CRCGN009_HEPG2_24H:I02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description disodium 4-amino-3-((e)-{4'-[(e)-(2,4-diaminophenyl)diazenyl][1,1'-biphenyl]-4-yl}diazenyl)-5-hydroxy-6-[(e)-phenyldiazenyl]-2,7-naphthalenedisulfonate 10.23 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

59 genes differentially expressed following the CRCGN009_HEPG2_24H:I02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RPP38 ribonuclease P/MRP 38kDa subunit 7.27741
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.40327
SYNE2 spectrin repeat containing, nuclear envelope 2 3.86647
NOTCH1 notch 1 3.69224
HOXA10 homeobox A10 3.28175
PRKCH protein kinase C, eta 3.27685
PPARG peroxisome proliferator-activated receptor gamma 3.24558
CIAO3 cytosolic iron-sulfur assembly component 3 3.10553
CYCS cytochrome c, somatic 3.00791
KDM5A lysine (K)-specific demethylase 5A 2.69741
GATA2 GATA binding protein 2 2.62172
MAP7 microtubule-associated protein 7 2.58668
ADAM10 ADAM metallopeptidase domain 10 2.56896
CXCL2 chemokine (C-X-C motif) ligand 2 2.5519
BZW2 basic leucine zipper and W2 domains 2 2.49712
GSTZ1 glutathione S-transferase zeta 1 2.35705
IGFBP3 insulin-like growth factor binding protein 3 2.33198
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.32152
HDGFL3 HDGF like 3 2.29629
NRBP1 nuclear receptor binding protein 1 2.24637
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.24213
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.05741
RRAGA Ras-related GTP binding A 2.01839

decreased expression

Symbol Name Standardized Value
DHRS7 dehydrogenase/reductase (SDR family) member 7 -10.0
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -5.75476
ZNF586 zinc finger protein 586 -5.55486
CCNB1 cyclin B1 -4.69645
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.42714
CSK c-src tyrosine kinase -4.26798
MRPS2 mitochondrial ribosomal protein S2 -4.14611
MRPS16 mitochondrial ribosomal protein S16 -4.04447
TLCD3A TLC domain containing 3A -3.5118
SLC35F2 solute carrier family 35, member F2 -3.20487
CDC20 cell division cycle 20 -3.0199
PCNA proliferating cell nuclear antigen -2.99101
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.96212
LDHD lactate dehydrogenase D -2.86922
NGRN neugrin, neurite outgrowth associated -2.83917
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.81697
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.70985
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.68422
NRIP1 nuclear receptor interacting protein 1 -2.66788
TLR4 toll-like receptor 4 -2.60119
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -2.59309
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.57937
KDM3A lysine (K)-specific demethylase 3A -2.56499
ADI1 acireductone dioxygenase 1 -2.51999
PCDHA9 protocadherin alpha 9 -2.33132
GNAS GNAS complex locus -2.32589
NISCH nischarin -2.28235
BIRC2 baculoviral IAP repeat containing 2 -2.25685
MAPK13 mitogen-activated protein kinase 13 -2.25501
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 -2.16114
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled -2.15136
FASTKD5 FAST kinase domains 5 -2.13413
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.11808
NEUROD1 neuronal differentiation 1 -2.10042
PAEP progestagen-associated endometrial protein -2.09409
PRDM8 PR domain containing 8 -2.05343