 THAP domain containing 11 -2.91219
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -2.90228
CDCA3 cell division cycle associated 3 -2.86729
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.86226
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.84404
FZD7 frizzled class receptor 7 -2.84101
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -2.82548
ANAPC15 anaphase promoting complex subunit 15 -2.793
DCK deoxycytidine kinase -2.77482
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.76617
VDAC1 voltage-dependent anion channel 1 -2.76222
PPIC peptidylprolyl isomerase C (cyclophilin C) -2.76129
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.74047
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.73612
NUP62 nucleoporin 62kDa -2.73025
TIPIN TIMELESS interacting protein -2.70799
CDPF1 cysteine-rich, DPF motif domain containing 1 -2.70075
MRPL39 mitochondrial ribosomal protein L39 -2.67563
WRAP53 WD repeat containing, antisense to TP53 -2.67301
MRTO4 mRNA turnover 4 homolog (S. cerevisiae) -2.65834
PAGR1 PAXIP1 associated glutamate-rich protein 1 -2.6433
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.63043
PXMP2 peroxisomal membrane protein 2, 22kDa -2.62857
KIF11 kinesin family member 11 -2.62468
ERCC6L excision repair cross-complementation group 6-like -2.61329
CKS1B CDC28 protein kinase regulatory subunit 1B -2.60567
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2 -2.58147
ELAC2 elaC ribonuclease Z 2 -2.57648
CDKN3 cyclin-dependent kinase inhibitor 3 -2.57181
DBF4 DBF4 zinc finger -2.53316
GMNN geminin, DNA replication inhibitor -2.51864
CD320 CD320 molecule -2.51746
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.51097
ADI1 acireductone dioxygenase 1 -2.51058
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.4998
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 -2.49545
DERA deoxyribose-phosphate aldolase (putative) -2.47144
GEMIN6 gem (nuclear organelle) associated protein 6 -2.46137
TATDN2 TatD DNase domain containing 2 -2.45695
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -2.45225
ERH enhancer of rudimentary homolog (Drosophila) -2.45121
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -2.44436
SNRPF small nuclear ribonucleoprotein polypeptide F -2.43885
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.43371
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.42357
VRK1 vaccinia related kinase 1 -2.41924
BANF1 barrier to autointegration factor 1 -2.4058
CDC6 cell division cycle 6 -2.40389
MRPL12 mitochondrial ribosomal protein L12 -2.39799
TEDC2 tubulin epsilon and delta complex 2 -2.39183
MIS18A MIS18 kinetochore protein A -2.38266
RFC5 replication factor C (activator 1) 5, 36.5kDa -2.37494
ZNF107 zinc finger protein 107 -2.36135
CCND3 cyclin D3 -2.29312
ZDHHC6 zinc finger, DHHC-type containing 6 -2.29206
TFDP1 transcription factor Dp-1 -2.28154
CSK c-src tyrosine kinase -2.27494
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -2.27285
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.27175
DUT deoxyuridine triphosphatase -2.2511
CDC25A cell division cycle 25A -2.24131
PRPF4 pre-mRNA processing factor 4 -2.23701
PDIA6 protein disulfide isomerase family A, member 6 -2.21592
TP53RK TP53 regulating kinase -2.20249
FANCI Fanconi anemia, complementation group I -2.19807
HSPA14 heat shock 70kDa protein 14 -2.19639
LMNB1 lamin B1 -2.19077
CERS1 ceramide synthase 1 -2.18504
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha -2.18206
SESN1 sestrin 1 -2.18095
CSF3 colony stimulating factor 3 (granulocyte) -2.17345
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.17219
CENPM centromere protein M -2.15441
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) -2.14654
ENY2 enhancer of yellow 2 homolog (Drosophila) -2.1462
LAGE3 L antigen family, member 3 -2.14363
SLC35B1 solute carrier family 35, member B1 -2.14155
RPP38 ribonuclease P/MRP 38kDa subunit -2.13963
PSMC3IP PSMC3 interacting protein -2.13178
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.1312
EED embryonic ectoderm development -2.12308
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) -2.11431
FBXL12 F-box and leucine-rich repeat protein 12 -2.11231
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -2.10816
PPIH peptidylprolyl isomerase H (cyclophilin H) -2.09094
RAD54L RAD54-like (S. cerevisiae) -2.09093
FBXO5 F-box protein 5 -2.09062
RFC3 replication factor C (activator 1) 3, 38kDa -2.08982
CHAF1A chromatin assembly factor 1, subunit A (p150) -2.06775
NENF neudesin neurotrophic factor -2.06464
TCERG1 transcription elongation regulator 1 -2.06273
SRSF3 serine/arginine-rich splicing factor 3 -2.06055
SPDL1 spindle apparatus coiled-coil protein 1 -2.05406
DEPDC1 DEP domain containing 1 -2.05061
CHAF1B chromatin assembly factor 1, subunit B (p60) -2.04761
SPOUT1 SPOUT domain containing methyltransferase 1 -2.04056
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 -2.03579
ZWINT ZW10 interacting kinetochore protein -2.02966
ARF5 ADP-ribosylation factor 5 -2.02165
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 -2.02054
CNTFR ciliary neurotrophic factor receptor -2.01713
SPC25 SPC25, NDC80 kinetochore complex component -2.01708
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) -2.01448
FEN1 flap structure-specific endonuclease 1 -2.00903
EMC9 ER membrane protein complex subunit 9 -2.00792