| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | (3r,4r,5r,13ar,13br)-4,5-dihydroxy-3,4,5-trimethyl-4,5,8,10,12,13,13a,13b-octahydro-2h-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3h)-dione 2.65 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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58 genes differentially expressed following the CRCGN009_HEPG2_24H:I10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MAP7 | microtubule-associated protein 7 | 7.60736 |
| PPARG | peroxisome proliferator-activated receptor gamma | 7.14953 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 5.91721 |
| RPP38 | ribonuclease P/MRP 38kDa subunit | 5.87501 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 5.56472 |
| RPL39L | ribosomal protein L39-like | 4.05321 |
| UBQLN2 | ubiquilin 2 | 4.02039 |
| CYCS | cytochrome c, somatic | 3.48704 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 3.4642 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 3.30069 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 3.22568 |
| AGL | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | 3.21193 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 3.18044 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | 3.15372 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 3.10754 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 2.93555 |
| C2CD2 | C2 calcium-dependent domain containing 2 | 2.78415 |
| STIMATE | STIM activating enhancer | 2.68955 |
| ZFP36 | ZFP36 ring finger protein | 2.6617 |
| GATA3 | GATA binding protein 3 | 2.56863 |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | 2.51001 |
| ZNF589 | zinc finger protein 589 | 2.43468 |
| PRR15L | proline rich 15-like | 2.34769 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 2.34098 |
| H2BC12 | H2B clustered histone 12 | 2.25185 |
| SFTPB | surfactant protein B | 2.17584 |
| GRB10 | growth factor receptor-bound protein 10 | 2.14671 |
| FZD7 | frizzled class receptor 7 | 2.14507 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LDHD | lactate dehydrogenase D | -6.15637 |
| PCNA | proliferating cell nuclear antigen | -5.43421 |
| MAPK13 | mitogen-activated protein kinase 13 | -4.60728 |
| TRIB3 | tribbles pseudokinase 3 | -4.00758 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -3.82305 |
| ADI1 | acireductone dioxygenase 1 | -3.64955 |
| AURKB | aurora kinase B | -3.57692 |
| CDC20 | cell division cycle 20 | -3.48575 |
| FASTKD5 | FAST kinase domains 5 | -3.46673 |
| TUBB6 | tubulin, beta 6 class V | -3.45223 |
| PRPF4 | pre-mRNA processing factor 4 | -3.42252 |
| DERA | deoxyribose-phosphate aldolase (putative) | -3.35085 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -3.2409 |
| FGFR4 | fibroblast growth factor receptor 4 | -3.20169 |
| CD320 | CD320 molecule | -3.13023 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -3.07203 |
| KDM3A | lysine (K)-specific demethylase 3A | -3.02343 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -3.01707 |
| ZW10 | zw10 kinetochore protein | -2.67889 |
| UBE3C | ubiquitin protein ligase E3C | -2.66084 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -2.59691 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -2.36995 |
| ZNF586 | zinc finger protein 586 | -2.34648 |
| TIMELESS | timeless circadian clock | -2.28124 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -2.19826 |
| CCNB2 | cyclin B2 | -2.14838 |
| NGRN | neugrin, neurite outgrowth associated | -2.14608 |
| FCHO1 | FCH domain only 1 | -2.12015 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -2.03901 |
| SUPV3L1 | suppressor of var1, 3-like 1 (S. cerevisiae) | -2.01266 |
