CRCGN009_HEPG2_24H:H06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hexachlorophene 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

83 genes differentially expressed following the CRCGN009_HEPG2_24H:H06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 10.0
EVL Enah/Vasp-like 6.90813
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 6.8114
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.74797
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 5.34937
MAP7 microtubule-associated protein 7 5.25551
ABHD6 abhydrolase domain containing 6 5.23274
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.53583
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.46735
CNPY3 canopy FGF signaling regulator 3 4.38262
GPER1 G protein-coupled estrogen receptor 1 4.16594
HLA-DMA major histocompatibility complex, class II, DM alpha 4.1129
SFTPB surfactant protein B 3.66123
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 3.61764
ALDOC aldolase C, fructose-bisphosphate 3.57132
GSTZ1 glutathione S-transferase zeta 1 3.56092
E2F2 E2F transcription factor 2 3.54758
CARMIL1 capping protein regulator and myosin 1 linker 1 3.4294
CHN1 chimerin 1 3.3091
DDIT4 DNA-damage-inducible transcript 4 3.24032
MOK MOK protein kinase 3.21225
C2CD2 C2 calcium-dependent domain containing 2 3.17345
PYCR1 pyrroline-5-carboxylate reductase 1 3.14339
ADGRE5 adhesion G protein-coupled receptor E5 2.98113
PEX11A peroxisomal biogenesis factor 11 alpha 2.86079
TRIB3 tribbles pseudokinase 3 2.80106
CEMIP2 cell migration inducing hyaluronidase 2 2.77718
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.76186
MINDY1 MINDY lysine 48 deubiquitinase 1 2.68162
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.66569
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.59658
ATP11B ATPase, class VI, type 11B 2.55082
GOLT1B golgi transport 1B 2.54183
HLA-DRA major histocompatibility complex, class II, DR alpha 2.42879
TIAM1 T-cell lymphoma invasion and metastasis 1 2.39204
STIMATE STIM activating enhancer 2.31609
MX1 MX dynamin-like GTPase 1 2.24141
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.21501
CD40 CD40 molecule, TNF receptor superfamily member 5 2.19077
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 2.15713
INPP1 inositol polyphosphate-1-phosphatase 2.1489
JADE2 jade family PHD finger 2 2.13784
LPAR2 lysophosphatidic acid receptor 2 2.13638
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.11955
TMED3 transmembrane emp24 protein transport domain containing 3 2.10806
PGM1 phosphoglucomutase 1 2.08116
GRWD1 glutamate-rich WD repeat containing 1 2.05729
USP6NL USP6 N-terminal like 2.04867
SATB1 SATB homeobox 1 2.04046
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.02638
RSAD2 radical S-adenosyl methionine domain containing 2 2.00709

decreased expression

Symbol Name Standardized Value
TLR4 toll-like receptor 4 -7.79876
PCNA proliferating cell nuclear antigen -6.80447
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.97834
SLC35F2 solute carrier family 35, member F2 -4.96004
ZNF586 zinc finger protein 586 -4.81022
ADI1 acireductone dioxygenase 1 -4.08152
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.00172
RNF167 ring finger protein 167 -3.68322
THAP11 THAP domain containing 11 -3.66791
TLCD3A TLC domain containing 3A -3.65204
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.55367
COG4 component of oligomeric golgi complex 4 -3.45919
LAP3 leucine aminopeptidase 3 -3.28731
CHMP4B charged multivesicular body protein 4B -3.21642
LDHD lactate dehydrogenase D -3.12786
NCK1 NCK adaptor protein 1 -3.03986
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.88087
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.71992
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.70948
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.68492
ZMIZ1 zinc finger, MIZ-type containing 1 -2.61036
VAT1 vesicle amine transport 1 -2.49108
NCK2 NCK adaptor protein 2 -2.41342
TUBB6 tubulin, beta 6 class V -2.27225
KDM3A lysine (K)-specific demethylase 3A -2.25136
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.23783
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.17204
LIAS lipoic acid synthetase -2.15946
RPIA ribose 5-phosphate isomerase A -2.15345
DAZ2 deleted in azoospermia 2 -2.15011
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.13374
TRIB2 tribbles pseudokinase 2 -2.10523