CRCGN009_HEPG2_24H:I04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description disodium 4-amino-3-((e)-{4'-[(e)-(2,4-diaminophenyl)diazenyl][1,1'-biphenyl]-4-yl}diazenyl)-5-hydroxy-6-[(e)-phenyldiazenyl]-2,7-naphthalenedisulfonate 2.56 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

56 genes differentially expressed following the CRCGN009_HEPG2_24H:I04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 7.42673
UBQLN2 ubiquilin 2 6.95134
NOTCH1 notch 1 5.17172
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.63299
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.51524
ADGRE5 adhesion G protein-coupled receptor E5 4.42055
LCN2 lipocalin 2 4.39262
CARMIL1 capping protein regulator and myosin 1 linker 1 4.35161
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.20941
PLS1 plastin 1 4.1021
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.90303
CHN1 chimerin 1 2.87617
KLHL9 kelch-like family member 9 2.86784
EPHA3 EPH receptor A3 2.86283
MAMLD1 mastermind-like domain containing 1 2.85054
MYLK myosin light chain kinase 2.84135
NENF neudesin neurotrophic factor 2.79208
STIMATE STIM activating enhancer 2.68533
HLA-DRA major histocompatibility complex, class II, DR alpha 2.65051
GPER1 G protein-coupled estrogen receptor 1 2.54008
CCL2 chemokine (C-C motif) ligand 2 2.53893
ATP11B ATPase, class VI, type 11B 2.39764
GARRE1 granule associated Rac and RHOG effector 1 2.39146
ANO1 anoctamin 1, calcium activated chloride channel 2.35453
RAB11FIP1 RAB11 family interacting protein 1 (class I) 2.1673
TBP TATA box binding protein 2.15983
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.06789

decreased expression

Symbol Name Standardized Value
TLR4 toll-like receptor 4 -5.7067
TSEN2 TSEN2 tRNA splicing endonuclease subunit -5.46432
PCNA proliferating cell nuclear antigen -5.22877
CDC20 cell division cycle 20 -4.96536
TLCD3A TLC domain containing 3A -4.86867
GOLT1B golgi transport 1B -4.82955
ZDHHC6 zinc finger, DHHC-type containing 6 -4.41183
ZMIZ1 zinc finger, MIZ-type containing 1 -4.37868
LAP3 leucine aminopeptidase 3 -4.27454
TM9SF3 transmembrane 9 superfamily member 3 -4.15983
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.0458
ZNF586 zinc finger protein 586 -4.01296
CSK c-src tyrosine kinase -3.33574
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.28751
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.13394
ITGB1BP1 integrin beta 1 binding protein 1 -3.09841
TM9SF2 transmembrane 9 superfamily member 2 -3.09456
NGRN neugrin, neurite outgrowth associated -2.90925
OXA1L oxidase (cytochrome c) assembly 1-like -2.83428
FBXL12 F-box and leucine-rich repeat protein 12 -2.75677
CCNB1 cyclin B1 -2.55987
TBC1D19 TBC1 domain family, member 19 -2.55096
EIF5 eukaryotic translation initiation factor 5 -2.451
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.15364
RNF167 ring finger protein 167 -2.14981
LDHD lactate dehydrogenase D -2.12004
PECR peroxisomal trans-2-enoyl-CoA reductase -2.10206
GNAS GNAS complex locus -2.08974
WASHC4 WASH complex subunit 4 -2.02246