CRCGN009_HEPG2_24H:I07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (3r,4r,5r,13ar,13br)-4,5-dihydroxy-3,4,5-trimethyl-4,5,8,10,12,13,13a,13b-octahydro-2h-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3h)-dione 21.24 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

56 genes differentially expressed following the CRCGN009_HEPG2_24H:I07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 8.75812
LAGE3 L antigen family, member 3 4.7789
MOK MOK protein kinase 4.40755
RPP38 ribonuclease P/MRP 38kDa subunit 4.28215
MAP7 microtubule-associated protein 7 3.90979
STIMATE STIM activating enhancer 3.84481
MCM3 minichromosome maintenance complex component 3 3.27713
CCL2 chemokine (C-C motif) ligand 2 3.17696
GSTZ1 glutathione S-transferase zeta 1 2.97023
KIFBP kinesin family binding protein 2.80276
HLA-DRA major histocompatibility complex, class II, DR alpha 2.79032
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.61069
RAB11FIP1 RAB11 family interacting protein 1 (class I) 2.59721
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 2.58963
LCN2 lipocalin 2 2.57422
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.39983
CNPY3 canopy FGF signaling regulator 3 2.32816
ZNF589 zinc finger protein 589 2.26699
GPATCH8 G patch domain containing 8 2.24798
ADAM10 ADAM metallopeptidase domain 10 2.20373
DIPK1A divergent protein kinase domain 1A 2.16126
NOTCH1 notch 1 2.08607
HEBP1 heme binding protein 1 2.01008

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -8.34578
LDHD lactate dehydrogenase D -8.32967
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -5.50654
LAP3 leucine aminopeptidase 3 -4.65855
KDM3A lysine (K)-specific demethylase 3A -4.50983
PLK1 polo-like kinase 1 -4.49711
TLR4 toll-like receptor 4 -4.33527
GOLT1B golgi transport 1B -3.93457
GNAS GNAS complex locus -3.366
RHEB Ras homolog enriched in brain -3.32158
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.32097
ZNF586 zinc finger protein 586 -3.10246
CD58 CD58 molecule -2.90245
SLC4A2 solute carrier family 4 (anion exchanger), member 2 -2.82817
CSK c-src tyrosine kinase -2.8074
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.79638
MAPK13 mitogen-activated protein kinase 13 -2.66965
EGF epidermal growth factor -2.61246
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.47612
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.45853
UCKL1 uridine-cytidine kinase 1-like 1 -2.36043
ND5 NADH dehydrogenase subunit 5 -2.28578
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.27568
OXA1L oxidase (cytochrome c) assembly 1-like -2.26229
FGF9 fibroblast growth factor 9 -2.24857
ENY2 enhancer of yellow 2 homolog (Drosophila) -2.20413
ACTR3B ARP3 actin-related protein 3 homolog B (yeast) -2.18144
ZNF212 zinc finger protein 212 -2.16908
LIMS1 LIM and senescent cell antigen-like domains 1 -2.14795
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.12275
FAM3C family with sequence similarity 3, member C -2.11116
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.10286
NRGN neurogranin (protein kinase C substrate, RC3) -2.03864