| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | disodium 4-amino-3-((e)-{4'-[(e)-(2,4-diaminophenyl)diazenyl][1,1'-biphenyl]-4-yl}diazenyl)-5-hydroxy-6-[(e)-phenyldiazenyl]-2,7-naphthalenedisulfonate 20.47 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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59 genes differentially expressed following the CRCGN009_HEPG2_24H:I01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 6.70876 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 4.82056 |
| MAP7 | microtubule-associated protein 7 | 4.70638 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 3.88713 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 3.86634 |
| GPER1 | G protein-coupled estrogen receptor 1 | 3.85225 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 3.83649 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 3.78628 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | 3.76249 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 3.67287 |
| NOTCH1 | notch 1 | 3.66875 |
| PPARG | peroxisome proliferator-activated receptor gamma | 3.53003 |
| CHN1 | chimerin 1 | 3.33776 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | 3.32098 |
| SFTPB | surfactant protein B | 3.24566 |
| PEX11A | peroxisomal biogenesis factor 11 alpha | 3.12433 |
| MYLK | myosin light chain kinase | 3.09608 |
| NOSIP | nitric oxide synthase interacting protein | 3.01167 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 2.76312 |
| HSPA1A | heat shock 70kDa protein 1A | 2.6809 |
| CXCR4 | chemokine (C-X-C motif) receptor 4 | 2.61209 |
| WDR7 | WD repeat domain 7 | 2.48852 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 2.36214 |
| SLC27A3 | solute carrier family 27 (fatty acid transporter), member 3 | 2.27855 |
| MCM3 | minichromosome maintenance complex component 3 | 2.21848 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 2.20572 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 2.18136 |
| CBR3 | carbonyl reductase 3 | 2.17973 |
| SNRPA | small nuclear ribonucleoprotein polypeptide A | 2.13737 |
| PTK2 | protein tyrosine kinase 2 | 2.0922 |
| ZNF589 | zinc finger protein 589 | 2.08899 |
| MBNL2 | muscleblind-like splicing regulator 2 | 2.06098 |
| JADE2 | jade family PHD finger 2 | 2.045 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -6.53853 |
| LDHD | lactate dehydrogenase D | -5.98141 |
| CCNB2 | cyclin B2 | -4.54568 |
| SLC35F2 | solute carrier family 35, member F2 | -4.48281 |
| PLK1 | polo-like kinase 1 | -4.36837 |
| C2CD5 | C2 calcium-dependent domain containing 5 | -4.03781 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -3.89556 |
| GTPBP8 | GTP-binding protein 8 (putative) | -3.41393 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | -3.22038 |
| PCNA | proliferating cell nuclear antigen | -3.13813 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -3.09646 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -3.08201 |
| ADI1 | acireductone dioxygenase 1 | -2.98434 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -2.79309 |
| NRIP1 | nuclear receptor interacting protein 1 | -2.56893 |
| GNAS | GNAS complex locus | -2.42099 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | -2.29126 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -2.27138 |
| MAPK13 | mitogen-activated protein kinase 13 | -2.23131 |
| CHMP4B | charged multivesicular body protein 4B | -2.1729 |
| IL4R | interleukin 4 receptor | -2.15581 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | -2.13641 |
| ZNF586 | zinc finger protein 586 | -2.11366 |
| RGS2 | regulator of G-protein signaling 2 | -2.09721 |
| CSK | c-src tyrosine kinase | -2.07925 |
| CMC2 | C-x(9)-C motif containing 2 | -2.01794 |
