CRCGN009_HEPG2_24H:I08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (3r,4r,5r,13ar,13br)-4,5-dihydroxy-3,4,5-trimethyl-4,5,8,10,12,13,13a,13b-octahydro-2h-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3h)-dione 10.62 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

80 genes differentially expressed following the CRCGN009_HEPG2_24H:I08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic 7.24507
MNAT1 MNAT CDK-activating kinase assembly factor 1 4.78083
ANO1 anoctamin 1, calcium activated chloride channel 4.77134
CHMP6 charged multivesicular body protein 6 4.73571
AMDHD2 amidohydrolase domain containing 2 4.59104
LCN2 lipocalin 2 4.17823
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.14665
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.12662
STXBP2 syntaxin binding protein 2 3.42524
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.39293
HOXA10 homeobox A10 3.36569
PRR15L proline rich 15-like 3.07453
FZD7 frizzled class receptor 7 2.99643
HSPA1A heat shock 70kDa protein 1A 2.96888
GPER1 G protein-coupled estrogen receptor 1 2.92513
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 2.81431
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.76147
NUP133 nucleoporin 133kDa 2.65442
GATA2 GATA binding protein 2 2.58727
PLSCR3 phospholipid scramblase 3 2.55042
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.50003
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.42046
RHOA ras homolog family member A 2.33061
KIF20A kinesin family member 20A 2.29055
SERTAD2 SERTA domain containing 2 2.24949
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.23299
SIX1 SIX homeobox 1 2.21533
EPHA3 EPH receptor A3 2.18636
LPAR2 lysophosphatidic acid receptor 2 2.15023
COPS7A COP9 signalosome subunit 7A 2.13027
CHN1 chimerin 1 2.09713
ATP7B ATPase, Cu++ transporting, beta polypeptide 2.08101
TCF12 transcription factor 12 2.01486
BAG2 BCL2-associated athanogene 2 2.01191
LRRC59 leucine rich repeat containing 59 2.00073

decreased expression

Symbol Name Standardized Value
ZMIZ1 zinc finger, MIZ-type containing 1 -8.03494
OXA1L oxidase (cytochrome c) assembly 1-like -6.77677
LDHD lactate dehydrogenase D -5.06687
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.74504
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.71317
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.70829
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -4.70382
GTPBP8 GTP-binding protein 8 (putative) -4.65514
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.52009
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.34628
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.31617
NISCH nischarin -4.11376
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.57943
PRPF4 pre-mRNA processing factor 4 -3.37649
SCAND1 SCAN domain containing 1 -3.34143
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -3.28038
ACAA1 acetyl-CoA acyltransferase 1 -3.25878
EIF5 eukaryotic translation initiation factor 5 -3.16922
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -3.1097
ATF6 activating transcription factor 6 -2.99611
NRIP1 nuclear receptor interacting protein 1 -2.64224
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 -2.59414
EGF epidermal growth factor -2.52418
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa -2.5086
DCK deoxycytidine kinase -2.49923
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 -2.38834
KIAA0513 KIAA0513 -2.32713
CCDC177 coiled-coil domain containing 177 -2.30309
ABHD18 abhydrolase domain containing 18 -2.29807
SNCB synuclein, beta -2.23439
GET1 guided entry of tail-anchored proteins factor 1 -2.22348
PRR11 proline rich 11 -2.20398
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.20003
RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1 -2.19725
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.15123
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 -2.11871
TBX2 T-box 2 -2.10795
SNAP29 synaptosomal-associated protein, 29kDa -2.10138
DRC4 dynein regulatory complex subunit 4 -2.07483
FBXO2 F-box protein 2 -2.06652
IQSEC2 IQ motif and Sec7 domain 2 -2.04329
DOC2A double C2-like domains, alpha -2.03115
GRB7 growth factor receptor-bound protein 7 -2.02786
EPM2AIP1 EPM2A (laforin) interacting protein 1 -2.01959
AHDC1 AT hook, DNA binding motif, containing 1 -2.00719