CRCGN009_HEPG2_24H:H09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description diphenhydramine 10.05 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

44 genes differentially expressed following the CRCGN009_HEPG2_24H:H09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.53672
CGRRF1 cell growth regulator with ring finger domain 1 3.72481
CARMIL1 capping protein regulator and myosin 1 linker 1 3.67296
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.97493
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.86782
GPATCH8 G patch domain containing 8 2.6452
GPER1 G protein-coupled estrogen receptor 1 2.62933
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.61256
ADRB2 adrenoceptor beta 2, surface 2.57709
E2F2 E2F transcription factor 2 2.5569
CEP57 centrosomal protein 57kDa 2.49828
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.48779
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.36578
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.33588
H2BC12 H2B clustered histone 12 2.2636
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.17539
MKS1 Meckel syndrome, type 1 2.16098
ZKSCAN3 zinc finger with KRAB and SCAN domains 3 2.11113
ABHD6 abhydrolase domain containing 6 2.10808
STIMATE STIM activating enhancer 2.09948
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.0132

decreased expression

Symbol Name Standardized Value
GOLT1B golgi transport 1B -7.70679
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -5.20258
TRAP1 TNF receptor-associated protein 1 -5.06763
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.79753
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -4.71948
TUBB6 tubulin, beta 6 class V -4.70524
PCNA proliferating cell nuclear antigen -4.42665
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -3.70915
FHL2 four and a half LIM domains 2 -2.92497
DNM1L dynamin 1-like -2.88149
LDHD lactate dehydrogenase D -2.41748
ZNF586 zinc finger protein 586 -2.40442
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.40337
PEG10 paternally expressed 10 -2.40295
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.31257
MED21 mediator complex subunit 21 -2.27516
ISOC1 isochorismatase domain containing 1 -2.24449
ACAA1 acetyl-CoA acyltransferase 1 -2.2093
RNF167 ring finger protein 167 -2.1722
RECQL RecQ helicase-like -2.15464
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.13057
TXNDC9 thioredoxin domain containing 9 -2.10303
CRYAB crystallin, alpha B -2.08316