CRCGN009_HEPG2_24H:H11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description diphenhydramine 2.51 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

44 genes differentially expressed following the CRCGN009_HEPG2_24H:H11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 8.27709
ATP11B ATPase, class VI, type 11B 5.3836
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.28629
LCN2 lipocalin 2 4.79332
KDM5A lysine (K)-specific demethylase 5A 4.34231
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.94388
MAP7 microtubule-associated protein 7 3.53917
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.45173
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.3903
JADE2 jade family PHD finger 2 3.34549
CCNF cyclin F 3.31001
GPER1 G protein-coupled estrogen receptor 1 3.06211
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.958
SFTPB surfactant protein B 2.94658
GPATCH8 G patch domain containing 8 2.8486
NOSIP nitric oxide synthase interacting protein 2.71743
CDC45 cell division cycle 45 2.358
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.34238
IQGAP1 IQ motif containing GTPase activating protein 1 2.33354
KIF20A kinesin family member 20A 2.29298
MCOLN1 mucolipin 1 2.20873
GSTZ1 glutathione S-transferase zeta 1 2.19026
CIDEB cell death-inducing DFFA-like effector b 2.07753
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.01961

decreased expression

Symbol Name Standardized Value
KDM3A lysine (K)-specific demethylase 3A -5.91779
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.65543
CCNB2 cyclin B2 -4.0305
CDC20 cell division cycle 20 -3.64759
C2CD5 C2 calcium-dependent domain containing 5 -3.38373
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.28826
MRPS16 mitochondrial ribosomal protein S16 -3.15266
ZDHHC6 zinc finger, DHHC-type containing 6 -3.08314
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.91297
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.82345
GNAS GNAS complex locus -2.70473
RNF167 ring finger protein 167 -2.3184
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -2.31082
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.24413
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.23784
SPAG4 sperm associated antigen 4 -2.15778
EGF epidermal growth factor -2.1183
SESN1 sestrin 1 -2.1012
BIRC2 baculoviral IAP repeat containing 2 -2.02727
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.01812