| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | (3r,4r,5r,13ar,13br)-4,5-dihydroxy-3,4,5-trimethyl-4,5,8,10,12,13,13a,13b-octahydro-2h-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3h)-dione 5.31 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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70 genes differentially expressed following the CRCGN009_HEPG2_24H:I09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 9.06084 |
| HEBP1 | heme binding protein 1 | 6.33458 |
| UBQLN2 | ubiquilin 2 | 5.54623 |
| C2CD2 | C2 calcium-dependent domain containing 2 | 5.36165 |
| TAC4 | tachykinin 4 (hemokinin) | 5.22527 |
| EVL | Enah/Vasp-like | 5.01585 |
| ADRB2 | adrenoceptor beta 2, surface | 4.99046 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 4.98046 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 4.72563 |
| MYLK | myosin light chain kinase | 4.61494 |
| E2F2 | E2F transcription factor 2 | 4.28739 |
| SH3D19 | SH3 domain containing 19 | 3.24941 |
| EPN2 | epsin 2 | 3.15486 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 3.15153 |
| WDR7 | WD repeat domain 7 | 3.08254 |
| CCNF | cyclin F | 2.95225 |
| NFATC4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | 2.84748 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 2.60653 |
| GATA2 | GATA binding protein 2 | 2.60217 |
| SLC27A3 | solute carrier family 27 (fatty acid transporter), member 3 | 2.54598 |
| DNMT3A | DNA (cytosine-5-)-methyltransferase 3 alpha | 2.5308 |
| RXYLT1 | ribitol xylosyltransferase 1 | 2.50165 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 2.49826 |
| HYOU1 | hypoxia up-regulated 1 | 2.45119 |
| MEST | mesoderm specific transcript | 2.28435 |
| JADE2 | jade family PHD finger 2 | 2.22902 |
| TXNL4B | thioredoxin-like 4B | 2.21771 |
| DPY19L1 | dpy-19-like 1 (C. elegans) | 2.16665 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 2.143 |
| RAI1 | retinoic acid induced 1 | 2.08476 |
| PMM2 | phosphomannomutase 2 | 2.07368 |
| CDH18 | cadherin 18, type 2 | 2.03066 |
| RAB3A | RAB3A, member RAS oncogene family | 2.03048 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZNF586 | zinc finger protein 586 | -9.70741 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -7.23195 |
| MAPK13 | mitogen-activated protein kinase 13 | -5.96054 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -4.91327 |
| STK25 | serine/threonine kinase 25 | -4.84053 |
| TLR4 | toll-like receptor 4 | -4.73732 |
| ADI1 | acireductone dioxygenase 1 | -4.49804 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -4.46586 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -4.38759 |
| DSG2 | desmoglein 2 | -4.34995 |
| FAIM | Fas apoptotic inhibitory molecule | -4.21856 |
| DNTTIP2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | -4.18161 |
| CSK | c-src tyrosine kinase | -3.38988 |
| CCNB2 | cyclin B2 | -3.21405 |
| TCTN1 | tectonic family member 1 | -3.19056 |
| TM9SF2 | transmembrane 9 superfamily member 2 | -3.07164 |
| PSMB10 | proteasome (prosome, macropain) subunit, beta type, 10 | -2.95749 |
| ZNF587 | zinc finger protein 587 | -2.88689 |
| ZNF587B | zinc finger protein 587B | -2.79282 |
| CDC25B | cell division cycle 25B | -2.72502 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.64132 |
| PLA2G15 | phospholipase A2, group XV | -2.51378 |
| HEATR1 | HEAT repeat containing 1 | -2.45726 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -2.43836 |
| ZNF134 | zinc finger protein 134 | -2.41349 |
| ZW10 | zw10 kinetochore protein | -2.36165 |
| GATC | glutamyl-tRNA(Gln) amidotransferase, subunit C | -2.28376 |
| PEG10 | paternally expressed 10 | -2.28235 |
| STK38 | serine/threonine kinase 38 | -2.16866 |
| DERA | deoxyribose-phosphate aldolase (putative) | -2.15552 |
| SSBP2 | single-stranded DNA binding protein 2 | -2.11924 |
| TSKU | tsukushi, small leucine rich proteoglycan | -2.11896 |
| ZNF91 | zinc finger protein 91 | -2.10236 |
| IFRD2 | interferon-related developmental regulator 2 | -2.06178 |
| PLBD1 | phospholipase B domain containing 1 | -2.05396 |
| TXLNA | taxilin alpha | -2.0089 |
| CRISPLD2 | cysteine-rich secretory protein LCCL domain containing 2 | -2.00179 |
