CRCGN009_HEPG2_24H:H19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tegafur 20.82 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

38 genes differentially expressed following the CRCGN009_HEPG2_24H:H19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NOTCH1 notch 1 5.02104
STIMATE STIM activating enhancer 4.6068
CXCL2 chemokine (C-X-C motif) ligand 2 4.56392
PPARG peroxisome proliferator-activated receptor gamma 4.47666
UBQLN2 ubiquilin 2 4.4689
PNKP polynucleotide kinase 3'-phosphatase 4.38021
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.97635
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.93089
HLA-DMA major histocompatibility complex, class II, DM alpha 3.91029
DIPK1A divergent protein kinase domain 1A 3.90249
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.55961
RRAGA Ras-related GTP binding A 3.50169
MAP7 microtubule-associated protein 7 2.90309
GATA3 GATA binding protein 3 2.86461
TRAM2 translocation associated membrane protein 2 2.76814
CEMIP2 cell migration inducing hyaluronidase 2 2.72985
GATA2 GATA binding protein 2 2.69115
VGLL4 vestigial-like family member 4 2.52377
GPATCH8 G patch domain containing 8 2.36237
HOXB13 homeobox B13 2.23803
CHEK2 checkpoint kinase 2 2.20955
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 2.14034
ARID4B AT rich interactive domain 4B (RBP1-like) 2.07879
ZW10 zw10 kinetochore protein 2.07208
TPD52L2 tumor protein D52-like 2 2.02186

decreased expression

Symbol Name Standardized Value
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.6973
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.46779
ITFG1 integrin alpha FG-GAP repeat containing 1 -5.40555
CDC20 cell division cycle 20 -4.96624
VAT1 vesicle amine transport 1 -4.55716
MRPS2 mitochondrial ribosomal protein S2 -4.44
DUSP6 dual specificity phosphatase 6 -4.1004
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -4.02434
CCNB2 cyclin B2 -3.80955
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -3.61684
NRIP1 nuclear receptor interacting protein 1 -2.90452
CTNND1 catenin (cadherin-associated protein), delta 1 -2.75969
HYOU1 hypoxia up-regulated 1 -2.41731