| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | tegafur 2.6 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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74 genes differentially expressed following the CRCGN009_HEPG2_24H:H22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GSTZ1 | glutathione S-transferase zeta 1 | 5.75428 |
| ATP11B | ATPase, class VI, type 11B | 5.52242 |
| ST3GAL5 | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | 5.38683 |
| INTS3 | integrator complex subunit 3 | 5.30629 |
| PRR15L | proline rich 15-like | 4.6639 |
| MCOLN1 | mucolipin 1 | 4.29357 |
| EPN2 | epsin 2 | 4.01653 |
| SQOR | sulfide quinone oxidoreductase | 3.6925 |
| CHMP6 | charged multivesicular body protein 6 | 3.68686 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 3.64278 |
| MAP7 | microtubule-associated protein 7 | 3.61785 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 3.51574 |
| MEST | mesoderm specific transcript | 3.5013 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 3.47155 |
| PACSIN3 | protein kinase C and casein kinase substrate in neurons 3 | 3.3033 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | 3.22542 |
| ADO | 2-aminoethanethiol (cysteamine) dioxygenase | 3.04852 |
| LPAR2 | lysophosphatidic acid receptor 2 | 3.01619 |
| CCNF | cyclin F | 3.01084 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 2.88706 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 2.62957 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | 2.59004 |
| CHN1 | chimerin 1 | 2.42046 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 2.35035 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 2.31463 |
| PSMC3 | proteasome (prosome, macropain) 26S subunit, ATPase, 3 | 2.26228 |
| PMM2 | phosphomannomutase 2 | 2.19379 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | 2.0917 |
| ARF5 | ADP-ribosylation factor 5 | 2.07139 |
| GRAMD1C | GRAM domain containing 1C | 2.05521 |
| NOC2L | nucleolar complex associated 2 homolog (S. cerevisiae) | 2.05419 |
| CNGA1 | cyclic nucleotide gated channel alpha 1 | 2.05099 |
| EPB41L4B | erythrocyte membrane protein band 4.1 like 4B | 2.03791 |
| DIPK1A | divergent protein kinase domain 1A | 2.00983 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PCNA | proliferating cell nuclear antigen | -8.41579 |
| TLR4 | toll-like receptor 4 | -8.30092 |
| CCNB2 | cyclin B2 | -6.87953 |
| DNM1L | dynamin 1-like | -5.81535 |
| CCNB1 | cyclin B1 | -5.62301 |
| C2CD5 | C2 calcium-dependent domain containing 5 | -5.29275 |
| HSPB1 | heat shock 27kDa protein 1 | -5.27551 |
| TLCD3A | TLC domain containing 3A | -5.19135 |
| LDHD | lactate dehydrogenase D | -4.89638 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -4.70617 |
| CCDC86 | coiled-coil domain containing 86 | -4.50162 |
| CSK | c-src tyrosine kinase | -4.4503 |
| FASTKD5 | FAST kinase domains 5 | -4.15485 |
| NUP85 | nucleoporin 85kDa | -4.09113 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -3.93975 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | -3.44328 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | -3.23603 |
| RNASE6 | ribonuclease, RNase A family, k6 | -3.12321 |
| SQSTM1 | sequestosome 1 | -3.11909 |
| HEATR1 | HEAT repeat containing 1 | -3.05167 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -3.00469 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -2.7337 |
| GNAS | GNAS complex locus | -2.68062 |
| DERA | deoxyribose-phosphate aldolase (putative) | -2.48555 |
| EDEM1 | ER degradation enhancer, mannosidase alpha-like 1 | -2.44776 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -2.41335 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -2.35144 |
| YARS2 | tyrosyl-tRNA synthetase 2, mitochondrial | -2.30362 |
| HYOU1 | hypoxia up-regulated 1 | -2.1723 |
| SLC9A3R1 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 | -2.16873 |
| AOAH | acyloxyacyl hydrolase (neutrophil) | -2.16486 |
| MRPS7 | mitochondrial ribosomal protein S7 | -2.14979 |
| ATP1B2 | ATPase, Na+/K+ transporting, beta 2 polypeptide | -2.13168 |
| GRB2 | growth factor receptor-bound protein 2 | -2.11146 |
| GABRA6 | gamma-aminobutyric acid (GABA) A receptor, alpha 6 | -2.10911 |
| DDX47 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 | -2.09607 |
| STAMBP | STAM binding protein | -2.07901 |
| LONRF3 | LON peptidase N-terminal domain and ring finger 3 | -2.05585 |
| SV2C | synaptic vesicle glycoprotein 2C | -2.02849 |
| LOC124907782 | dual specificity protein phosphatase 22 | -2.00755 |
