CRCGN009_HEPG2_24H:I06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description disodium 4-amino-3-((e)-{4'-[(e)-(2,4-diaminophenyl)diazenyl][1,1'-biphenyl]-4-yl}diazenyl)-5-hydroxy-6-[(e)-phenyldiazenyl]-2,7-naphthalenedisulfonate 0.64 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

113 genes differentially expressed following the CRCGN009_HEPG2_24H:I06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
BACE2 beta-site APP-cleaving enzyme 2 5.74306
MYLK myosin light chain kinase 5.01072
UBQLN2 ubiquilin 2 4.9189
ADGRE5 adhesion G protein-coupled receptor E5 4.90011
MAMLD1 mastermind-like domain containing 1 4.75803
SNAP25 synaptosomal-associated protein, 25kDa 4.74989
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.63657
LPAR2 lysophosphatidic acid receptor 2 4.61767
HLA-DMA major histocompatibility complex, class II, DM alpha 4.55737
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.54887
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 4.45894
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.39863
CBR3 carbonyl reductase 3 4.26069
MINDY1 MINDY lysine 48 deubiquitinase 1 4.21173
RAB11FIP1 RAB11 family interacting protein 1 (class I) 4.15364
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.11717
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.93167
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.48773
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.46684
PEX11A peroxisomal biogenesis factor 11 alpha 3.25515
MAP7 microtubule-associated protein 7 3.22767
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.09582
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.82601
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.66036
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.63799
JADE2 jade family PHD finger 2 2.59701
PLSCR3 phospholipid scramblase 3 2.58817
TBX21 T-box 21 2.55765
AGO1 argonaute RISC catalytic component 1 2.50566
GPER1 G protein-coupled estrogen receptor 1 2.48688
MXD1 MAX dimerization protein 1 2.45749
RAB21 RAB21, member RAS oncogene family 2.44505
CEMIP2 cell migration inducing hyaluronidase 2 2.43175
SMAP1 small ArfGAP 1 2.38888
MCM3 minichromosome maintenance complex component 3 2.37675
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 2.36871
CX3CR1 chemokine (C-X3-C motif) receptor 1 2.3682
TTC28 tetratricopeptide repeat domain 28 2.3361
MACIR macrophage immunometabolism regulator 2.31764
SMIM40 small integral membrane protein 40 2.30848
GRAMD1B GRAM domain containing 1B 2.26589
TBP TATA box binding protein 2.25508
YES1 YES proto-oncogene 1, Src family tyrosine kinase 2.25063
INSL4 insulin-like 4 (placenta) 2.2325
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 2.20762
CTSL cathepsin L 2.19123
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 2.17344
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 2.13151
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.12904
ZNF428 zinc finger protein 428 2.12335
BAHCC1 BAH domain and coiled-coil containing 1 2.12058
CHEK2 checkpoint kinase 2 2.1062
REEP4 receptor accessory protein 4 2.09364
SOX3 SRY (sex determining region Y)-box 3 2.07224
CCNF cyclin F 2.07089
BLTP3B bridge-like lipid transfer protein family member 3B 2.06876
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.06451
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.04714
BUB3 BUB3 mitotic checkpoint protein 2.03372
AGR2 anterior gradient 2 2.03285
ZNF222 zinc finger protein 222 2.03245
TSPAN6 tetraspanin 6 2.02095

decreased expression

Symbol Name Standardized Value
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -9.28952
PCNA proliferating cell nuclear antigen -8.96717
CD320 CD320 molecule -5.16365
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.11739
SMNDC1 survival motor neuron domain containing 1 -5.00939
GOLT1B golgi transport 1B -4.90568
FBXL12 F-box and leucine-rich repeat protein 12 -4.88837
NUP85 nucleoporin 85kDa -4.8701
RPIA ribose 5-phosphate isomerase A -4.70267
PECR peroxisomal trans-2-enoyl-CoA reductase -4.64287
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.60428
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -4.51979
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.50557
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.42427
CCNB2 cyclin B2 -3.93559
ZMIZ1 zinc finger, MIZ-type containing 1 -3.87974
NGRN neugrin, neurite outgrowth associated -3.80401
CHMP4B charged multivesicular body protein 4B -3.59351
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.51101
LYPLA1 lysophospholipase I -3.47583
MRPS7 mitochondrial ribosomal protein S7 -3.44037
MRPL58 mitochondrial ribosomal protein L58 -3.35607
WASHC4 WASH complex subunit 4 -3.22333
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.89659
GNAS GNAS complex locus -2.788
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.73998
TLR4 toll-like receptor 4 -2.59713
SESN1 sestrin 1 -2.5713
STX4 syntaxin 4 -2.53878
GSTP1 glutathione S-transferase pi 1 -2.40107
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.39995
ATP5PD ATP synthase peripheral stalk subunit d -2.32712
CHIC2 cysteine-rich hydrophobic domain 2 -2.29602
KCTD2 potassium channel tetramerization domain containing 2 -2.25509
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -2.24178
CSK c-src tyrosine kinase -2.212
BANK1 B-cell scaffold protein with ankyrin repeats 1 -2.1865
HPCAL1 hippocalcin-like 1 -2.16355
UCKL1 uridine-cytidine kinase 1-like 1 -2.13629
FILIP1L filamin A interacting protein 1-like -2.1344
GINS4 GINS complex subunit 4 (Sld5 homolog) -2.13183
CCNDBP1 cyclin D-type binding-protein 1 -2.12467
ACADL acyl-CoA dehydrogenase, long chain -2.11353
RMDN3 regulator of microtubule dynamics 3 -2.10394
ITGB1BP1 integrin beta 1 binding protein 1 -2.0845
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa -2.06426
ZNF365 zinc finger protein 365 -2.04796
AUP1 ancient ubiquitous protein 1 -2.02959
HAGH hydroxyacylglutathione hydrolase -2.02794
BRMS1L breast cancer metastasis-suppressor 1-like -2.00121
LRRC8E leucine rich repeat containing 8 family, member E -2.00079