CRCGN009_HEPG2_24H:H07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description diphenhydramine 40.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

72 genes differentially expressed following the CRCGN009_HEPG2_24H:H07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 7.2525
AMDHD2 amidohydrolase domain containing 2 6.99459
MAP7 microtubule-associated protein 7 6.01192
PPARG peroxisome proliferator-activated receptor gamma 5.5888
RPP38 ribonuclease P/MRP 38kDa subunit 5.29121
MAMLD1 mastermind-like domain containing 1 5.10874
EPHB2 EPH receptor B2 4.47275
DYNLT3 dynein, light chain, Tctex-type 3 4.25185
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.50335
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.21777
LCN2 lipocalin 2 3.18817
ADRB2 adrenoceptor beta 2, surface 3.10667
ICAM1 intercellular adhesion molecule 1 3.06332
CYCS cytochrome c, somatic 3.0628
CORO1A coronin, actin binding protein, 1A 3.00662
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.89135
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.71351
IDE insulin-degrading enzyme 2.69201
SCRN1 secernin 1 2.63815
HLA-DRA major histocompatibility complex, class II, DR alpha 2.47872
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.4681
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.45816
TSPAN6 tetraspanin 6 2.44957
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.43705
IFI44L interferon-induced protein 44-like 2.37033
KIF20A kinesin family member 20A 2.36598
GPER1 G protein-coupled estrogen receptor 1 2.30175
ABHD6 abhydrolase domain containing 6 2.28793
IFI44 interferon-induced protein 44 2.27534
CNPY3 canopy FGF signaling regulator 3 2.2557
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.23504
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.21886
CD40 CD40 molecule, TNF receptor superfamily member 5 2.19649
GALE UDP-galactose-4-epimerase 2.11402
ZFP36 ZFP36 ring finger protein 2.09766
NUP133 nucleoporin 133kDa 2.07952
CARMIL1 capping protein regulator and myosin 1 linker 1 2.05212
CDC45 cell division cycle 45 2.04066
NPY4R2 neuropeptide Y receptor Y4-2 2.01904
SUCO SUN domain containing ossification factor 2.01819
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.0063
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 2.00107

decreased expression

Symbol Name Standardized Value
MAPK13 mitogen-activated protein kinase 13 -4.37059
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.10351
CHMP4B charged multivesicular body protein 4B -3.95024
FASTKD5 FAST kinase domains 5 -3.92516
ZMIZ1 zinc finger, MIZ-type containing 1 -3.89057
CDC25B cell division cycle 25B -3.86224
CCNB2 cyclin B2 -3.79236
NGRN neugrin, neurite outgrowth associated -3.62203
CDC20 cell division cycle 20 -3.5071
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.32752
LOC124907782 dual specificity protein phosphatase 22 -3.25771
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.12137
FHL2 four and a half LIM domains 2 -2.98052
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.96715
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.8918
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.8899
GOLT1B golgi transport 1B -2.7684
ZNF586 zinc finger protein 586 -2.61102
DCK deoxycytidine kinase -2.52976
CHIC2 cysteine-rich hydrophobic domain 2 -2.52253
LDHD lactate dehydrogenase D -2.50364
SLC35F2 solute carrier family 35, member F2 -2.495
ADI1 acireductone dioxygenase 1 -2.42877
TOMM70 translocase of outer mitochondrial membrane 70 -2.28761
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.27618
UBE3C ubiquitin protein ligase E3C -2.26323
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.2037
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.1873
CD58 CD58 molecule -2.18322
YME1L1 YME1-like 1 ATPase -2.05807