CRCGN009_HEPG2_24H:I03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description disodium 4-amino-3-((e)-{4'-[(e)-(2,4-diaminophenyl)diazenyl][1,1'-biphenyl]-4-yl}diazenyl)-5-hydroxy-6-[(e)-phenyldiazenyl]-2,7-naphthalenedisulfonate 5.12 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

68 genes differentially expressed following the CRCGN009_HEPG2_24H:I03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 6.11644
HLA-DMA major histocompatibility complex, class II, DM alpha 5.30161
CYCS cytochrome c, somatic 5.17025
CXCL2 chemokine (C-X-C motif) ligand 2 5.13654
E2F2 E2F transcription factor 2 4.69931
STX1A syntaxin 1A (brain) 4.69119
GPER1 G protein-coupled estrogen receptor 1 4.54464
MOK MOK protein kinase 4.45322
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.37156
ABHD4 abhydrolase domain containing 4 4.10612
CNPY3 canopy FGF signaling regulator 3 3.9133
GATA3 GATA binding protein 3 3.42044
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 3.2916
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 3.04141
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 2.89952
HOXA10 homeobox A10 2.77723
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.76415
LCN2 lipocalin 2 2.55744
PEX11A peroxisomal biogenesis factor 11 alpha 2.36987
EVL Enah/Vasp-like 2.36146
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.33533
GSTZ1 glutathione S-transferase zeta 1 2.18591
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.13185
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q 2.08968
GATA2 GATA binding protein 2 2.05751
CHMP6 charged multivesicular body protein 6 2.05132
EPN2 epsin 2 2.01254

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -7.54002
PCNA proliferating cell nuclear antigen -7.06351
LAP3 leucine aminopeptidase 3 -5.16987
CDC20 cell division cycle 20 -4.91351
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.84294
NT5DC2 5'-nucleotidase domain containing 2 -4.82858
ADI1 acireductone dioxygenase 1 -4.74053
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.676
ZNF586 zinc finger protein 586 -4.19985
UBE3C ubiquitin protein ligase E3C -4.10298
TLR4 toll-like receptor 4 -4.02727
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -3.67799
PEG10 paternally expressed 10 -3.60004
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.39586
GNAS GNAS complex locus -3.30341
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -3.29389
FBXL12 F-box and leucine-rich repeat protein 12 -3.28828
SLC35F2 solute carrier family 35, member F2 -3.21001
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.77502
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.74757
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.71146
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.63282
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.6161
PDHX pyruvate dehydrogenase complex, component X -2.58002
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.57521
OXA1L oxidase (cytochrome c) assembly 1-like -2.52225
EGF epidermal growth factor -2.51103
PLK1 polo-like kinase 1 -2.44847
PECR peroxisomal trans-2-enoyl-CoA reductase -2.39648
FBXO3 F-box protein 3 -2.3653
TES testin LIM domain protein -2.22992
SLBP stem-loop binding protein -2.22781
CCNB2 cyclin B2 -2.21105
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.19608
CHMP4B charged multivesicular body protein 4B -2.17863
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.15125
CHIC2 cysteine-rich hydrophobic domain 2 -2.10026
TSEN34 TSEN34 tRNA splicing endonuclease subunit -2.07076
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.05732
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.03097
FHL2 four and a half LIM domains 2 -2.02584